Results 71 to 80 of about 8,951 (213)

Two legume fatty acid amide hydrolase isoforms with distinct preferences for microbial- and plant-derived acylamides

Scientific Reports, 2023
Fatty acid amide hydrolase (FAAH) is a widely conserved amidase in eukaryotes, perhaps best known for inactivating N-acylethanolamine lipid mediators. However, FAAH enzymes hydrolyze a wide range of acylamide substrates.
Omar Arias-Gaguancela, Emily Herrell, Mina Aziz, Kent D. Chapman   +3 more
doaj   +1 more source

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, Volume 67, Issue 6, Page 3185-3198, June 2026.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source

Deleting adipose FXR exacerbates metabolic defects and induces endocannabinoid lipid, 2-oleoyl glycerol, in obesity

Journal of Lipid Research
The nutrient sensor farnesoid X receptor (FXR) transcriptionally regulates whole-body lipid and glucose homeostasis. Several studies examined targeting FXR as a modality to treat obesity with varying conflicting results, emphasizing the need to study ...
Weinan Zhou, Sarith R. Bandara, Kyungwon Ko, Oludemilade Akinrotimi, Diego Hernández-Saavedra, Emily Richter, Noah Brauer, Taylor J. Woodward, Heather B. Bradshaw, Cecilia Leal, Sayeepriyadarshini Anakk   +10 more
doaj   +1 more source

Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4.

PLoS ONE, 2010
BackgroundRecent data have indicated that there may be a dysregulation of endocannabinoid metabolism in cancer. Here we have investigated the expression of the endocannabinoid metabolising enzyme fatty acid amide hydrolase (FAAH) in a well characterised ...
Lina Thors, Anders Bergh, Emma Persson, Peter Hammarsten, Pär Stattin, Lars Egevad, Torvald Granfors, Christopher J Fowler   +7 more
doaj   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB(1) and FAAH-independent mechanisms

, 2013
BACKGROUND: Anandamide and 2-arachidonoylglycerol are neuromodulatory lipids interacting with cannabinoid receptors, whose availability is regulated by the balance between "on demand" generation and enzymatic degradation (by FAAH/MAGL).
Muccioli, Giulio, Bosier, Barbara, Lambert, Didier   +2 more
core   +1 more source

Evaluating Fatty Acid Amide Hydrolase as a Suitable Target for Sleep Promotion in a Transgenic TauP301S Mouse Model of Neurodegeneration

Pharmaceuticals
Sleep disruption is an expected component of aging and neurodegenerative conditions, including Alzheimer’s disease (AD). Sleep disruption has been demonstrated as a driver of AD pathology and cognitive decline.
Shenée C. Martin, Kathryn K. Joyce, Kathryn M. Harper, Samuel J. Harp, Todd J. Cohen, Sheryl S. Moy, Graham H. Diering   +6 more
doaj   +1 more source

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Fatty Acid Amide Hydrolase (FAAH) is a serine hydrolase that plays a key role in controlling endogenous levels of endocannabinoids. FAAH inhibition is considered a powerful approach to enhance the endocannabinoid signalling, and therefore it has been ...
Alessandro Deplano, Mariateresa Cipriano, Federica Moraca, Ettore Novellino, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis   +6 more
doaj   +1 more source

FAAH inhibition as a preventive treatment for migraine: A pre-clinical study

Neurobiology of Disease, 2020
Background: Fatty-acid amide hydrolase (FAAH) is an intracellular serine hydrolase that catalyzes the cleavage of endogenous fatty-acid amides, including the endocannabinoid anandamide (AEA).
Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Angelo Reggiani, Alessandra Misto, Daniele Piomelli, Cristina Tassorelli   +7 more
doaj   +1 more source

Prospective, Double‐Blind, Vehicle‐Controlled Assessment of Topical Bakuchiol on Photoaging in a Chinese Population

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Aging skin is a universal complaint among diverse patient populations. It encompasses physiologic changes to the skin, such as skin laxity, dyspigmentation, fine lines, and wrinkles. However, different populations may show different signs of aged skin.
Zill‐e‐human Khan, Ratan K. Chaudhuri, Ajay Dulai, Anurag Tarmaster, Libing Pan, Raja K. Sivamani   +5 more
wiley   +1 more source