Results 41 to 50 of about 8,951 (213)
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase
Molecular Pain, 2016 Fatty-acid amide hydrolase (FAAH) is the major enzyme responsible for degradation of anandamide, an endocannabinoid. Pharmacological inhibition or genetic deletion of FAAH (FAAH KO) produces antinociception in preclinical pain models that is largely ...
Lawrence M Carey BA, MS +6 more
doaj +1 more source
Plant Direct, 2022 Fatty acid amide hydrolase (FAAH) is a conserved amidase that is known to modulate the levels of endogenous N‐acylethanolamines (NAEs) in both plants and animals.
Omar Arias‐Gaguancela +3 more
doaj +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Design and pharmacological evaluation of Ibuprofen amides derivatives as dual FAAH/COX inhibitors [PDF]
, 2019 Fatty acid amide hydrolase (FAAH) is a serine hydrolase enzyme responsible of the hydrolytic degradation of N-acylethanolamine endocannabinoids, such as the Arachidonoylethanolamide (anandamide, AEA), which it has been shown to alleviate pain and ...
Fowler CJ +6 more
core
Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders
Clinical, Cosmetic and Investigational Dermatology, 2020 Sudhir M Baswan,1,* Allison E Klosner,2,* Kelly Glynn,1 Arun Rajgopal,1 Kausar Malik,1 Sunghan Yim,1 Nathan Stern1 1Innovation and Science, Amway Corporation, Ada, MI, 49355, USA; 2Innovation and Science, Nutrilite Health Institute, Amway Corporation ...
Baswan SM +6 more
doaj
Crystals, 2019 Fatty acid amide hydrolase (FAAH) is a well-characterized member of the amidase signature (AS) family of serine hydrolases. The membrane-bound FAAH protein is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and ...
Cho-Ah Min +6 more
doaj +1 more source
Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH
eLife, 2020 The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 ...
Joon T Kim +5 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
FAAH deficiency causes dyslipidemia.
, 2012 Fasted/re-fed plasma glucose and lipid profile for the FAAH−/− and wild-type mice. Plasma samples used were from [U-13C6] glucose (18 h fast) and [2-13C] glycerol (5 h re-feed) tracer infusion experiments.
Irwin J. Kurland (177409) +6 more
core +1 more source
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme
, 2021 The fatty acid amide hydrolase (FAAH) executes a unique role in terminating endocannabinoid signaling, and is the major regulator of anadamide catabolism in vivo.
Butini S., Campiani G., Gemma S.
core +1 more source