Results 21 to 30 of about 68,881 (203)

A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature

PLoS ONE, 2022
Chronic inflammation and blood–brain barrier dysfunction are key pathological hallmarks of neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. Major drivers of these pathologies include pro-inflammatory stimuli
Alicia M. Kemble, Benoit Hornsperger, Iris Ruf, Hans Richter, Jörg Benz, Bernd Kuhn, Dominik Heer, Matthias Wittwer, Britta Engelhardt, Uwe Grether, Ludovic Collin   +10 more
doaj   +2 more sources

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Geisslinger, Gerd, Gerd Geisslinger, Nowicki, Marcin, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Marcin Nowicki (109802), Ingo Bechmann (109810), Faramarz Dehghani (109822), Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Bechmann, Ingo, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Constance Hobusch, Ingo Bechmann, Kallendrusch, Sonja, Bechmann, Ingo Jürgen, Marcin Nowicki, Marco Koch, Angela Ehrlich (109799)   +27 more
core   +2 more sources

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer ...
Klaudia Barabas, Yanagawa, Yuchio, Harkany, Tibor, Giuseppe Tortoriello, Masaaki Torii, Cameron, Gary, Yuchio Yanagawa, Tortoriello, Giuseppe, Gary Cameron, Morozov, Yury M, Watanabe, Masahiko, Masahiko Watanabe, Barabas, Klaudia, Erik Keimpema, Ken Mackie, Keimpema, Erik, Tibor Harkany, Yury M. Morozov, Torii, Masaaki, Mackie, Ken, Watanabe, M, Harkany, T,, Cameron, G, Torii, M, Mackie, K, Tortoriello, G,, Keimpema, E,, Barabas, K, Yanagawa, Y, Morozov, YM   +29 more
core   +1 more source

Properties of acyl-coenzyme A:1-acylglycerophosphate acyltransferase and lipases in porcine erythrocyte membranes.

Journal of Lipid Research, 1984
Acyl-CoA:1-acylglycerophosphate acyltransferase activity was found in porcine erythrocyte membranes. However, the membrane preparations did not catalyze the acylation of either 2-acylglycerophosphate or 2-acylglycerophosphocholine.
M Mizuno, Y Sugiura, H Okuyama
doaj   +1 more source

Preparation of thioester substrates and development of continuous spectrophotometric assays for phospholipase A1 and monoacylglycerol lipase

Journal of Lipid Research, 1981
Current assays of phospholipase A1 (EC 3.1.1.32) and monoacylglycerol lipase (EC 3.1.1.23) activities in tissues are discontinuous, laborious, and expensive. Some spectrophotometric substrates were synthesized to alleviate this problem. Thioester analogs
J W Cox, L A Horrocks
doaj   +1 more source

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. [PDF]

J Med Chem, 2022
Monoacylglycerol lipase (MAGL) is the enzyme responsible for the metabolism of 2-arachidonoylglycerol in the brain and the hydrolysis of peripheral monoacylglycerols.
Bononi G, Di Stefano M, Poli G, Ortore G, Meier P, Masetto F, Caligiuri I, Rizzolio F, Macchia M, Chicca A, Avan A, Giovannetti E, Vagaggini C, Brai A, Dreassi E, Valoti M, Minutolo F, Granchi C, Gertsch J, Tuccinardi T.   +19 more
europepmc   +3 more sources

Glycerolysis of sardine oil catalyzed by a water dependent lipase in different tert-alcohols as reaction medium

Grasas y Aceites, 2015
The production of monoacylglycerol rich in polyunsaturated fatty acids (PUFA) via enzymatic glycerolysis of sardine oil in a homogeneous system was evaluated. Reactions were conducted in two different tert-alcohols.
Á. G. Solaesa, M. T. Sanz, R. Melgosa, S. L. Bucio, S. Beltrán   +4 more
doaj   +1 more source

Strategies to inhibit the lipid oxidation in the enzymatic synthesis of monoglycerides by glycerolysis of Babassu oil - doi: 10.4025/actascitechnol.v35i3.14187

Acta Scientiarum: Technology, 2013
Different strategies to avoid the lipid feedstock oxidation in the enzymatic synthesis of monoglycerides (MAG) from glycerolysis of babassu oil were tested. The reactions were catalyzed by Burkholderia cepacia lipase immobilized on SiO2-PVA and the tests
Larissa Freitas, Gisanara Dors, Bruna Curry Carneiro, Pedro Carlos de Oliveira, Heizir Ferreira De Castro   +4 more
doaj   +1 more source

Therapeutic potential of monoacylglycerol lipase inhibitors [PDF]

Life Sciences, 2013
Marijuana and aspirin have been used for millennia to treat a wide range of maladies including pain and inflammation. Both cannabinoids, like marijuana, that exert anti-inflammatory action through stimulating cannabinoid receptors, and cyclooxygenase (COX) inhibitors, like aspirin, that suppress pro-inflammatory eicosanoid production have shown ...
Melinda M, Mulvihill, Daniel K, Nomura
openaire   +2 more sources

Experimental and Modeling Studies of the Reaction Kinetics of Alkaline-Catalyzed used Frying Oil Glycerolysis using Isopropyl Alcohol as a Reaction Solvent [PDF]

, 2012
An alkaline catalyzed glycerolysis of used frying oil using sodium hydroxide and isopropyl alcohol as solvent was investigated. A reaction kinetic model considering glycerol-triglyceride solubility and a second order kinetic mechanism was also developed.
Kumoro, A.C.
core   +2 more sources