Results 21 to 30 of about 3,551 (187)

Label-free measurement of the yeast short chain TAG lipase activity by ESI-MS after one-step esterification

Journal of Lipid Research, 2017
Triacylglycerol (TAG) lipases hydrolyze ester bonds in TAG and release diacylglycerol (DAG), monoacylglycerol (MAG), and FA. We present a one-step chemical derivatization method for label-free quantification of a mixture of TAG, DAG, and MAG following ...
Hye Jin Ham, Jongcheol Seo, Hye-Joo Yoon, Seung Koo Shin   +3 more
doaj   +1 more source

Monoacylglycerol Lipase Regulates Fever Response

PLOS ONE, 2015
Cyclooxygenase inhibitors such as ibuprofen have been used for decades to control fever through reducing the levels of the pyrogenic lipid transmitter prostaglandin E2 (PGE2). Historically, phospholipases have been considered to be the primary generator of the arachidonic acid (AA) precursor pool for generating PGE2 and other eicosanoids.
Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Gianluca Moroncini, Andreu Viader, Daniel K Nomura, Benjamin F Cravatt, Bruno Conti   +7 more
openaire   +4 more sources

Inhibitors of monoacylglycerol lipase as novel analgesics [PDF]

British Journal of Pharmacology, 2007
2‐Arachidonoylglycerol (2‐AG) is an endogenous cannabinoid (endocannabinoid) lipid whose functions remain poorly understood. Guindon and colleagues report the novel finding that exogenous application of 2‐AG induces peripheral antinociceptive effects that are mediated, at least in part, by actions at peripheral cannabinoid CB2 receptors.
openaire   +2 more sources

Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors

Journal of Lipid Research, 2016
Lipids are used as cellular building blocks and condensed energy stores and also act as signaling molecules. The glycerolipid/ fatty acid cycle, encompassing lipolysis and lipogenesis, generates many lipid signals.
Jose Iglesias, Julien Lamontagne, Heidi Erb, Sari Gezzar, Shangang Zhao, Erik Joly, Vouy Linh Truong, Kathryn Skorey, Sheldon Crane, S.R.Murthy Madiraju, Marc Prentki   +10 more
doaj   +1 more source

Monoacylglycerol lipase: stopping surplus at the synapse

The Journal of Physiology, 2011
Endocannabinoids (eCBs) are a family of molecules derived from membrane phospholipids which exert biological effects through specific receptors. In the brain, eCBs are perhaps the most ubiquitous and potent neurotransmitters known to act in a retrograde manner.
Jaclyn I, Wamsteeker, Jaideep S, Bains
openaire   +3 more sources

Distribution and function of monoacylglycerol lipase in the gastrointestinal tract [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2008
The endogenous cannabinoid system plays an important role in the regulation of gastrointestinal function in health and disease. Endocannabinoid levels are regulated by catabolic enzymes. Here, we describe the presence and localization of monoacylglycerol lipase (MGL), the major enzyme responsible for the degradation of 2-arachidonoylglycerol.
Duncan, Marnie, Thomas, Adam D, Cluny, Nina L, Patel, Annie, Patel, Kamala D, Lutz, Beat, Piomelli, Daniele, Alexander, Stephen PH, Sharkey, Keith A   +8 more
openaire   +4 more sources

Hydrolysis of coconut oil (Cocos nucífera L.) by specificity and no positional specificity enzimes.

Grasas y Aceites, 1997
The characteristic fatty acid composition of coconut oil provides mainly short- and medium- chain fatty acids when incorporated to the diet. These fatty acids have nutritional advantages because their metabolic disposition allows the rapid obtention of ...
R. Rodríguez, J. Sanhueza, A. Valenzuela, S. Nieto   +3 more
doaj   +1 more source

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer ...
Klaudia Barabas, Yanagawa, Yuchio, Harkany, Tibor, Giuseppe Tortoriello, Masaaki Torii, Cameron, Gary, Yuchio Yanagawa, Tortoriello, Giuseppe, Gary Cameron, Morozov, Yury M, Watanabe, Masahiko, Masahiko Watanabe, Barabas, Klaudia, Erik Keimpema, Ken Mackie, Keimpema, Erik, Tibor Harkany, Yury M. Morozov, Torii, Masaaki, Mackie, Ken   +19 more
core   +1 more source

Enzymatic esterification of free fatty acids in vegetable oils utilizing different immobilized lipases

, 2022
S.169-174Different immobilized lipases were screened for their ability to esterify free fatty acids (FFA) with monoacylglycerol (MAG) as acyl-group acceptor.
Schweiggert-Weisz, Ute, Haar, Daniela von der, Stäbler, Andreas, Wichmann, Rolf   +3 more
core   +1 more source

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

Journal of Lipid Research, 2012
In the central nervous system, three enzymes belonging to the serine hydrolase family are thought to regulate the life time of the endocannabinoid 2-arachidonoylglycerol (C20:4) (2-AG). From these, monoacylglycerol lipase (MAGL) is well characterized and,
Dina Navia-Paldanius, Juha R. Savinainen, Jarmo T. Laitinen   +2 more
doaj   +1 more source