Results 1 to 10 of about 5,510 (189)

Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors

Journal of Lipid Research, 2016
Lipids are used as cellular building blocks and condensed energy stores and also act as signaling molecules. The glycerolipid/ fatty acid cycle, encompassing lipolysis and lipogenesis, generates many lipid signals.
Jose Iglesias, Julien Lamontagne, Heidi Erb, Sari Gezzar, Shangang Zhao, Erik Joly, Vouy Linh Truong, Kathryn Skorey, Sheldon Crane, S.R.Murthy Madiraju, Marc Prentki   +10 more
doaj   +1 more source

Discrimination against diacylglycerol ethers in lipase-catalysed ethanolysis of shark liver oil [PDF]

, 2013
This is the author’s version of a work that was accepted for publication in Food Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be ...
Fernández, Óscar, Reglero, Guillermo, Torres, Carlos F., Vázquez, Luis Nuñez   +3 more
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Hydrolysis of coconut oil (Cocos nucífera L.) by specificity and no positional specificity enzimes.

Grasas y Aceites, 1997
The characteristic fatty acid composition of coconut oil provides mainly short- and medium- chain fatty acids when incorporated to the diet. These fatty acids have nutritional advantages because their metabolic disposition allows the rapid obtention of ...
R. Rodríguez, J. Sanhueza, A. Valenzuela, S. Nieto   +3 more
doaj   +1 more source

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer reviewedPublisher ...
Barabas, Klaudia, Cameron, Gary, Harkany, Tibor, Keimpema, Erik, Mackie, Ken, Morozov, Yury M, Torii, Masaaki, Tortoriello, Giuseppe, Watanabe, Masahiko, Yanagawa, Yuchio   +9 more
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Monoacylglycerol-enriched oil increases EPA/DHA delivery to circulatory system in humans with induced lipid malabsorption conditions1

Journal of Lipid Research, 2016
It was hypothesized that under induced lipid malabsorption/maldigestion conditions, an enriched sn-1(3)-monoacylglycerol (MAG) oil may be a better carrier for n-3 long-chain PUFAs (LC-PUFAs) compared with triacylglycerol (TAG) from fish oil.
Cristina Cruz-Hernandez, Frédéric Destaillats, Sagar K. Thakkar, Laurence Goulet, Emma Wynn, Dominik Grathwohl, Claudia Roessle, Sara de Giorgi, Luc Tappy, Francesca Giuffrida, Vittorio Giusti   +10 more
doaj   +1 more source

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

Journal of Lipid Research, 2012
In the central nervous system, three enzymes belonging to the serine hydrolase family are thought to regulate the life time of the endocannabinoid 2-arachidonoylglycerol (C20:4) (2-AG). From these, monoacylglycerol lipase (MAGL) is well characterized and,
Dina Navia-Paldanius, Juha R. Savinainen, Jarmo T. Laitinen   +2 more
doaj   +1 more source

Development of a versatile laboratory experiment to teach the metabolic transformation of hydrolysis [PDF]

, 2016
In this paper we describe an easy, reliable, versatile and inexpensive laboratory experiment to teach the metabolic transformation of hydrolysis to Pharmacy students.
Badyal, D.K., Desai, C., Bailey, D.G., Dresser, G., Arnold, J.M.O., Bailey, D.G., Malcolm, J., Arnold, O., Spence, J. D., Barry, E., Borer, L., Bemback, S., Blackberg, L., Hemell, O., Braiuca, P., Lorena, K., Ferrario, V., Ebert, C., Gardossia, L., Clay, M.D., McLeod, E.J., Fojan, P., Jonson, P.H. Petersen, M.T.N., Steffen B., Petersen, S.B., Fuentes, G., Ballesteros, A., Verma, C.S., Fukami, T., Yokoi, T., Herrier, R.N., Jackson, T.R., Consroe, P.F., Mattson, F.H., Beck, L.W., Ogu, C.C., Maxa, J.L., Qayed, W.S., Aboraia, A.S., Abdel-Rahman, H.M., Youssef, A.F., Rautio, J., Kumpulainen, H., Heimbach T., Oliyai, R., Oh, D., Järvinen, T., Savolainen, J., Rengachari, S., Aschauer, P., Schittmayer, M., Mayer, N., Gruber, K., Breinbauer, R., Birner-Gruenberger, R., Dreveny, I., Oberer, M., Toone, E.J., Werth, M.J., Jones, J.B., Ward, L.C., Reilly, P.E.B.   +17 more
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N-terminal domain replacement changes an archaeal monoacylglycerol lipase into a triacylglycerol lipase

Biotechnology for Biofuels, 2019
Background Lipolytic enzymes of hyperthermophilic archaea generally prefer small carbon chain fatty acid esters (C2–C12) and are categorized as esterases.
Surabhi Soni, Sneha S. Sathe, Rutuja R. Sheth, Prince Tiwari, Rajesh-Kumar N. Vadgama, Annamma Anil Odaneth, Arvind M. Lali, Sanjeev K. Chandrayan   +7 more
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Acetyl-11-keto-β-boswellic acid alleviates hepatic metabolic dysfunction by inhibiting MGLL activity

Journal of Lipid Research
Metabolic abnormalities have emerged as a central pathogenesis in various metabolic diseases, particularly nonalcoholic fatty liver disease (NAFLD) and its associated complications of obesity and insulin resistance. Despite this, effective pharmaceutical
Kai Luan, Yuhong Fan, Qin Yang, Hailong Yang, Zelin Zhou, Ju Huang, Zhigang She, Toujun Zou, Hui Xiong, Zhinan Mei   +9 more
doaj   +1 more source

Storage oil hydrolysis during early seedling growth [PDF]

, 2009
Storage oil breakdown plays an important role in the life cycle of many plants by providing the carbon skeletons that support seedling growth immediately following germination.
Andrews, Anne-Laure Quettier, Athenstaedt, Athenstaedt, Baker, Beisson, Chia, Ducharme, Eastmond, Eastmond, Eastmond, El-Kouhen, Fernandez, Frandsen, Fuchs, Fuchs, Ghosh, Ghosh, Graham, Grönke, Gupta, Hayashi, Hellyer, Hills, Hills, Hills, Huang, Ishiguro, Jennens, Jolivet, Kurat, Lass, Lin, Lin, Maeshima, Matsui, May, Mhaske, Mukherjee, Murphy, Murphy, Ncube, Noll, Ohlrogge, Ollis, Peter J. Eastmond, Poxleitner, Quettier, Robenek, Rydel, Schweiger, Siloto, Somerville, Stahl, Ubersax, Wanner, Zimmermann   +56 more
core   +1 more source