Results 21 to 30 of about 9,726 (170)

Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study

Translational Psychiatry, 2021
Antisocial personality disorder (ASPD) imposes a high societal burden given the repetitive reactive aggression that affected individuals perpetrate. Since the brain endocannabinoid system (ECS) has been implicated in ASPD and aggressive behavior, we ...
Nathan J. Kolla, Isabelle Boileau, Karolina Karas, Jeremy J. Watts, Pablo Rusjan, Sylvain Houle, Romina Mizrahi   +6 more
doaj   +1 more source

Molecular basis of FAAH-OUT-associated human pain insensitivity [PDF]

, 2023
Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain insensitivity disorders.
Zuberi, Sana, Wood, John N, Mikaeili, Hajar, Athanasiou-Fragkouli, Alkyoni, Houlden, Henry, Yeung, Charlix Wai-Lok, Habib, Abdella M, Santana-Varela, Sonia, Okorokov, Andrei L, Panteleeva, Kseniia, Luiz, Ana P, Cox, James J   +11 more
core   +1 more source

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

Journal of Lipid Research, 2005
N-Arachidonylethanolamine (AEA) accumulates during brain injury and postmortem. Because fatty acid amide hydrolase (FAAH) regulates brain AEA content, the purpose of this study was to determine its role in the postmortal accumulation of AEA using FAAH ...
Sachin Patel, Erica J. Carrier, W-S. Vanessa Ho, David J. Rademacher, Sonya Cunningham, D. Sudarshan Reddy, J.R. Falck, Benjamin F. Cravatt, Cecilia J. Hillard   +8 more
doaj   +1 more source

Fluorimetric Assay of FAAH Activity

, 2023
: Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the degradation of anandamide (N-arachidonoylethanolamine, AEA) to arachidonic acid (AA) and ethanolamine.
Maccarrone, Mauro, Angelucci, Clotilde B, Giacominelli-Stuffler, Roberto   +2 more
core   +1 more source

Peripheral effects of FAAH deficiency on fuel and energy homeostasis: role of dysregulated lysine acetylation.

PLoS ONE, 2012
BackgroundFAAH (fatty acid amide hydrolase), primarily expressed in the liver, hydrolyzes the endocannabinoids fatty acid ethanolamides (FAA). Human FAAH gene mutations are associated with increased body weight and obesity.
Bhavapriya Vaitheesvaran, Li Yang, Kirsten Hartil, Sherrye Glaser, Stephen Yazulla, James E Bruce, Irwin J Kurland   +6 more
doaj   +1 more source

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro

BMC Pharmacology and Toxicology, 2022
Background Pain relief remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far have low to moderate efficiencies with significant untoward side effects. FAAH-1 has been proposed as a
Julius T. Dongdem, Gideon K. Helegbe, Kwame Opare-Asamoah, Cletus A. Wezena, Augustine Ocloo   +4 more
doaj   +1 more source

Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review

Pharmaceuticals, 2021
The endocannabinoid system (ECS) plays an integral role in maintaining metabolic homeostasis and may affect hunger, caloric intake, and nutrient absorption.
Justin Matheson, Xin Ming Matthew Zhou, Zoe Bourgault, Bernard Le Foll   +3 more
doaj   +1 more source

Might modulation of the endocannabinoid system provide a potential dual therapeutic strategy for osteoporosis and depression? [PDF]

Gen Psychiatr
General Psychiatry, Volume 39, Issue 4, August 2026.
Wei P, Zhao P, Gu Z, Yang M, Karasik D, Cheung CL, Zheng H.   +6 more
europepmc   +2 more sources

Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent. [PDF]

, 2014
Besides the suggested role of a putative endocannabinoid membrane transporter mediating the cellular uptake of the endocannabinoid anandamide (AEA), this process is intrinsically coupled to AEA degradation by the fatty acid amide hydrolase (FAAH ...
Soeberdt, Michael, Gertsch, Jürg, Abels, Christoph, Chicca, Andrea, Rau, Mark, Rihs, Sabine, Nicolussi, Simon   +6 more
core   +1 more source

The endocannabinoid hydrolase FAAH is an allosteric enzyme [PDF]

, 2020
Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that in vivo controls content and biological activity of N-arachidonoylethanolamine (AEA) and other relevant bioactive lipids termed endocannabinoids.
Dainese E., Clotilde B. Angelucci, Oddi S., Simonetti, Monica, Beatrice Dufrusine, Ballone A., Angelucci, Clotilde B., Dainese, Enrico, Fezza, Filomena, Sabatucci A., Simonetti M., Filomena Fezza, Fezza F., Enrico Dainese, Sergio Oddi, Angelucci C. B., Mauro Maccarrone, Monica Simonetti, Annalaura Sabatucci, Ballone, Alice, Oddi, Sergio, Maccarrone, Mauro, Alice Ballone, Dufrusine B., De Fabritiis, Gianni, Maccarrone M., De Fabritiis G., Sabatucci, Annalaura, Dufrusine, Beatrice, Gianni De Fabritiis   +29 more
core   +1 more source