Results 11 to 20 of about 125,969 (167)

Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer

OncoImmunology, 2021
Monoacylglycerol lipase (MGL) expressed in cancer cells influences cancer pathogenesis but the role of MGL in the tumor microenvironment (TME) is less known.
M. Kienzl, Carina Hasenoehrl, K. Maitz, Arailym Sarsembayeva, Ulrike Taschler, P. Valadez-Cosmes, O. Kindler, Dusica Ristic, S. Raftopoulou, A. Santiso, T. Bärnthaler, L. Brčić, Lisa Hahnefeld, R. Gurke, Dominique Thomas, G. Geisslinger, J. Kargl, R. Schicho   +17 more
semanticscholar   +3 more sources

Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration. [PDF]

JHEP Rep, 2023
Background & Aims Liver regeneration is a repair process in which metabolic reprogramming of parenchymal and inflammatory cells plays a major role. Monoacylglycerol lipase (MAGL) is an ubiquitous enzyme at the crossroad between lipid metabolism and ...
Allaire M, Al Sayegh R, Mabire M, Hammoutene A, Siebert M, Caër C, Cadoux M, Wan J, Habib A, Le Gall M, de la Grange P, Guillou H, Postic C, Paradis V, Lotersztajn S, Gilgenkrantz H.   +15 more
europepmc   +2 more sources

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence. [PDF]

Nat Commun, 2023
Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated side effects ...
Jiang M, Huizenga MCW, Wirt JL, Paloczi J, Amedi A, van den Berg RJBHN, Benz J, Collin L, Deng H, Di X, Driever WF, Florea BI, Grether U, Janssen APA, Hankemeier T, Heitman LH, Lam TW, Mohr F, Pavlovic A, Ruf I, van den Hurk H, Stevens AF, van der Vliet D, van der Wel T, Wittwer MB, van Boeckel CAA, Pacher P, Hohmann AG, van der Stelt M.   +28 more
europepmc   +2 more sources

Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex. [PDF]

Nat Commun, 2023
The identification and characterization of enzyme function is largely lacking behind the rapidly increasing availability of large numbers of sequences and associated high-resolution structures.
Pinotsis N, Krüger A, Tomas N, Chatziefthymiou SD, Litz C, Mortensen SA, Daffé M, Marrakchi H, Antranikian G, Wilmanns M.   +9 more
europepmc   +2 more sources

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. [PDF]

J Med Chem, 2022
Monoacylglycerol lipase (MAGL) is the enzyme responsible for the metabolism of 2-arachidonoylglycerol in the brain and the hydrolysis of peripheral monoacylglycerols.
Bononi G, Di Stefano M, Poli G, Ortore G, Meier P, Masetto F, Caligiuri I, Rizzolio F, Macchia M, Chicca A, Avan A, Giovannetti E, Vagaggini C, Brai A, Dreassi E, Valoti M, Minutolo F, Granchi C, Gertsch J, Tuccinardi T.   +19 more
europepmc   +2 more sources

Endocannabinoid control of neuroinflammation in traumatic brain injury by monoacylglycerol lipase in astrocytes. [PDF]

Neural Regen Res, 2023
Traumatic brain injury (TBI) is a temporary or permanent disruption of brain function caused by external forces. TBI has been recognized as an important risk factor for the development of Alzheimer’s disease and dementia later in life.
Chen C.
europepmc   +2 more sources

Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators. [PDF]

ACS Med Chem Lett, 2022
Title. Aminocyclobutanes as Monoacylglycerol Lipase Modulators Patent Publication Number. WO 2021/191391 A1 U R L : h t t p s : / / p a t e n t s . g o o g l e . c o m / p a t e n t / WO2021191391A1/en Publication Date.
Sabnis RW.
europepmc   +2 more sources

β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia? [PDF]

Mol Pharmacol
The mechanisms of β-caryophyllene (BCP)-induced analgesia are not well studied. Here, we tested the efficacy of BCP in an acute postsurgical pain model and evaluated its effect on the endocannabinoid system. Rats were treated with vehicle and 10, 25, 50,
Klawitter J, Weissenborn W, Gvon I, Walz M, Klawitter J, Jackson M, Sempio C, Joksimovic SL, Shokati T, Just I, Christians U, Todorovic SM.   +11 more
europepmc   +2 more sources

Inhibition of triple negative breast cancer-associated inflammation, tumor growth and brain colonization by targeting monoacylglycerol lipase. [PDF]

Sci Rep, 2022
While the prevalence of breast cancer metastasis in the brain is significantly higher in triple negative breast cancers (TNBCs), there is a lack of novel and/or improved therapies for these patients. Monoacylglycerol lipase (MAGL) is a hydrolase involved
Benchama O, Tyukhtenko S, Malamas MS, Williams MK, Makriyannis A, Avraham HK.   +5 more
europepmc   +2 more sources

Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases. [PDF]

Molecules, 2021
Neurological and neurodegenerative diseases are debilitating conditions, and frequently lack an effective treatment. Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of 2-AG (2-arachidonoylglycerol), a neuroprotective ...
Zanfirescu A, Ungurianu A, Mihai DP, Radulescu D, Nitulescu GM.   +4 more
europepmc   +2 more sources