Results 101 to 110 of about 9,726 (170)

FAAH deficiency affects fuel storage.

, 2012
a. Fed triglycerides and glycogen of liver and skeletal muscle. Upper panel shows thin layer chromatography (TLC) for hepatic and intra-muscular triglycerides with corresponding densitometry.
Irwin J. Kurland (177409), Kirsten Hartil (177391), James E. Bruce (177406), Sherrye Glaser (177394), Bhavapriya Vaitheesvaran (177385), Li Yang (6520), Stephen Yazulla (177399)   +6 more
core   +1 more source

Effect of DGPP 10 µM on FAAH activity and expression.

, 2013
Uterine strips from rats pregnant on day 5 of gestation were incubated for 6 h with DGPP 10 µM. FAAH activity was determine by radioconversion and FAAH mRNA and protein expression was analyzed by RT-PCR and Western Blot respectively.
Silvina Perez Martinez (304948), Elsa Zotta (304950), Maximiliano Cella (304946), Ana M. Franchi (284968), Micaela S. Sordelli (304944), Jimena S. Beltrame (304945), María Gracia Gervasi (304947), Juliana Burdet (304949), María Laura Ribeiro (304951)   +8 more
core   +1 more source

Expression of Fatty Acid Amide Hydrolase (FAAH) in Human, Mouse, and Rat Urinary Bladder and Effects of FAAH Inhibition on Bladder Function in Awake Rats.

, 2012
BACKGROUND: Cannabinoid receptor (CB)-mediated functions may be involved in the regulation of bladder function, but information on endocannabinoid signals during micturition is scarce.
Arianna Bettiga, Bettiga, A.,, Stief, C.,, Petter Hedlund, Christian Gratzke, Benigni, Fabio, Christian Stief, Colciago, Giorgia, Francesco Montorsi, Rigatti, Patrizio, Stief, Christian, Benigni, F.,, Hedlund, Petter,, Fabio Benigni, Strittmatter, Frank, Gratzke, C.,, Montorsi, Francesco, Gandaglia, Giorgio, Montorsi, F.,, Rigatti, P.,, Colciago, G.,, Hedlund, Petter, Frank Strittmatter, Giorgia Colciago, Gratzke, Christian, Strittmatter, F.,, Gandaglia, G.,, Bettiga, Arianna, Giorgio Gandaglia, Patrizio Rigatti   +29 more
core   +1 more source

Discovery of FAAH inhibitors by rational drug design [PDF]

, 2011
脂肪酰胺水解酶(FAAH)是调控内源性脂肪酰胺信使脂质分子代谢的主要酶。FAAH活性抑制即可以使体内内源性脂肪酰胺水平升高，达到镇痛、抗炎、协调运动机能的目的，过去十年间，具有FAAH抑制活性的大量化合物也得到报道，但是到目前为止，还没有成功上市的FAAH抑制剂，关键的原因就在于其选择性与抑制效率无法兼顾。本文在此基础上，展开了如下工作： 一、利用药效团构建软件DiscoveryStudio2.1构建定性的CommonFeature药效团和定量的3DQSAR药效团模型 ...
赵东升
core  

Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields

, 2020
Fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) are the main enzymes responsible for the hydrolysis of endogenous cannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.
Maija ; Saario, Ari M P, Poso S M, M J Myllymaki, Antti ; Koskinen, Lahtela-Kakkonen, user. Myllymaki Mikko J ; Kasnanen, A O Kataja, Antti O ; Lahtela-Kakkonen, Heikki ; Kataja, Susanna M ; Poso, M Saario, A Koskinen, H Kasnanen, A M P   +14 more
core  

Photoreceptor preservation by FAAH inhibition in a murine model of retinitis pigmentosa. [PDF]

Mol Neurobiol
Magalhães CF, de Freitas Azevedo-Repossi R, de Almeida-Pereira L, Crisóstomo MC, Pereira MR, da Costa Calaza K, Petrs-Silva H, Fragel-Madeira L.   +7 more
europepmc   +1 more source

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity

, 2019
The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally painful orthopaedic hand surgery ...
Lee, M-C, Houlden, H, Bennett, D, Cox, J, Morena, M, Ramirez, J, Hill, M, Habib, A, Srivastava, D, van Drimmelen, M, Gossage, S, Bras, J, Li, S, Okorokov, A   +13 more
core  

Enhancing anandamide signalling through fatty acid amide hydrolase inhibition: An update on the pharmacological strategy for treating psychiatric disorders. [PDF]

Transl Psychiatry
Couttas TA, Hoffmann AE, Jieu B, Golla FR, Shepherd CE, Leweke FM, Rohleder C.   +6 more
europepmc   +1 more source

FAAH rs324420 Polymorphism in People With Opioid and Methamphetamine Use Disorders: Psychological Associations. [PDF]

Brain Behav
Erekli-Arat Ö, Tepe M, Özkan-Kotiloğlu S, Danışman M, Kaya-Akyüzlü D.   +4 more
europepmc   +1 more source

Distribution and subacute modulation of endocannabinoid metabolizing enzymes in the trigeminal complex and midbrain in a pre-clinical model of post-traumatic headache. [PDF]

J Headache Pain
Nagarajan G, Zhang Y.
europepmc   +1 more source