Results 101 to 110 of about 8,951 (213)
FAAH immunoreactivity in formalin-foxed prostate cancer samples.
, 2013 Panel A. Example of FAAH-IR in a core of non-malignant prostate tissue obtained at transurethral resection from a 75 year old patient. The asterisks indicate blood vessels, and the # symbol indicates FAAH positive cells, presumably infiltrating ...
Lina Thors (362367) +7 more
core +1 more source
, 2010 FAAH inhibitors: This study identifies a new class of enol carbamates as potent reversibleinhibitors of fatty acid amide hydrolase (FAAH), endowed with high selectivity towards this target over other components of endocannabinoid ...
Walter Cabri +27 more
core +2 more sources
PLoS ONE, 2014 BackgroundThe antifungal compound ketoconazole has, in addition to its ability to interfere with fungal ergosterol synthesis, effects upon other enzymes including human CYP3A4, CYP17, lipoxygenase and thromboxane synthetase. In the present study, we have
Emmelie Björklund +3 more
doaj +1 more source
Inhibition of Fatty Acid Amide Hydrolase (FAAH) by Macamides
The FASEB Journal, 2018 Purpose Pentane extract of the Peruvian plant Lepidium meyenii (Maca) has been demonstrated to possess neuroprotective activity in previous studies. This extract contains several macamides that might act on the endocannabinoid system.
M. Alasmari +4 more
openaire +2 more sources
Inhibiting Fatty Acid Amide Hydrolase (FAAH) Induces Apoptosis in Breast Cancer Cells [PDF]
, 2020 Background: Breast cancer is a highly heterogeneous, aggressive disease that has poor prognosis. Current treatment is present, but research on a therapeutic alternative is ongoing.
Tripathy, Mallika +1 more
core
HeliyonLipid metabolism in cancer refers to the alterations in how cancer cells process and utilize lipids, a type of fat molecule. It was investigated how lipid metabolism relates to osteosarcoma.
Yanbin Shi +4 more
doaj +1 more source
Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase
Molecules, 2016 Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties.
Yan Qiu, Yang Zhang, Yuhang Li, Jie Ren
doaj +1 more source
Genetic and epigenetic regulation of faah gene.
, 2013 a: Levels of FAAH mRNA in PBMCs from LOAD patients (n = 13) and controls (n = 12); b: Amount of methylated DNA at faah gene in controls (n = 33 ) and LOAD subjects (n = 33); c: Correlation between faah gene expression and % change of DNA methylation in ...
Daniela Galimberti (253047) +10 more
core +1 more source
Switching cannabinoid response from CB2 agonists to FAAH inhibitors
, 2014 International audienceA series of 3-carboxamido-5-aryl-isoxazoles designed as CB2 agonists were evaluated as FAAH inhibitors. The pharmacological results led to identify structure-activity relationships enabling to switch cannabinoid response from CB2 ...
Andrzejak, Virginie +9 more
core +1 more source
Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease.
PLoS ONE, 2012 ObjectiveAlzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the ...
Claudio D'Addario +10 more
doaj +1 more source