Results 61 to 70 of about 8,951 (213)

Identification and recombinant expression of anandamide hydrolyzing enzyme from Dictyostelium discoideum

BMC Microbiology, 2012
Background Anandamide (Arachidonoyl ethanolamide) is a potent bioactive lipid studied extensively in humans, which regulates several neurobehavioral processes including pain, feeding and memory.
Neelamegan Dhamodharan, Schoenhofen Ian C, Richards James C, Cox Andrew D   +3 more
doaj   +1 more source

Oromucosal Administration of a Cannabidiol‐Enriched Cannabis sp. Extract for 2 Weeks Moderately Reduces Cold Hyperalgesia in Rats With Neuropathic Pain

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Chronic neuropathic pain (CNP) involves complex interactions between resident and peripheral immune cells, as well as modulation of the endocannabinoid system. Cannabis‐based products have emerged as promising therapeutic options, but their effects on immune cells remain unclear.
Raquel Maria Pereira Campos, Luciana Conde, Andrey Aguiar, Luzia Sampaio, Ricardo Augusto de Melo Reis, Pedro Moreno Pimentel‐Coelho   +5 more
wiley   +1 more source

So FAAH, so good, maybe [PDF]

Science-Business eXchange, 2008
UC Berkeley researchers have identified potent organophosphorus compounds that enhance cannabinoid receptor activity and could become a new class of pain therapy agents. Up for debate is which of the two enzymes targeted by the compounds is the better target, as well as the potential side effects of the compounds themselves.
openaire   +1 more source

The first evidence of an association between a polymorphism in the endocannabinoid-degrading enzyme FAAH (FAAH rs2295633) with attention deficit hyperactivity disorder

Genomics, 2020
Several single nucleotide polymorphisms (SNPs) of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the endocannabinoids, have been shown to be associated with many neuropsychiatric disorders. Here, FAAH rs2295633 was studied in ADHD and case-control healthy children. There was a significant difference in the allele frequency (P = .04) and
Ali, Ahmadalipour, Leila, Mehdizadeh Fanid, Narges, Zeinalzadeh, Maedeh, Alizadeh, Helaleh, Vaezi, Zahra, Hassanpour Aydinlou, Seyed Gholamreza, Noorazar   +6 more
openaire   +2 more sources

Biomarkers of endocannabinoid system activation in severe obesity.

PLoS ONE, 2010
BackgroundObesity is a worldwide epidemic, and severe obesity is a risk factor for many diseases, including diabetes, heart disease, stroke, and some cancers.
Jack C Sipe, T Michael Scott, Sarah Murray, Olivier Harismendy, Gabriel M Simon, Benjamin F Cravatt, Jill Waalen   +6 more
doaj   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Expression of FAAH and FLAT in mouse tissues.

, 2013
(A) RT-PCR analysis of FAAH and FLAT expression in mouse brain, spinal cord, and L3-L5 DRG. Transcripts representing full-length FAAH (~1740 base pair fragments) were found in all tissues examined.
Sherrye T. Glaser (479290), Matthew W. Elmes (479289), Dale G. Deutsch (295241), Martin Kaczocha (295232), KwanNok Leung (479288)   +4 more
core   +1 more source

FAAH genotype, CRFR1 genotype, and cortisol interact to predict anxiety in an aging, rural Hispanic population: A Project FRONTIER study

Neurobiology of Stress, 2019
The neurophysiological underpinnings involved in susceptibility to and maintenance of anxiety are not entirely known. However, two stress-responsive systems, the hypothalamic-pituitary-adrenal axis and the endocannabinoid system, may interact in anxiety.
Breanna N. Harris, Zachary P. Hohman, Callie M. Campbell, Kaleb S. King, Cody A. Tucker   +4 more
doaj   +1 more source

Cannabigerol Alleviates Obesity‐Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Graphical overview of the effects of the high‐fat, high‐sucrose (HFHS) diet regime and 2‐week cannabigerol (CBG) treatment on the intramuscular long‐chain fatty acids (LCFAs) trafficking and lipid metabolism, with subsequent implications for mitochondrial cardiolipin (CL) composition in the red gastrocnemius muscle.
Patrycja Bielawiec, Karolina Konstantynowicz‐Nowicka, Adrian Chabowski, Ewa Harasim‐Symbor   +3 more
wiley   +1 more source

Functional diversity drives leaf decomposition across rainfall–disturbance gradients, but phylogenetic effects vary

Ecosphere, Volume 17, Issue 6, June 2026.
Abstract Plant functional traits driving ecosystem functioning can have either similar or distinct evolutionary histories, meaning that both functional and phylogenetic diversity can jointly influence ecosystem dynamics. However, the relative importance of this relationship depends on the environmental context.
Rodrigo F. R. do Carmo, Pedro H. A. Sena, Felipe P. L. de Melo, Matheus Januario, Tamilie Carvalho, Fons van der Plas, Christian Wirth, Peter B. Reich, Thiago Gonçalves‐Souza   +8 more
wiley   +1 more source