Results 1 to 10 of about 6,564 (133)

Fatty Acid Amide Hydrolase Signaling and Ovarian Disorders: From Molecular Mechanism to Clinical Significance [PDF]

Molecules
Fatty acid amide hydrolase (FAAH) is a central component of the endocannabinoid system (ECS), where it primarily regulates intracellular levels of anandamide (AEA) through enzymatic hydrolysis.
Qinghe Lin, Zhenghong Zhang, Defan Wang, Fan Wang, Zhengchao Wang   +4 more
doaj   +2 more sources

FAAH rs324420 Polymorphism in People With Opioid and Methamphetamine Use Disorders: Psychological Associations. [PDF]

Brain Behav
This study explored the association between the FAAH rs324420 polymorphism and substance use disorders in individuals with methamphetamine, opioid, and combined use. The rs324420 CA genotype was linked to a reduced risk of substance use disorder, while higher craving scores were observed in individuals with combined opioid–methamphetamine use. ABSTRACT
Erekli-Arat Ö, Tepe M, Özkan-Kotiloğlu S, Danışman M, Kaya-Akyüzlü D.   +4 more
europepmc   +2 more sources

Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model. [PDF]

FASEB J
A new galvanic skin response‐based approach offers a simple method for measuring sweating in the paws of mice. This method is used to demonstrate that cannabinoid CB1 receptors reduce baseline sweating in mice, likely via inhibition of sympathetic acetylcholine release via axonal CB1 receptors.
Murataeva N, Youkilis J, Rao Y, Straiker A.   +3 more
europepmc   +2 more sources

Identification of quinolinyl-containing dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors with moderate potency towards acetylcholinesterase [PDF]

Results in Chemistry
Using a polypharmacological approach, we designed two different quinolinyl libraries by merging the pharmacophores of three targeted enzymes, fatty acid amide hydrolase (FAAH), soluble epoxide hydrolase (sEH), and acetylcholinesterase (AChE).
Michael Gonzalez, Ryan West, Amanda Tsang, Olivia Ocampo, Paula K. Hudson, Stevan Pecic   +5 more
doaj   +2 more sources

Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study. [PDF]

Addiction
Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
García-Gutiérrez MS, Torregrosa AB, Navarrete F, Aracil-Fernández A, Rubio G, Manzanares J.   +5 more
europepmc   +2 more sources

A preliminary investigation of tobacco co-use on endocannabinoid activity in people with cannabis use [PDF]

Drug and Alcohol Dependence Reports
Tobacco is commonly co-used with cannabis. This is unfortunate because tobacco co-use exacerbates select clinical consequences associated with cannabis use.
Rachel A. Rabin, Joseph Farrugia, Ranjini Garani, Romina Mizrahi, Pablo Rusjan   +4 more
doaj   +2 more sources

A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice

eLife, 2023
Fatty acid amide hydrolase (FAAH) degrades the endocannabinoid anandamide. A polymorphism in FAAH (FAAH C385A) reduces FAAH expression, increases anandamide levels, and increases the risk of obesity.
Georgia Balsevich, Gavin N Petrie, Daniel E Heinz, Arashdeep Singh, Robert J Aukema, Avery C Hunker, Haley A Vecchiarelli, Hiulan Yau, Martin Sticht, Roger J Thompson, Francis S Lee, Larry S Zweifel, Prasanth K Chelikani, Nils C Gassen, Matthew N Hill   +14 more
doaj   +1 more source

Assessment of the effects of CNR1, FAAH and MGLL gene variations on the synthetic cannabinoid use disorder

Türk Biyokimya Dergisi, 2023
Given that drug addiction occurs as a result of complex gene-environment interaction, a number of studies claimed that cannabinoid receptor 1 (CNR1), fatty acid amide hydrolase (FAAH), and monoacylglycerol lipase (MGLL) single nucleotide polymorphisms ...
Altun Beril, Cok Ismet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source

MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer

Cell Death and Disease, 2023
Glycerophospholipid signal and fatty acid metabolism are closely related to the occurrence and progression of tumours, and metabolic reprogramming caused by hydrolytic enzymes plays an important role in gastric cancer (GC).
Qian Yang, Shan Kong, Jiajia Yu, Yanhua Xu, Mei Tao, Shuo Ma, Chenxue Tang, Xianjuan Shen, Zhiyuan Tang, Shaoqing Ju   +9 more
doaj   +1 more source

Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study

Translational Psychiatry, 2021
Antisocial personality disorder (ASPD) imposes a high societal burden given the repetitive reactive aggression that affected individuals perpetrate. Since the brain endocannabinoid system (ECS) has been implicated in ASPD and aggressive behavior, we ...
Nathan J. Kolla, Isabelle Boileau, Karolina Karas, Jeremy J. Watts, Pablo Rusjan, Sylvain Houle, Romina Mizrahi   +6 more
doaj   +1 more source