Results 41 to 50 of about 13,359 (214)

Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition

Cells, 2022
Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease” electing multitarget compounds as potential therapeutic tools suitable for the treatment of complex diseases, such as metabolic syndrome, psychiatric or degenerative
Alessandro Papa, Silvia Pasquini, Chiara Contri, Sandra Gemma, Giuseppe Campiani, Stefania Butini, Katia Varani, Fabrizio Vincenzi   +7 more
doaj   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain [PDF]

, 2006
Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Richardson, Denise, Chapman, Victoria, Jhaveri, Maulik, Kendall, David, Barrett, David   +4 more
core  

The fatty acid amide hydrolase inhibitor oleoyl ethyl amide counteracts bladder overactivity in female rats.

, 2014
To study micturition and bladder overactivity in female rats after chronic treatment with the fatty acid amide hydrolase (FAAH) inhibitor oleoyl ethyl amide (OEtA)
Bettiga, A.,, Castiglione, F.,, Stief, C.,, Mistretta, Francesco, Benigni, Fabio, Castiglione, Fabio, Moschini, M.,, Stief, Christian, Benigni, F.,, Hedlund, Petter,, La Croce, G.,, Strittmatter, Frank, Gratzke, C.,, La Croce, Giovanni, Montorsi, Francesco, Gandaglia, Giorgio, Mistretta, F.,, Montorsi, F.,, Moschini, Marco, Hedlund, Petter, Gratzke, Christian, Strittmatter, F.,, Lund University., Gandaglia, G.,, Bettiga, Arianna   +24 more
core   +1 more source

Lipid Profiling Reveals Tissue-Specific Differences for N-Acylethanolamines and their Precursors in Mice Lacking Fatty Acid Amide Hydrolase [PDF]

, 2010
Article on lipid profiling revealing tissue-specific differences for N-acylethanolamines and their precursors in mice lacking fatty acid amide ...
Koulen, Peter, Kilaru, Aruna, Isaac, Giorgis, Aruna Kilaru, Duncan, Scott R., Baxter, David, Scott R. Duncan, Barney J. Venables, Chapman, Kent D., Giorgis Isaac, Pamela Tamura, Kent D. Chapman, Venables, Barney J., Tamura, Pam, Welti, Ruth, Peter Koulen, David Baxter, Ruth Welti   +17 more
core   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Effect of inhibition of fatty acid amide hydrolase on MPTP-induced dopaminergic neuronal damage

Neurología (English Edition), 2019
Introduction: Parkinson's disease is a neurodegenerative disorder characterised by balance problems, muscle rigidity, and slow movement due to low dopamine levels and loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc).
J.M. Viveros-Paredes, R.E. Gonzalez-Castañeda, A. Escalante-Castañeda, A.R. Tejeda-Martínez, F. Castañeda-Achutiguí, M.E. Flores-Soto   +5 more
doaj   +1 more source

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

Fatty acid amide hydrolase (FAAH) activity.

, 2015
Data are expressed as mean ± SEM (pmol/min per mg protein). Animals were orally administered ST4070 (or the corresponding vehicle) 60 min before the behavioural test (LD box, see text for details).
Cinzia Rapino (302622), Franco Borsini (319923), Eva M. Marco (479544), Giovanni Laviola (149568), Antonio Caprioli (794464), Mauro Maccarrone (276174)   +5 more
core   +1 more source