Results 91 to 100 of about 8,951 (213)

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

Journal of Lipid Research, 2004
We investigated the formation of PGF2α 1-ethanolamide, PGE2 1-ethanolamide, and PGD2 1-ethanolamide (prostamides F2α, E2, and D2, respectively) in liver, lung, kidney, and small intestine after a single intravenous bolus administration of 50 mg/kg of ...
Allan Weber, Jinsong Ni, Kah-Hiing John Ling, Andrew Acheampong, Diane D-S. Tang-Liu, Robert Burk, Benjamin F. Cravatt, David Woodward   +7 more
doaj   +1 more source

Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX ...
Alessandro Deplano, Jessica Karlsson, Mona Svensson, Federica Moraca, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis   +6 more
doaj   +1 more source

Arylboronic acids as dual-action FAAH and TRPV1 ligands

, 2016
A series of 31 arylboronic acids designed on the basis of the pharmacophore model for a variety of TRPV1 antagonists was prepared and tested on FAAH and TRPV1 channel.
Di Marzo, Vincenzo, Schiano Moriello, Aniello, MORERA, ENRICO, Luciano De Petrocellis, Enrico Morera, Vincenzo Di Marzo, Marianna Nalli, NALLI, Marianna, Allarà, Marco, De Petrocellis, Luciano, Ludovica Monti, Giorgio Ortar, MONTI, LUDOVICA, Aniello Schiano Moriello, ORTAR, Giorgio, Marco Allarà   +15 more
core   +1 more source

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity [PDF]

, 2019
The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally painful orthopaedic hand surgery ...
Bennett, David L.H., Houlden, Henry H., Gossage, Samuel J., Bras, Jose T., Ramirez, Juan D., Okorokov, Andrei L., Cox, James J., Srivastava, Devjit, Habib, Abdella M., Lee, Man-Cheung, Hill, Beta Matthew Nicholas, Li, Shengnan, Drimmelen, Marie van   +12 more
core   +3 more sources

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an ...
Naresh Sunduru, Mona Svensson, Mariateresa Cipriano, Sania Marwaha, C. David Andersson, Richard Svensson, Christopher J. Fowler, Mikael Elofsson   +7 more
doaj   +1 more source

FAAH deficiency promotes energy storage and enhances the motivation for food [PDF]

, 2010
RationaleFatty acid amide hydrolase (FAAH) is the main degrading enzyme of the fatty acid ethanolamides anandamide (AEA) and oleoylethanolamide (OEA), which have opposite effects on food intake and energy balance.
Oveisi, F, D Piomelli, Piomelli, D, J Lockney, C Touriño, Touriño, C, Maldonado, R, Lockney, J, F Oveisi, R Maldonado   +9 more
core   +1 more source

Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise

Lipids in Health and Disease, 2011
Background Alterations of endocannabinoid system in adipose tissue play an important role in lipid regulation and metabolic dysfunction associated with obesity. The purpose of this study was to determine whether gene expression levels of cannabinoid type
Yang Rongze, Wang Xuewen, Disanzo Beth L, You Tongjian, Gong Dawei   +4 more
doaj   +1 more source

IL-4 affects FAAH activity in prostate cancer cells.

, 2013
Panel A, IL-4 receptor immunoreactivity in a prostate tumour tissue sample (Gleason score 8). The line at the bottom left of the picture represents 100 µm.
Lina Thors (362367), Christopher J. Fowler (124329), Peter Hammarsten (124310), Lars Egevad (124325), Emma Persson (362368), Torvald Granfors (124326), Pär Stattin (124323), Anders Bergh (175717)   +7 more
core   +1 more source

Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs

Drug Design, Development and Therapy
Hongqing Zhao,1,2,* Yang Liu,1,2,* Na Cai,3 Xiaolin Liao,1,2 Lin Tang,2,4 Yuhong Wang1,2 1Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, People’s Republic of China; 2Hunan Key Laboratory of ...
Zhao H, Liu Y, Cai N, Liao X, Tang L, Wang Y   +5 more
doaj  

Investigating Endocannabinoid Metabolism in Alcohol Use Disorder: a focus on fatty acid amide hydrolase (FAAH)

, 2022
The endocannabinoid enzyme, fatty acid amide hydrolase (FAAH), has been proposed as a therapeutic target for Alcohol Use Disorder (AUD) and psychiatric illnesses. Studies suggest that FAAH regulates alcohol intake/preference, and its impairment increases
Best, Laura M
core