Results 11 to 20 of about 11,083 (203)
Monoacylglycerol Lipase Regulates Fever Response. [PDF]
PLoS ONE, 2015 Cyclooxygenase inhibitors such as ibuprofen have been used for decades to control fever through reducing the levels of the pyrogenic lipid transmitter prostaglandin E2 (PGE2).
Manuel Sanchez-Alavez +7 more
doaj +4 more sources
Assay of Monoacylglycerol Lipase Activity [PDF]
, 2016 Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). 2-AG is one of the main endogenous lipid agonists for cannabinoid receptors in the brain and elsewhere ...
Kwang-Mook Jung +3 more
core +7 more sources
Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease
Cell Reports, 2012 Alzheimer's disease (AD) is the most common cause of dementia among older people. There are no effective medications currently available to prevent and treat AD and halt disease progression.
Rongqing Chen +7 more
doaj +5 more sources
Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors [PDF]
Chemistry & Biology, 2009 National Institute on Drug Abuse [R01 DA-012447]; NIH [T32NS007444-7]; Italian Ministry of University and Research [2005032713_002]Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2 ...
邱彦 +11 more
core +4 more sources
ROG1 encodes a monoacylglycerol lipase in Saccharomyces cerevisiae [PDF]
FEBS Letters, 2015 Lipid metabolism is extensively studied in Saccharomyces cerevisiae. Here, we report that revertant of glycogen synthase kinase mutation-1 (Rog1p) possesses monoacylglycerol (MAG) lipase activity in S. cerevisiae.
Vasanthi Nachiappan +11 more
core +3 more sources
Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators. [PDF]
ACS Med Chem Lett, 2022 Sabnis RW.
europepmc +4 more sources
A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature
PLoS ONE, 2022 Chronic inflammation and blood–brain barrier dysfunction are key pathological hallmarks of neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. Major drivers of these pathologies include pro-inflammatory stimuli
Alicia M. Kemble +10 more
doaj +2 more sources
Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors. [PDF]
ACS Med Chem Lett, 2021 Sabnis RW.
europepmc +4 more sources
Future Foods, 2021 Pure concentrates of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids were used to produce monoacylglycerol and diacylglycerol (MDG) oils via enzymatic glycerolysis in a solvent-free system. Immobilized lipase from Candida antarctica B (Novozym 435)
Tharuka Gunathilake +2 more
doaj +1 more source
Heterocyclic Compounds as Monoacylglycerol Lipase (MAGL) Inhibitors. [PDF]
ACS Med Chem Lett, 2021 Sabnis RW.
europepmc +4 more sources