Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex [PDF]
Nature Communications, 2023 The identification and characterization of enzyme function is largely lacking behind the rapidly increasing availability of large numbers of sequences and associated high-resolution structures.
Nikos Pinotsis +9 more
doaj +5 more sources
A New Ultrasensitive Bioluminescence-Based Method for Assaying Monoacylglycerol Lipase [PDF]
International Journal of Molecular Sciences, 2021 A novel bioluminescent Monoacylglycerol lipase (MAGL) substrate 6-O-arachidonoylluciferin, a D-luciferin derivative, was synthesized, physico-chemically characterized, and used as highly sensitive substrate for MAGL in an assay developed for this purpose.
Matteo Miceli +2 more
exaly +3 more sources
Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration [PDF]
JHEP Reports, 2023 Background & Aims: Liver regeneration is a repair process in which metabolic reprogramming of parenchymal and inflammatory cells plays a major role. Monoacylglycerol lipase (MAGL) is an ubiquitous enzyme at the crossroad between lipid metabolism and ...
Manon Allaire +15 more
doaj +4 more sources
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. [PDF]
J Med Chem, 2022 Monoacylglycerol lipase (MAGL) is the enzyme responsible for the metabolism of 2-arachidonoylglycerol in the brain and the hydrolysis of peripheral monoacylglycerols.
Bononi G +19 more
europepmc +6 more sources
The biological functions of monoacylglycerol lipase (MAGL) in cancer [PDF]
Saudi Pharmaceutical JournalCancer is a metabolic disease marked by disruptions in lipid metabolism, which significantly influences tumor development. The synthesis and breakdown of lipids, governed by various enzymes, play a vital role in this process.
Faris Almutairi
doaj +2 more sources
Arachis hypogaea monoacylglycerol lipase AhMAGL3b participates in lipid metabolism [PDF]
BMC Plant BiologyBackground Monoacylglycerol lipase (MAGL) belongs to the serine hydrolase family; it catalyzes MAG to produce glycerol and free fatty acids (FFAs), which is the final step in triacylglycerol (TAG) hydrolysis.
Yihua Zhan +4 more
doaj +2 more sources
Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease. [PDF]
World J Gastroenterol, 2020 Dietary oversupply of triglycerides represent the hallmark of obesity and connected complications in the liver such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, which eventually progress to cirrhosis and hepatocellular ...
Tardelli M.
europepmc +2 more sources
Genome-wide identification and mining elite allele variation of the Monoacylglycerol lipase (MAGL) gene family in upland cotton (Gossypium hirsutum L.) [PDF]
BMC Plant BiologyBackground Monoacylglycerol lipase (MAGL) genes belong to the alpha/beta hydrolase superfamily, catalyze the terminal step of triglyceride (TAG) hydrolysis, converting monoacylglycerol (MAG) into free fatty acids and glycerol.
Zhibin Zhou +7 more
doaj +2 more sources
3D-QSAR study of benzotriazol-1-yl carboxamide scaffold as monoacylglycerol lipase inhibitors
Journal of Pharmacy and Bioallied Sciences, 2014 Purpose: The purpose of this study is to build up the 3D pharmacophore of Monoacylglycerol lipase (MAGL) inhibitor and to provide the basis to design the novel and potent MAGL inhibitors.
Obaid Afzal +4 more
doaj +2 more sources
A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase [PDF]
Angewandte Chemie - International EditionJörg Benz +2 more
exaly +2 more sources