Results 41 to 50 of about 20,213 (210)

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +2 more sources

Assessment of the effects of CNR1, FAAH and MGLL gene variations on the synthetic cannabinoid use disorder

Türk Biyokimya Dergisi, 2023
Given that drug addiction occurs as a result of complex gene-environment interaction, a number of studies claimed that cannabinoid receptor 1 (CNR1), fatty acid amide hydrolase (FAAH), and monoacylglycerol lipase (MGLL) single nucleotide polymorphisms ...
Altun Beril, Cok Ismet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source

Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.

PLoS ONE, 2014
BackgroundThe endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake ...
Emmelie Björklund, Anders Blomqvist, Joel Hedlin, Emma Persson, Christopher J Fowler   +4 more
doaj   +1 more source

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro

BMC Pharmacology and Toxicology, 2022
Background Pain relief remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far have low to moderate efficiencies with significant untoward side effects. FAAH-1 has been proposed as a
Julius T. Dongdem, Gideon K. Helegbe, Kwame Opare-Asamoah, Cletus A. Wezena, Augustine Ocloo   +4 more
doaj   +1 more source

Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [11C]CURB positron emission tomography study

Neuropsychopharmacology, 2020
Amygdala-prefrontal cortex (PFC) functional impairments have been linked to emotion dysregulation and aggression in borderline personality disorder (BPD).
N. Kolla, R. Mizrahi, Romina Mizrahi, K. Karas, C. Wang, R. Bagby, R. Bagby, S. McMain, Shelley McMain, A. Simpson, A. Simpson, P. Rusjan, P. Rusjan, Rachel F. Tyndale, R. Tyndale, Sylvain Houle, Sylvain Houle, I. Boileau, I. Boileau   +18 more
semanticscholar   +1 more source

Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase

Neuropsychopharmacology, 2021
Peripheral inflammatory conditions, including those localized to the gastrointestinal tract, are highly comorbid with psychiatric disorders such as anxiety and depression.
Haley A. Vecchiarelli, M. Morena, C. Keenan, Vincent Chiang, K. Tan, Min Qiao, Kira D. Leitl, Alessia Santori, Q. Pittman, K. Sharkey, Matthew N Hill   +10 more
semanticscholar   +1 more source

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase

Molecules, 2016
Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties.
Yan Qiu, Yang Zhang, Yuhang Li, Jie Ren
doaj   +1 more source

Kaempferol Facilitated Extinction Learning in Contextual Fear Conditioned Rats via Inhibition of Fatty-Acid Amide Hydrolase

Molecules, 2020
Background: Fear, stress, and anxiety-like behaviors originate from traumatic events in life. Stress response is managed by endocannabinoids in the body by limiting the uncontrolled retrieval of aversive memories.
Hammad Ahmad, K. Rauf, Wahid Zada, M. McCarthy, G. Abbas, Fareeha Anwar, A. Shah   +6 more
semanticscholar   +1 more source

Inhibition of Fatty Acid Amide Hydrolase by Chlorpyrifos in Juvenile Rats Results in Altered Exploratory and Social Behavior as Adolescents

Neurotoxicology, 2020
The organophosphorus insecticide chlorpyrifos (CPF) is suspected to cause developmental neurotoxicity in children leading to long term effects. Developmental exposure of rat pups to CPF at low levels disrupts degradation of the brain endocannabinoids ...
R. Carr, N. Alugubelly, Kathryne de Leon, L. Loyant, A. Mohammed, M. Patterson, M. Ross, Nicole E. Rowbotham   +7 more
semanticscholar   +1 more source

Predicting the bioactive compounds of Lentinula edodes and elucidating its interaction with genes associated to obesity through network pharmacology and in-vitro cell-based assay

Heliyon
Mushrooms are traditionally used for various medicinal purposes in traditional oriental medicine. The Japanese and Chinese are familiar with the medicinal macro fungus Lentinula edodes (Shiitake mushroom). This study aims to evaluate the role of chemical
Jasmeet Kaur, Humaira Farooqi, Kailash Chandra, Bibhu Prasad Panda   +3 more
doaj   +1 more source