Results 51 to 60 of about 8,951 (213)

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Author Correction: The endocannabinoid hydrolase FAAH is an allosteric enzyme [PDF]

Scientific Reports, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Enrico Dainese, Sergio Oddi, Monica Simonetti, Annalaura Sabatucci, Clotilde B. Angelucci, Alice Ballone, Beatrice Dufrusine, Filomena Fezza, Gianni De Fabritiis, Mauro Maccarrone   +9 more
openaire   +1 more source

Levels of FAAH protein and activity.

, 2013
a: Analysis of FAAH protein levels in PBMCs from LOAD and control (CT) subjects.
Daniela Galimberti (253047), Daniela Mari (312584), Bernardo Dell'Osso (319700), Elio Scarpini (253048), A. Carlo Altamura (319703), Claudio D'Addario (319693), Cristina Gussago (319698), Monica Bari (319701), Andrea Di Francesco (319695), Beatrice Arosio (319697), Mauro Maccarrone (276174)   +10 more
core   +1 more source

Identification of N-acylethanolamines in Dictyostelium discoideum and confirmation of their hydrolysis by fatty acid amide hydrolase[S]

Journal of Lipid Research, 2013
N-acylethanolamines (NAEs) are endogenous lipid-based signaling molecules best known for their role in the endocannabinoid system in mammals, but they are also known to play roles in signaling pathways in plants.
Alexander C. Hayes, Jacek Stupak, Jianjun Li, Andrew D. Cox   +3 more
doaj   +1 more source

Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders

Scientific Reports, 2022
Borderline personality disorder (BPD) and antisocial personality disorder (ASPD) are the two most frequently diagnosed and researched DSM-5 personality disorders, and both are characterized by high levels of trait neuroticism. Fatty acid amide hydrolase (
Nathan J. Kolla, Isabelle Boileau, R. Michael Bagby   +2 more
doaj   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Prostamide F2α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition

, 2014
Background and Purpose Prostamides are lipid mediators formed by COX-2-catalysed oxidation of the endocannabinoid anandamide and eliciting effects often opposed to those caused by anandamide.
LUONGO, Livio, Di Marzo, Vincenzo, Martos, Jose, Palmieri, Vittoria, Allarà, Marco, Ligresti, Alessia, GUIDA, Francesca, Wang, Jenny, Woodward, David   +8 more
core   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Anti-Inflammatory Effects by Pharmacological Inhibition or Knockdown of Fatty Acid Amide Hydrolase in BV2 Microglial Cells

Cells, 2019
Fatty acid amide hydrolase (FAAH) has been recognized as a therapeutic target for several neurological diseases because its inhibition can exert neuroprotective and anti-inflammatory effects by boosting the endogenous levels of N-acylethanolamines ...
Mikiei Tanaka, Kazuya Yagyu, Scott Sackett, Yumin Zhang   +3 more
doaj   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source