Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex [PDF]
Nature Communications, 2023 The identification and characterization of enzyme function is largely lacking behind the rapidly increasing availability of large numbers of sequences and associated high-resolution structures.
Nikos Pinotsis +9 more
doaj +7 more sources
Monoacylglycerol Lipase Regulates Fever Response. [PDF]
PLoS ONE, 2015 Cyclooxygenase inhibitors such as ibuprofen have been used for decades to control fever through reducing the levels of the pyrogenic lipid transmitter prostaglandin E2 (PGE2).
Manuel Sanchez-Alavez +7 more
doaj +4 more sources
The biological functions of monoacylglycerol lipase (MAGL) in cancer [PDF]
Saudi Pharmaceutical JournalCancer is a metabolic disease marked by disruptions in lipid metabolism, which significantly influences tumor development. The synthesis and breakdown of lipids, governed by various enzymes, play a vital role in this process.
Faris Almutairi
doaj +2 more sources
Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration [PDF]
JHEP Reports, 2023 Background & Aims: Liver regeneration is a repair process in which metabolic reprogramming of parenchymal and inflammatory cells plays a major role. Monoacylglycerol lipase (MAGL) is an ubiquitous enzyme at the crossroad between lipid metabolism and ...
Manon Allaire +15 more
doaj +2 more sources
Monoacylglycerol lipase – a target for drug development? [PDF]
British Journal of Pharmacology, 2012 The endocannabinoid (eCB) system is involved in processes as diverse as control of appetite, perception of pain and the limitation of cancer cell growth and invasion. The enzymes responsible for eCB breakdown are attractive pharmacological targets, and fatty acid amide hydrolase inhibitors, which potentiate the levels of the eCB anandamide, are now ...
Christopher J Fowler
exaly +3 more sources
Arachis hypogaea monoacylglycerol lipase AhMAGL3b participates in lipid metabolism [PDF]
BMC Plant BiologyBackground Monoacylglycerol lipase (MAGL) belongs to the serine hydrolase family; it catalyzes MAG to produce glycerol and free fatty acids (FFAs), which is the final step in triacylglycerol (TAG) hydrolysis.
Yihua Zhan +4 more
doaj +2 more sources
Genome-wide identification and mining elite allele variation of the Monoacylglycerol lipase (MAGL) gene family in upland cotton (Gossypium hirsutum L.) [PDF]
BMC Plant BiologyBackground Monoacylglycerol lipase (MAGL) genes belong to the alpha/beta hydrolase superfamily, catalyze the terminal step of triglyceride (TAG) hydrolysis, converting monoacylglycerol (MAG) into free fatty acids and glycerol.
Zhibin Zhou +7 more
doaj +2 more sources
Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators. [PDF]
ACS Med Chem Lett, 2022 Sabnis RW.
europepmc +4 more sources
Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease
Cell Reports, 2012 Alzheimer's disease (AD) is the most common cause of dementia among older people. There are no effective medications currently available to prevent and treat AD and halt disease progression.
Rongqing Chen +7 more
doaj +5 more sources
Production of a lipase from a pseudomonad species [PDF]
, 1991 A lipase-producing micro-organism was found to be a strain of Pseudomonas aeruginosa. When it was grown batchwise in a stirred 2 dM3 fermenter in a simple defined minimal salts medium containing yeast extract and glucose, it produced lipase at a ...
Smith, Catherine J.
core +7 more sources