Results 21 to 30 of about 11,083 (203)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Monoacylglycerol Lipase Modulators for Treating Autism Spectrum Disorders. [PDF]

ACS Med Chem Lett, 2023
Provided herein are monoacylglycerol lipase modulators, pharmaceutical compositions, use of such compounds in treating autism spectrum disorders and processes for preparing such compounds.
Sabnis RW, Sabnis AR.
europepmc   +3 more sources

Spatially Resolved Mapping of Monoacylglycerol Lipase Activity in the Brain. [PDF]

ACS Chem Neurosci
Abstract Visualizing signaling systems in the brain with high spatial resolution is critical to understand brain function and to develop therapeutics. Especially enzymes are often regulated on the post-translational level, resulting in a disconnect between protein levels and activity.
van der Vliet D, Klinkenberg AXY, Platte R, Higgins K, Prokop S, Huizenga MCW, Kraaijevanger L, van Egmond N, Straub VM, Kole MHP, Pacher P, Katona I, Huitinga I, van der Stelt M.   +13 more
europepmc   +7 more sources

Therapeutic potential of monoacylglycerol lipase inhibitors [PDF]

Life Sciences, 2013
Marijuana and aspirin have been used for millennia to treat a wide range of maladies including pain and inflammation. Both cannabinoids, like marijuana, that exert anti-inflammatory action through stimulating cannabinoid receptors, and cyclooxygenase (COX) inhibitors, like aspirin, that suppress pro-inflammatory eicosanoid production have shown ...
Melinda M, Mulvihill, Daniel K, Nomura
openaire   +2 more sources

Association of MGLL Intronic C>T Single Nucleotide Polymorphism (rs782440) with Borderline Personality Disorder: A Case-Control Study [PDF]

Cell Journal, 2023
Objective: From the perspective of etiology, borderline personality disorder (BPD) is a multifactorial and complexdisorder, hence our understanding about the molecular basis and signaling of this disorder is extremely limited.The purpose of this study ...
Nazanin Hatami Bavarsad, Leila Jahangard, Masood Saidijam, Seyed Asaad Karimi, Ali Reza Soltanian, Elahe Shahriari, Saeid Afshar, Abdolrahman Sarihi   +7 more
doaj   +1 more source

The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation

Metabolites, 2020
The catabolism of intracellular triacylglycerols (TAGs) involves the activity of cytoplasmic and lysosomal enzymes. Cytoplasmic TAG hydrolysis, commonly termed lipolysis, is catalyzed by the sequential action of three major hydrolases, namely adipose ...
Peter Hofer, Ulrike Taschler, Renate Schreiber, Petra Kotzbeck, Gabriele Schoiswohl   +4 more
doaj   +1 more source

Hydrolysis of rat chylomicron acylglycerols: a kinetic model

Journal of Lipid Research, 1981
A quantitative model describing the kinetics of hydrolysis of rat chylomicron acylglycerols by bovine milk lipoprotein lipase has been developed using data from studies on rat lymph chylomicrons containing doubly labeled acylglycerols.
D M Foster, M Berman
doaj   +1 more source

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Geisslinger, Gerd, Gerd Geisslinger, Nowicki, Marcin, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Marcin Nowicki (109802), Ingo Bechmann (109810), Faramarz Dehghani (109822), Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Bechmann, Ingo, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Constance Hobusch, Ingo Bechmann, Kallendrusch, Sonja, Bechmann, Ingo Jürgen, Marcin Nowicki, Marco Koch, Angela Ehrlich (109799)   +27 more
core   +1 more source

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer ...
Klaudia Barabas, Yanagawa, Yuchio, Harkany, Tibor, Giuseppe Tortoriello, Masaaki Torii, Cameron, Gary, Yuchio Yanagawa, Tortoriello, Giuseppe, Gary Cameron, Morozov, Yury M, Watanabe, Masahiko, Masahiko Watanabe, Barabas, Klaudia, Erik Keimpema, Ken Mackie, Keimpema, Erik, Tibor Harkany, Yury M. Morozov, Torii, Masaaki, Mackie, Ken   +19 more
core   +1 more source

Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism

Cell Reports, 2020
Summary: Under caloric restriction, bone marrow adipocytes (BM-Ads) do not decrease in size compared to white adipocytes, suggesting they harbor unique metabolic properties.
Camille Attané, David Estève, Karima Chaoui, Jason S. Iacovoni, Jill Corre, Mohamed Moutahir, Philippe Valet, Odile Schiltz, Nicolas Reina, Catherine Muller   +9 more
doaj   +1 more source