Results 51 to 60 of about 9,726 (170)
Design and pharmacological evaluation of Ibuprofen amides derivatives as dual FAAH/COX inhibitors [PDF]
, 2019 Fatty acid amide hydrolase (FAAH) is a serine hydrolase enzyme responsible of the hydrolytic degradation of N-acylethanolamine endocannabinoids, such as the Arachidonoylethanolamide (anandamide, AEA), which it has been shown to alleviate pain and ...
Fowler CJ +6 more
core
Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH
eLife, 2020 The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 ...
Joon T Kim +5 more
doaj +1 more source
Scientific Reports, 2022 Borderline personality disorder (BPD) and antisocial personality disorder (ASPD) are the two most frequently diagnosed and researched DSM-5 personality disorders, and both are characterized by high levels of trait neuroticism. Fatty acid amide hydrolase (
Nathan J. Kolla +2 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Journal of Lipid Research, 2013 N-acylethanolamines (NAEs) are endogenous lipid-based signaling molecules best known for their role in the endocannabinoid system in mammals, but they are also known to play roles in signaling pathways in plants.
Alexander C. Hayes +3 more
doaj +1 more source
Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways
British Journal of Pharmacology, EarlyView.Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck +1 more
wiley +1 more source
FAAH deficiency causes dyslipidemia.
, 2012 Fasted/re-fed plasma glucose and lipid profile for the FAAH−/− and wild-type mice. Plasma samples used were from [U-13C6] glucose (18 h fast) and [2-13C] glycerol (5 h re-feed) tracer infusion experiments.
Irwin J. Kurland (177409) +6 more
core +1 more source
Design of On-Target FAAH Inhibitors [PDF]
, 2005 In this issue of Chemistry & Biology, Alexander and Cravatt [1] propose a model for the binding of carbamate inhibitors to fatty acid amide hydrolase (FAAH), the enzyme that breaks down signaling lipids. Using competitive activity-based protein profiling
Deutsch, Dale G.
core +1 more source
British Journal of Pharmacology, EarlyView.The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli +6 more
wiley +1 more source
Levels of FAAH protein and activity.
, 2013 a: Analysis of FAAH protein levels in PBMCs from LOAD and control (CT) subjects.
Daniela Galimberti (253047) +10 more
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