Results 31 to 40 of about 5,510 (189)

A First Attempt into the Production of Acylglycerol Mixtures from Echium Oil [PDF]

, 2016
Enzymatic glycerolysis of Echium oil (Echium plantagineum) has been carried out in the presence of four commercial lipases. Different pretreatments of the reaction mixture, such as high pressure homogenization and addition of food grade monoolein as an ...
Alejandro eJordán, Carlos F Torres, Guillermo eReglero, Guillermo eReglero, Luis eVázquez   +4 more
core   +3 more sources

Monoacylglycerol Lipase Regulates Fever Response

PLOS ONE, 2015
Cyclooxygenase inhibitors such as ibuprofen have been used for decades to control fever through reducing the levels of the pyrogenic lipid transmitter prostaglandin E2 (PGE2). Historically, phospholipases have been considered to be the primary generator of the arachidonic acid (AA) precursor pool for generating PGE2 and other eicosanoids.
Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Gianluca Moroncini, Andreu Viader, Daniel K Nomura, Benjamin F Cravatt, Bruno Conti   +7 more
openaire   +4 more sources

Characteristics of a Monoacylglycerol Lipase Isolated from Pseudomonas sp. LP7315 -Hydrolysis and Synthesis of Monoglycerides [PDF]

, 2001
A monoacylglycerol lipase (MGL) was purified from Pseudomonas sp. LP7315 by ammonium sulfate precipitation, anion-exchange chromatography, and preparative electrophoresis.
Miyake, Akira, Nakanishi, Kazuhiro, Ozaki, Sho, Sakiyama, Takaharu, Tanaka, Atsushi, Umeoka, Midori, Yoshimi, Tsuyoshi   +6 more
core   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Production of a biodiesel-like biofuel without glycerol generation, by using Novozym 435, an immobilized lipase [PDF]

, 2014
Background: Novozym 435, a commercial lipase from Candida antarctica, recombinant, expressed in Aspergillus niger, immobilized on macroporous acrylic resin, has been already described in the obtention of biodiesel.
Bautista, F.M., Calero, Juan, Luna, Carlos, Luna, Diego, Posadillo, Alejandro, Romero, Antonio A., Sancho, Enrique D., Verdugo-Escamilla, Cristóbal   +7 more
core   +3 more sources

Arachis hypogaea monoacylglycerol lipase AhMAGL3b participates in lipid metabolism. [PDF]

BMC Plant Biol
Monoacylglycerol lipase (MAGL) belongs to the serine hydrolase family; it catalyzes MAG to produce glycerol and free fatty acids (FFAs), which is the final step in triacylglycerol (TAG) hydrolysis. The effects of MAGL on comprehensive lipid metabolism and plant growth and development have not been elucidated, especially in Arachis hypogaea, an ...
Zhan Y, Wang J, Zhao X, Zheng Z, Gan Y.
europepmc   +4 more sources

Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors [PDF]

Chemistry & Biology, 2009
Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Previous efforts to design MGL inhibitors have focused on chemical scaffolds that irreversibly block the activity of this enzyme.
KING AR, DOTSEY EY, JUNG KM, GHOMIAN A, QIU Y, FU J, PIOMELLI D., LODOLA, Alessio, MOR, Marco   +8 more
openaire   +3 more sources

Inhibitors of monoacylglycerol lipase as novel analgesics [PDF]

British Journal of Pharmacology, 2007
2‐Arachidonoylglycerol (2‐AG) is an endogenous cannabinoid (endocannabinoid) lipid whose functions remain poorly understood. Guindon and colleagues report the novel finding that exogenous application of 2‐AG induces peripheral antinociceptive effects that are mediated, at least in part, by actions at peripheral cannabinoid CB2 receptors.
openaire   +2 more sources

Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase [PDF]

Journal of Biological Chemistry, 2013
Monoacylglycerol lipases (MGLs) play an important role in lipid catabolism across all kingdoms of life by catalyzing the release of free fatty acids from monoacylglycerols. The three-dimensional structures of human and a bacterial MGL were determined only recently as the first members of this lipase family.
Rengachari S., Aschauer P., Schittmayer M., Mayer N., Gruber K., Breinbauer R., Birner-Gruenberger R., Dreveny I., Oberer M.   +8 more
openaire   +3 more sources

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives

Journal of Medicinal Chemistry, 2022
Monoacylglycerol lipase (MAGL) is the enzyme responsible for the metabolism of 2-arachidonoylglycerol in the brain and the hydrolysis of peripheral monoacylglycerols. Many studies demonstrated beneficial effects deriving from MAGL inhibition for neurodegenerative diseases, inflammatory pathologies, and cancer.
Giulia Bononi, Miriana Di Stefano, Giulio Poli, Gabriella Ortore, Philip Meier, Francesca Masetto, Isabella Caligiuri, Flavio Rizzolio, Marco Macchia, Andrea Chicca, Amir Avan, Elisa Giovannetti, Chiara Vagaggini, Annalaura Brai, Elena Dreassi, Massimo Valoti, Filippo Minutolo, Carlotta Granchi, Jürg Gertsch, Tiziano Tuccinardi   +19 more
openaire   +5 more sources