Results 31 to 40 of about 8,951 (213)

Expression and Function of the Endocannabinoid Modulating Enzymes Fatty Acid Amide Hydrolase and N-Acylphosphatidylethanolamine-Specific Phospholipase D in Endometrial Carcinoma

Frontiers in Oncology, 2019
Background: The concentrations of three N-acylethanolamines (NAEs), anandamide (AEA), N-oleoylethanolamide (OEA), and N-palmitylethanolamide (PEA) are increased in the endometria of women with endometrial cancer (EC).
Thangesweran Ayakannu, Thangesweran Ayakannu, Anthony H. Taylor, Anthony H. Taylor, Monica Bari, Nicoletta Mastrangelo, Mauro Maccarrone, Justin C. Konje, Justin C. Konje, Justin C. Konje   +9 more
doaj   +1 more source

Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLD in vitro

Reproduction and Fertility, 2021
Objective: To determine if models of human 'receptive' and 'non-receptive endometrium' differ in their responses to nitric oxide (NO) supplementation by measuring the levels of the enzymes of the endocannabinoid system (ECS) (fatty acid amide hydrolase ...
Sarah E Melford, Anthony H Taylor, Justin C Konje   +2 more
doaj   +1 more source

An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase[S]

Journal of Lipid Research, 2011
Fatty acid amide hydrolase (FAAH) regulates amidated lipid transmitters, including the endocannabinoid anandamide and its N-acyl ethanolamine (NAE) congeners and transient receptor potential channel agonists N-acyl taurines (NATs).
Jonathan Z. Long, Melanie LaCava, Xin Jin, Benjamin F. Cravatt   +3 more
doaj   +1 more source

Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode.

PLoS ONE, 2015
BackgroundCombined fatty acid amide hydrolase (FAAH) and cyclooxygenase (COX) inhibition is a promising approach for pain-relief. The Flu-AM1 and Ibu-AM5 derivatives of flurbiprofen and ibuprofen retain similar COX-inhibitory properties and are more ...
Jessica Karlsson, Carmine M Morgillo, Alessandro Deplano, Giovanni Smaldone, Emilia Pedone, F Javier Luque, Mona Svensson, Ettore Novellino, Cenzo Congiu, Valentina Onnis, Bruno Catalanotti, Christopher J Fowler   +11 more
doaj   +1 more source

Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex

Neurobiology of Stress, 2021
The endocannabinoid system is involved in the regulation of the stress response, but the relative contribution of N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and their mechanisms have to be elucidated.
Francisco Javier Pavón, Ilham Y. Polis, David G. Stouffer, Benjamin F. Cravatt, Marisa Roberto, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Loren H. Parsons, Antonia Serrano   +8 more
doaj   +1 more source

The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD

NeuroImage: Clinical, 2022
Background: Posttraumatic Stress Disorder (PTSD) is commonly treated with exposure-based cognitive therapies that are based on the principles of fear acquisition and extinction learning. Elevations in one of the major endocannabinoids (anandamide) either
Kevin M. Crombie, Anthony A. Privratsky, Chloe M. Schomaker, Mickela Heilicher, Marisa C. Ross, Anneliis Sartin-Tarm, Kyrie Sellnow, Elisabeth B. Binder, G. Andrew James, Josh M. Cisler   +9 more
doaj   +1 more source

FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug.

, 2018
The discovery of extended catalytic versatilities is of great importance in both the chemistry and biotechnology fields. Fatty acid amide hydrolase (FAAH) belongs to the amidase signature superfamily and is a major endocannabinoid inactivating enzyme ...
Jose L. Martos (5818553), Ligresti, Alessia, Guida F, Sabatino Maione, Woodward DF, Carling RW, Cristoforo Silvestri (825109), Di Marzo V, David F. Woodward (2461168), Amoresano, Angela, Vitale RM, Marco Allarà (1343205), Allarà, Marco, Pietro Amodeo, Guida, Francesca, Anna Illiano, Vincenzo Di Marzo (203722), Woodward, David F, Allarà M, Cristoforo Silvestri, Marino G., Livio Luongo, Anna Illiano (5099513), Livio Luongo (490302), SILVESTRI, Ciro, Vitale, Rosa Maria, Alessia Ligresti, Jenny W. Wang (5818556), Vincenzo Di Marzo, Ligresti A, Amodeo P, Fabiana Piscitelli (203702), Angela Amoresano (363114), Marino, Gennaro, Jenny W. Wang, Luongo, Livio, Alessia Ligresti (250102), Robert W. Carling, Angela Amoresano, Sabatino Maione (140730), Silvestri, Cristoforo, Piscitelli, Fabiana, Wang, Jenny W, Jose L. Martos, Carling, Robert W, Rosa Maria Vitale, David F. Woodward, Amodeo, Pietro, Illiano A, Pietro Amodeo (458560), Gennaro Marino, Marco Allarà, Francesca Guida, Fabiana Piscitelli, Di Marzo, Vincenzo, Amoresano A, Rosa Maria Vitale (1867279), Maione, Sabatino, Luongo L, Robert W. Carling (2649880), Francesca Guida (490304), Wang JW, Piscitelli F, Martos, Jose L, Illiano, Anna, Maione S, Martos JL, Gennaro Marino (1505608)   +67 more
core   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent.

, 2014
Besides the suggested role of a putative endocannabinoid membrane transporter mediating the cellular uptake of the endocannabinoid anandamide (AEA), this process is intrinsically coupled to AEA degradation by the fatty acid amide hydrolase (FAAH ...
Soeberdt, Michael, Gertsch, Jürg, Abels, Christoph, Chicca, Andrea, Rau, Mark, Rihs, Sabine, Nicolussi, Simon   +6 more
core   +1 more source

The possible link between endocannabinoid system gene polymorphisms and overweight/obesity susceptibility in individuals living in the Marmara Region

Türk Biyokimya Dergisi
Obesity is a global health problem related to reduced life quality and shorter life expectancy. Given the fact that genetic factors play a role in obesity development, studies have suggested that polymorphisms of cannabinoid receptor 1 (CNR1 ...
Altun Beril, Cok İsmet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source