Results 71 to 80 of about 9,726 (170)
The Roles of EETs in Neurological Disorders
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Rong Tang +6 more
wiley +1 more source
Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source
International Journal of Methods in Psychiatric Research, Volume 35, Issue 3, September 2026.ABSTRACT Objectives Anxiety disorders involve abnormal fear learning and exaggerated generalization, proposed as potential risk factors. However, it is unclear whether these processes reflect stable vulnerability markers or symptoms of psychopathology, as most research relies on cross‐sectional correlations and few longitudinal studies assess their ...
Jessica V. Reinhart +16 more
wiley +1 more source
, 2013 BACKGROUND: Anandamide and 2-arachidonoylglycerol are neuromodulatory lipids interacting with cannabinoid receptors, whose availability is regulated by the balance between "on demand" generation and enzymatic degradation (by FAAH/MAGL).
Muccioli, Giulio +2 more
core +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca +12 more
wiley +1 more source
Expression of FAAH and FLAT in mouse tissues.
, 2013 (A) RT-PCR analysis of FAAH and FLAT expression in mouse brain, spinal cord, and L3-L5 DRG. Transcripts representing full-length FAAH (~1740 base pair fragments) were found in all tissues examined.
Sherrye T. Glaser (479290) +4 more
core +1 more source
Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.Eryngium heterophyllum has 85 metabolites according to nontargeted UHPLC‐QTOF‐MS profiling, with flavonoids and phenylpropionic acids emerging as significantly related bioactive families. In silico compound–disease–target networks connect 31 metabolites to inflammation, diabetes, obesity, and cardiovascular disease associated with metabolic syndrome ...
Citlaly Gutiérrez‐Rodelo +5 more
wiley +1 more source
FAAH inhibitors in the limelight, but regrettably
, 2016 International audienceThis short review focuses on the recent drug development of FAAH inhibitors, as recent serious adverse events have been reported in a phase I study with a compound of this class.
Mallet, Christophe +2 more
core +1 more source
Expression of FAAH and FLAT in cell-lines.
, 2013 (A) Western blot of FAAH and FLAT expression in brain, HeLa cells transfected with FAAH (0.15 µg) or FLAT (1.5 µg), and in N18TG2 neuroblastoma and CCF-STTG1 astrocytoma cells. (B) Expression of FAAH and FLAT following transfection into HEK-293 cells. (C)
Sherrye T. Glaser (479290) +4 more
core +1 more source
, 2019 Nonsteroidal anti‐inflammatory drugs (NSAIDs) – such as ibuprofen and flurbiprofen – are non-selective COX inhibitors widely used to treat acute and chronic pain.
Fowler CJ +6 more
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