Results 61 to 70 of about 20,213 (210)

Effect of inhibition of fatty acid amide hydrolase on MPTP-induced dopaminergic neuronal damage

Neurología (English Edition), 2019
Introduction: Parkinson's disease is a neurodegenerative disorder characterised by balance problems, muscle rigidity, and slow movement due to low dopamine levels and loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc).
J.M. Viveros-Paredes, R.E. Gonzalez-Castañeda, A. Escalante-Castañeda, A.R. Tejeda-Martínez, F. Castañeda-Achutiguí, M.E. Flores-Soto   +5 more
doaj   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, EarlyView.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10‐2474

British Journal of Pharmacology, 2020
In 2016, one person died and four others had mild‐to‐severe neurological symptoms during a phase I trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10‐2474.
M. Bonifácio, Filipa Sousa, C. Aires, A. Loureiro, C. Fernandes‐Lopes, N. Pires, P. Palma, P. Moser, P. Soares‐da‐Silva   +8 more
semanticscholar   +1 more source

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an ...
Naresh Sunduru, Mona Svensson, Mariateresa Cipriano, Sania Marwaha, C. David Andersson, Richard Svensson, Christopher J. Fowler, Mikael Elofsson   +7 more
doaj   +1 more source

Chemical Recycling as a Tool for Enabling a Second Life for Polyesters

SusMat, EarlyView.
This review presents the elucidation of the life cycle of main polyesters, detailing end‐of‐life methods, with focus of solvolysis technologies, then an analysis of LCA and TEA on literature data, an original data analytic, and, finally, a current industrial mapping of the main processes with a critical perspective on the plastic life‐cycle ecosystem ...
Nícolas Soares Urruth, Cristian de Oliveira Romera, Caio Gomide Otoni, Bruno Francisco Oechsler, Pedro Henrique Hermes de Araújo, Claudia Sayer   +5 more
wiley   +1 more source

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

Frontiers in Neuroscience, 2018
The endocannabinoid system (ECS) is considered to be an endogenous protective system in various neurodegenerative diseases. Niemann-Pick type C (NPC) is a neurodegenerative disease in which the role of the ECS has not been studied yet.
Eva J. van Rooden, Annelot C. M. van Esbroeck, Marc P. Baggelaar, Hui Deng, Bogdan I. Florea, André R. A. Marques, Roelof Ottenhoff, Rolf G. Boot, Herman S. Overkleeft, Johannes M. F. G. Aerts, Mario van der Stelt   +10 more
doaj   +1 more source

Chinese Herbal Medicine (MaZiRenWan) Improves Bowel Movement in Functional Constipation Through Down-Regulating Oleamide

Frontiers in Pharmacology, 2020
In a prospective, randomized, three-arms, controlled clinical study, Chinese Herbal Medicine MaZiRenWan (MZRW, also known as Hemp Seed Pill) demonstrates comparable efficacy with Senna for functional constipation (FC) during an 8-week treatment period ...
Tao Huang, Ling Zhao, Cheng-Yuan Lin, Cheng-Yuan Lin, Lin Lu, Zi-Wan Ning, Dong-Dong Hu, Linda L. D. Zhong, Linda L. D. Zhong, Zhi-Jun Yang, Zhao-Xiang Bian, Zhao-Xiang Bian   +11 more
doaj   +1 more source

Antihyperalgesic effect of joint mobilization requires Cav3.2 calcium channels

Molecular Brain, 2023
The present study was undertaken to explore the relative contributions of Cav3.2 T-type channels to mediating the antihyperalgesic activity of joint manipulation (JM) therapy.
Daniel F. Martins, Victor Sorrentino, Leidiane Mazzardo-Martins, William R. Reed, Adair R. S. Santos, Vinícius M. Gadotti, Gerald W. Zamponi   +6 more
doaj   +1 more source