Results 1 to 10 of about 9,726 (170)

Two legume fatty acid amide hydrolase isoforms with distinct preferences for microbial- and plant-derived acylamides

Scientific Reports, 2023
Fatty acid amide hydrolase (FAAH) is a widely conserved amidase in eukaryotes, perhaps best known for inactivating N-acylethanolamine lipid mediators. However, FAAH enzymes hydrolyze a wide range of acylamide substrates.
Omar Arias-Gaguancela, Emily Herrell, Mina Aziz, Kent D. Chapman   +3 more
doaj   +1 more source

Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4.

PLoS ONE, 2010
BackgroundRecent data have indicated that there may be a dysregulation of endocannabinoid metabolism in cancer. Here we have investigated the expression of the endocannabinoid metabolising enzyme fatty acid amide hydrolase (FAAH) in a well characterised ...
Lina Thors, Anders Bergh, Emma Persson, Peter Hammarsten, Pär Stattin, Lars Egevad, Torvald Granfors, Christopher J Fowler   +7 more
doaj   +1 more source

Effects of pharmacological inhibition of fatty acid amide hydrolase on corticosterone release: a systematic review of preclinical studies

Discover Mental Health
Psychiatric conditions are often linked to dysfunction of the Hypothalamic–Pituitary–Adrenal (HPA) axis. The Endocannabinoid System (ECS) plays a significant role in stress and anxiety and interacts with the HPA axis.
Christina F. Pereira, Isabelle Boileau, Stefan Kloiber   +2 more
doaj   +1 more source

Deleting adipose FXR exacerbates metabolic defects and induces endocannabinoid lipid, 2-oleoyl glycerol, in obesity

Journal of Lipid Research
The nutrient sensor farnesoid X receptor (FXR) transcriptionally regulates whole-body lipid and glucose homeostasis. Several studies examined targeting FXR as a modality to treat obesity with varying conflicting results, emphasizing the need to study ...
Weinan Zhou, Sarith R. Bandara, Kyungwon Ko, Oludemilade Akinrotimi, Diego Hernández-Saavedra, Emily Richter, Noah Brauer, Taylor J. Woodward, Heather B. Bradshaw, Cecilia Leal, Sayeepriyadarshini Anakk   +10 more
doaj   +1 more source

FAAH inhibition as a preventive treatment for migraine: A pre-clinical study

Neurobiology of Disease, 2020
Background: Fatty-acid amide hydrolase (FAAH) is an intracellular serine hydrolase that catalyzes the cleavage of endogenous fatty-acid amides, including the endocannabinoid anandamide (AEA).
Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Angelo Reggiani, Alessandra Misto, Daniele Piomelli, Cristina Tassorelli   +7 more
doaj   +1 more source

Evaluating Fatty Acid Amide Hydrolase as a Suitable Target for Sleep Promotion in a Transgenic TauP301S Mouse Model of Neurodegeneration

Pharmaceuticals
Sleep disruption is an expected component of aging and neurodegenerative conditions, including Alzheimer’s disease (AD). Sleep disruption has been demonstrated as a driver of AD pathology and cognitive decline.
Shenée C. Martin, Kathryn K. Joyce, Kathryn M. Harper, Samuel J. Harp, Todd J. Cohen, Sheryl S. Moy, Graham H. Diering   +6 more
doaj   +1 more source

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Fatty Acid Amide Hydrolase (FAAH) is a serine hydrolase that plays a key role in controlling endogenous levels of endocannabinoids. FAAH inhibition is considered a powerful approach to enhance the endocannabinoid signalling, and therefore it has been ...
Alessandro Deplano, Mariateresa Cipriano, Federica Moraca, Ettore Novellino, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis   +6 more
doaj   +1 more source

The anti-inflammatory and analgesic potential of the probiotic Streptococcus thermophilus via inhibition of endocannabinoid-degrading enzymes: a preliminary in vitro study [PDF]

Exploration of Immunology
Aim: The benefit of topical application of probiotics on pain and itching associated with skin disorders has become an increasingly intriguing topic in recent years.
Serena Altamura, Elona Dybeli, Francesca Lombardi, Paola Palumbo, Francesca Rosaria Augello, Skender Topi, Maria Grazia Cifone, Benedetta Cinque   +7 more
doaj   +1 more source

A preliminary investigation of tobacco co-use on endocannabinoid activity in people with cannabis use

Drug and Alcohol Dependence Reports
Tobacco is commonly co-used with cannabis. This is unfortunate because tobacco co-use exacerbates select clinical consequences associated with cannabis use.
Rachel A. Rabin, Joseph Farrugia, Ranjini Garani, Romina Mizrahi, Pablo Rusjan   +4 more
doaj   +1 more source

Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity

BMC Medical Genetics, 2010
Background The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH).
Rief Winfried, Scherag Susann, Vogel Carla IG, Grallert Harald, Scherag André, Greene Brandon H, Nguyen Trang T, Carrie Jophia, Wandolski Melanie, Brönner Günter, Müller Timo D, Wichmann Hans-Erich, Illig Thomas, Schäfer Helmut, Hebebrand Johannes, Hinney Anke   +15 more
doaj   +1 more source