Results 31 to 40 of about 3,551 (187)

Monoacylglycerol lipase – a target for drug development? [PDF]

British Journal of Pharmacology, 2012
The endocannabinoid (eCB) system is involved in processes as diverse as control of appetite, perception of pain and the limitation of cancer cell growth and invasion. The enzymes responsible for eCB breakdown are attractive pharmacological targets, and fatty acid amide hydrolase inhibitors, which potentiate the levels of the eCB anandamide, are now ...
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Inhibition of monoacylglycerol lipase reduces nicotine withdrawal [PDF]

British Journal of Pharmacology, 2015
Background and PurposeAbrupt discontinuation of nicotine, the main psychoactive component in tobacco, induces a withdrawal syndrome in nicotine‐dependent animals, consisting of somatic and affective signs, avoidance of which contributes to drug maintenance.
P P, Muldoon, J, Chen, J L, Harenza, R A, Abdullah, L J, Sim-Selley, B F, Cravatt, M F, Miles, X, Chen, A H, Lichtman, M I, Damaj   +9 more
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N-terminal domain replacement changes an archaeal monoacylglycerol lipase into a triacylglycerol lipase

Biotechnology for Biofuels, 2019
Background Lipolytic enzymes of hyperthermophilic archaea generally prefer small carbon chain fatty acid esters (C2–C12) and are categorized as esterases.
Surabhi Soni, Sneha S. Sathe, Rutuja R. Sheth, Prince Tiwari, Rajesh-Kumar N. Vadgama, Annamma Anil Odaneth, Arvind M. Lali, Sanjeev K. Chandrayan   +7 more
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Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors [PDF]

Chemistry & Biology, 2009
Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Previous efforts to design MGL inhibitors have focused on chemical scaffolds that irreversibly block the activity of this enzyme.
KING AR, DOTSEY EY, JUNG KM, GHOMIAN A, QIU Y, FU J, PIOMELLI D., LODOLA, Alessio, MOR, Marco   +8 more
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Purification and properties of a monoacylglycerol lipase in human erythrocytes [PDF]

Biochemical Journal, 1995
A membrane-bound monoacylglycerol lipase (MAGL) activity, previously demonstrated in intact human erythrocytes [Boyer, Somma, Vérine, L'Hôte, Finidori, Merger and Arnaud (1981) J. Clin. Endocrinol. Metab. 53, 143-148], has now been purified to apparent homogeneity by a five-step procedure involving solubilization in CHAPS and sequential ...
C, Somma-Delpéro, A, Valette, J, Lepetit-Thévenin, O, Nobili, J, Boyer, A, Vérine   +5 more
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Acetyl-11-keto-β-boswellic acid alleviates hepatic metabolic dysfunction by inhibiting MGLL activity

Journal of Lipid Research
Metabolic abnormalities have emerged as a central pathogenesis in various metabolic diseases, particularly nonalcoholic fatty liver disease (NAFLD) and its associated complications of obesity and insulin resistance. Despite this, effective pharmaceutical
Kai Luan, Yuhong Fan, Qin Yang, Hailong Yang, Zelin Zhou, Ju Huang, Zhigang She, Toujun Zou, Hui Xiong, Zhinan Mei   +9 more
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Kinetic modeling of lipase-catalysed hydrolysis of triacylglycerol in a reverse micelle system for the determination of integral stereoselectivity

, 2022
A kinetic model describing the integral stereoselectivity of lipase, which refers to selectivities for all positions of triacylglycerol, diacylglycerol, and monoacylglycerol isomers, was developed.
Choi, Yoonseok, Chang, Pahn-Shick
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Of Mice and MAGL (Monoacylglycerol Lipase)

The FASEB Journal, 2011
About 18.8 million American adults suffer depressive disorders that may occur with anxiety and substance abuse. Tetrahydrocannabinol (THC), a compound in marijuana, is a cannabinoid chemical that binds to and activates cannabinoid receptors (CB1) in the pre‐synaptic cell membrane as part of neuron‐to‐neuron transmission in the ...
S. Bach, T. Bombinski, M. Daniels, D. Gross, T. Hogg, T. Martin, D. McMurray, E. Naber, N. Perez, A. Schulman, S. Tucker, S. Andera‐Cato, A. Arnold, A. Blumberg, M. Bord, A. Feiertag, M. Greaves, A. Her, E. Kennedy, C. Orozco, C. Rice, A. Rodgers, A. Sauer, J. Schubert, C. Tubbs, T. Wray, G. Vogt, L. Shrestha, C. Hillard   +28 more
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Conformational gating, dynamics and allostery in human monoacylglycerol lipase [PDF]

Scientific Reports, 2020
AbstractInhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting active-inactive conformational transitions of the enzyme, can be aided by understanding the interplay between structure and dynamics.
Tyukhtenko, Sergiy, Ma, Xiaoyu, Rajarshi, Girija, Karageorgos, Ioannis, Anderson, Kyle W., Hudgens, Jeffrey W., Guo, Jason J., Nasr, Mahmoud L., Zvonok, Nikolai, Vemuri, Kiran, Wagner, Gerhard, Makriyannis, Alexandros   +11 more
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Preparação de ésteres de aroma catalisada por lipases imobilizadas em filmes de amido/PVA [PDF]

, 2010
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.Neste trabalho, foi efetuada a imobilização de lipases de diversas procedências em filmes de amido de mandioca e de amido/PVA (poli ...
Gris, Daiane
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