Results 21 to 30 of about 8,951 (213)

FAAH selectively influences placebo effects [PDF]

Molecular Psychiatry, 2013
Endogenous opioid and cannabinoid systems are thought to act synergistically regulating antinociceptive and reward mechanisms. To further understand the human implications of the interaction between these two systems, we investigated the role of the common, functional missense variant Pro129Thr of the gene coding fatty acid amide hydrolase (FAAH), the ...
Peciña, M., Martínez-Jauand, M., Hodgkinson, C., Stohler, C.S., Goldman, D., Zubieta, J.K.   +5 more
openaire   +2 more sources

A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity [PDF]

Psychopharmacology, 2012
The endocannabinoid (eCB) system is implicated in several psychiatric disorders. Investigating emotional-motivational dysfunctions as underlying mechanisms, a study in humans revealed that in the C385A polymorphism of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the eCB anandamide (AEA), A carriers, who are characterized by increased ...
Conzelmann, Annette, Reif, Andreas, Jacob, Christian, Weyers, Peter, Lesch, Klaus-Peter, Lutz, Beat, Pauli, Paul   +6 more
openaire   +5 more sources

Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review

Pharmaceuticals, 2021
The endocannabinoid system (ECS) plays an integral role in maintaining metabolic homeostasis and may affect hunger, caloric intake, and nutrient absorption.
Justin Matheson, Xin Ming Matthew Zhou, Zoe Bourgault, Bernard Le Foll   +3 more
doaj   +1 more source

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

Journal of Lipid Research, 2005
N-Arachidonylethanolamine (AEA) accumulates during brain injury and postmortem. Because fatty acid amide hydrolase (FAAH) regulates brain AEA content, the purpose of this study was to determine its role in the postmortal accumulation of AEA using FAAH ...
Sachin Patel, Erica J. Carrier, W-S. Vanessa Ho, David J. Rademacher, Sonya Cunningham, D. Sudarshan Reddy, J.R. Falck, Benjamin F. Cravatt, Cecilia J. Hillard   +8 more
doaj   +1 more source

Peripheral effects of FAAH deficiency on fuel and energy homeostasis: role of dysregulated lysine acetylation.

PLoS ONE, 2012
BackgroundFAAH (fatty acid amide hydrolase), primarily expressed in the liver, hydrolyzes the endocannabinoids fatty acid ethanolamides (FAA). Human FAAH gene mutations are associated with increased body weight and obesity.
Bhavapriya Vaitheesvaran, Li Yang, Kirsten Hartil, Sherrye Glaser, Stephen Yazulla, James E Bruce, Irwin J Kurland   +6 more
doaj   +1 more source

Preclinical Characterization of the FAAH Inhibitor JNJ-42165279 [PDF]

ACS Medicinal Chemistry Letters, 2015
The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors.
John M, Keith, William M, Jones, Mark, Tichenor, Jing, Liu, Mark, Seierstad, James A, Palmer, Michael, Webb, Mark, Karbarz, Brian P, Scott, Sandy J, Wilson, Lin, Luo, Michelle L, Wennerholm, Leon, Chang, Michele, Rizzolio, Raymond, Rynberg, Sandra R, Chaplan, J Guy, Breitenbucher   +16 more
openaire   +2 more sources

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro

BMC Pharmacology and Toxicology, 2022
Background Pain relief remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far have low to moderate efficiencies with significant untoward side effects. FAAH-1 has been proposed as a
Julius T. Dongdem, Gideon K. Helegbe, Kwame Opare-Asamoah, Cletus A. Wezena, Augustine Ocloo   +4 more
doaj   +1 more source

Inhibition of FAAH confers increased stem cell migration via PPARα

Journal of Lipid Research, 2015
Regenerative activity in tissues of mesenchymal origin depends on the migratory potential of mesenchymal stem cells (MSCs). The present study focused on inhibitors of the enzyme fatty acid amide hydrolase (FAAH), which catalyzes the degradation of ...
Yvonne Wollank, Robert Ramer, Igor Ivanov, Achim Salamon, Kirsten Peters, Burkhard Hinz   +5 more
doaj   +1 more source

Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.

PLoS ONE, 2014
BackgroundThe endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake ...
Emmelie Björklund, Anders Blomqvist, Joel Hedlin, Emma Persson, Christopher J Fowler   +4 more
doaj   +1 more source

Molecular basis of FAAH-OUT-associated human pain insensitivity [PDF]

, 2023
Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain insensitivity disorders.
Zuberi, Sana, Wood, John N, Mikaeili, Hajar, Athanasiou-Fragkouli, Alkyoni, Houlden, Henry, Yeung, Charlix Wai-Lok, Habib, Abdella M, Santana-Varela, Sonia, Okorokov, Andrei L, Panteleeva, Kseniia, Luiz, Ana P, Cox, James J   +11 more
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