Results 31 to 40 of about 9,726 (170)

Radiometric Assay of FAAH Activity

, 2023
Fatty acid amide hydrolase (FAAH) is an intracellular enzyme responsible for the hydrolysis of endogenous anandamide (AEA), a reaction that terminates the biological effects of this lipid mediator.
Maccarrone, Mauro, Feole, Monica, Fava, Marina, Bari, Monica   +3 more
core   +1 more source

Inhibition of FAAH confers increased stem cell migration via PPARα

Journal of Lipid Research, 2015
Regenerative activity in tissues of mesenchymal origin depends on the migratory potential of mesenchymal stem cells (MSCs). The present study focused on inhibitors of the enzyme fatty acid amide hydrolase (FAAH), which catalyzes the degradation of ...
Yvonne Wollank, Robert Ramer, Igor Ivanov, Achim Salamon, Kirsten Peters, Burkhard Hinz   +5 more
doaj   +1 more source

Expression and Function of the Endocannabinoid Modulating Enzymes Fatty Acid Amide Hydrolase and N-Acylphosphatidylethanolamine-Specific Phospholipase D in Endometrial Carcinoma

Frontiers in Oncology, 2019
Background: The concentrations of three N-acylethanolamines (NAEs), anandamide (AEA), N-oleoylethanolamide (OEA), and N-palmitylethanolamide (PEA) are increased in the endometria of women with endometrial cancer (EC).
Thangesweran Ayakannu, Thangesweran Ayakannu, Anthony H. Taylor, Anthony H. Taylor, Monica Bari, Nicoletta Mastrangelo, Mauro Maccarrone, Justin C. Konje, Justin C. Konje, Justin C. Konje   +9 more
doaj   +1 more source

Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLD in vitro

Reproduction and Fertility, 2021
Objective: To determine if models of human 'receptive' and 'non-receptive endometrium' differ in their responses to nitric oxide (NO) supplementation by measuring the levels of the enzymes of the endocannabinoid system (ECS) (fatty acid amide hydrolase ...
Sarah E Melford, Anthony H Taylor, Justin C Konje   +2 more
doaj   +1 more source

Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.

PLoS ONE, 2014
BackgroundThe endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake ...
Emmelie Björklund, Anders Blomqvist, Joel Hedlin, Emma Persson, Christopher J Fowler   +4 more
doaj   +1 more source

The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD

NeuroImage: Clinical, 2022
Background: Posttraumatic Stress Disorder (PTSD) is commonly treated with exposure-based cognitive therapies that are based on the principles of fear acquisition and extinction learning. Elevations in one of the major endocannabinoids (anandamide) either
Kevin M. Crombie, Anthony A. Privratsky, Chloe M. Schomaker, Mickela Heilicher, Marisa C. Ross, Anneliis Sartin-Tarm, Kyrie Sellnow, Elisabeth B. Binder, G. Andrew James, Josh M. Cisler   +9 more
doaj   +1 more source

CRISPR interference at the FAAH-OUT genomic region reduces FAAH expression [PDF]

, 2019
FAAH-OUT encodes a putative long non-coding RNA which is located next to the FAAH gene on human chromosome 1. Recently an ~8 kb microdeletion, that removes upstream regulatory elements and the first 2 exons of FAAH-OUT, was reported in a pain insensitive
Cox, J, Mikaeili, H, Habib, A, Wood, J, Yeung, C, Okorokov, A   +5 more
core   +1 more source

Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode.

PLoS ONE, 2015
BackgroundCombined fatty acid amide hydrolase (FAAH) and cyclooxygenase (COX) inhibition is a promising approach for pain-relief. The Flu-AM1 and Ibu-AM5 derivatives of flurbiprofen and ibuprofen retain similar COX-inhibitory properties and are more ...
Jessica Karlsson, Carmine M Morgillo, Alessandro Deplano, Giovanni Smaldone, Emilia Pedone, F Javier Luque, Mona Svensson, Ettore Novellino, Cenzo Congiu, Valentina Onnis, Bruno Catalanotti, Christopher J Fowler   +11 more
doaj   +1 more source

An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase[S]

Journal of Lipid Research, 2011
Fatty acid amide hydrolase (FAAH) regulates amidated lipid transmitters, including the endocannabinoid anandamide and its N-acyl ethanolamine (NAE) congeners and transient receptor potential channel agonists N-acyl taurines (NATs).
Jonathan Z. Long, Melanie LaCava, Xin Jin, Benjamin F. Cravatt   +3 more
doaj   +1 more source

Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex

Neurobiology of Stress, 2021
The endocannabinoid system is involved in the regulation of the stress response, but the relative contribution of N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and their mechanisms have to be elucidated.
Francisco Javier Pavón, Ilham Y. Polis, David G. Stouffer, Benjamin F. Cravatt, Marisa Roberto, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Loren H. Parsons, Antonia Serrano   +8 more
doaj   +1 more source