Results 81 to 90 of about 9,726 (170)

Immunohistochemical staining for FAAH.

, 2013
Images on the left side of the panel represent the negative control (non-immune rabbit serum and images on the right are for FAAH. Images a and b are primordial follicle; c and d are primary follicles; e and f are secondary follicles; g and h are low ...
Mona R. El-Talatini (374359), Justin C. Konje (374363), Janine C. Elson (374361), Laurence Brown (43103), Allan C. Davidson (374362), Anthony H. Taylor (374360)   +5 more
core   +1 more source

Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise

Lipids in Health and Disease, 2011
Background Alterations of endocannabinoid system in adipose tissue play an important role in lipid regulation and metabolic dysfunction associated with obesity. The purpose of this study was to determine whether gene expression levels of cannabinoid type
Yang Rongze, Wang Xuewen, Disanzo Beth L, You Tongjian, Gong Dawei   +4 more
doaj   +1 more source

Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX ...
Alessandro Deplano, Jessica Karlsson, Mona Svensson, Federica Moraca, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis   +6 more
doaj   +1 more source

Association of FAAH-IR with prostate cancer outcome.

, 2013
Panel A. Receiver-operated characteristic (ROC) analyses for tumour epithelial (Epi) and blood vessel (BV) FAAH-IR. A 15 year cut-off was used for the patients who were not treated.
Lina Thors (362367), Christopher J. Fowler (124329), Peter Hammarsten (124310), Lars Egevad (124325), Emma Persson (362368), Torvald Granfors (124326), Pär Stattin (124323), Anders Bergh (175717)   +7 more
core   +1 more source

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

Journal of Lipid Research, 2004
We investigated the formation of PGF2α 1-ethanolamide, PGE2 1-ethanolamide, and PGD2 1-ethanolamide (prostamides F2α, E2, and D2, respectively) in liver, lung, kidney, and small intestine after a single intravenous bolus administration of 50 mg/kg of ...
Allan Weber, Jinsong Ni, Kah-Hiing John Ling, Andrew Acheampong, Diane D-S. Tang-Liu, Robert Burk, Benjamin F. Cravatt, David Woodward   +7 more
doaj   +1 more source

Fatty acid ethanolamides and FAAH inhibitor URB597.

, 2015
Fatty acid ethanolamides and FAAH inhibitor URB597.
Lisa Flammini (226054), Federica Vacondio (751463), Caterina Carmi (751467), Claudia Silva (751465), Riccardo Castelli (751466), Michele Bassi (751464), Laura Scalvini (751468), Silvia Rivara (751470), Alessio Lodola (180741), Valentina Vivo (751469), Marco Mor (180752), Elisabetta Barocelli (226056)   +11 more
core   +1 more source

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an ...
Naresh Sunduru, Mona Svensson, Mariateresa Cipriano, Sania Marwaha, C. David Andersson, Richard Svensson, Christopher J. Fowler, Mikael Elofsson   +7 more
doaj   +1 more source

Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs

Drug Design, Development and Therapy
Hongqing Zhao,1,2,* Yang Liu,1,2,* Na Cai,3 Xiaolin Liao,1,2 Lin Tang,2,4 Yuhong Wang1,2 1Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, People’s Republic of China; 2Hunan Key Laboratory of ...
Zhao H, Liu Y, Cai N, Liao X, Tang L, Wang Y   +5 more
doaj  

Ketoconazole inhibits the cellular uptake of anandamide via inhibition of FAAH at pharmacologically relevant concentrations.

PLoS ONE, 2014
BackgroundThe antifungal compound ketoconazole has, in addition to its ability to interfere with fungal ergosterol synthesis, effects upon other enzymes including human CYP3A4, CYP17, lipoxygenase and thromboxane synthetase. In the present study, we have
Emmelie Björklund, Therése N L Larsson, Stig O P Jacobsson, Christopher J Fowler   +3 more
doaj   +1 more source

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase

Molecules, 2016
Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties.
Yan Qiu, Yang Zhang, Yuhang Li, Jie Ren
doaj   +1 more source