Results 11 to 20 of about 9,726 (170)

A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice

eLife, 2023
Fatty acid amide hydrolase (FAAH) degrades the endocannabinoid anandamide. A polymorphism in FAAH (FAAH C385A) reduces FAAH expression, increases anandamide levels, and increases the risk of obesity.
Georgia Balsevich, Gavin N Petrie, Daniel E Heinz, Arashdeep Singh, Robert J Aukema, Avery C Hunker, Haley A Vecchiarelli, Hiulan Yau, Martin Sticht, Roger J Thompson, Francis S Lee, Larry S Zweifel, Prasanth K Chelikani, Nils C Gassen, Matthew N Hill   +14 more
doaj   +2 more sources

Fatty Acid Amide Hydrolase Signaling and Ovarian Disorders: From Molecular Mechanism to Clinical Significance [PDF]

Molecules
Fatty acid amide hydrolase (FAAH) is a central component of the endocannabinoid system (ECS), where it primarily regulates intracellular levels of anandamide (AEA) through enzymatic hydrolysis.
Qinghe Lin, Zhenghong Zhang, Defan Wang, Fan Wang, Zhengchao Wang   +4 more
doaj   +2 more sources

Identification of quinolinyl-containing dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors with moderate potency towards acetylcholinesterase [PDF]

Results in Chemistry
Using a polypharmacological approach, we designed two different quinolinyl libraries by merging the pharmacophores of three targeted enzymes, fatty acid amide hydrolase (FAAH), soluble epoxide hydrolase (sEH), and acetylcholinesterase (AChE).
Michael Gonzalez, Ryan West, Amanda Tsang, Olivia Ocampo, Paula K. Hudson, Stevan Pecic   +5 more
doaj   +2 more sources

Role of FAAH-like anandamide transporter in anandamide inactivation. [PDF]

PLoS ONE, 2013
The endocannabinoid system modulates numerous physiological processes including nociception and reproduction. Anandamide (AEA) is an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydrolase
Kwannok Leung, Matthew W Elmes, Sherrye T Glaser, Dale G Deutsch, Martin Kaczocha   +4 more
doaj   +3 more sources

N-Arachidonoyl-phosphatidylethanolamide phospholipase D activation by muscarinic receptors. [PDF]

J Physiol
Abstract figure legend Activating muscarinic M3 receptors activates Gq‐pathway signalling, including the activation of phospholipase C (PLC) and release of calcium from internal stores as shown in the upper panel. It remains unclear whether the calcium acts on N‐arachidonoyl‐phosphatidylethanolamide phospholipase D (NAPE‐PLD) itself or upstream at N ...
Murataeva N, Schmitt C, Hyman E, Wager-Miller J, Matthews I, Cai R, Cai S, Li Y, Mackie K, Straiker A.   +9 more
europepmc   +2 more sources

Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha-Fatty-Acid Amide Hydrolase 1 Signaling Pathway. [PDF]

MedComm (2020)
1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Novoa E, Cabaleiro A, López-Picallo B, Lima NDS, Riobello C, Pena C, Iglesias-Moure J, Senra A, Martínez-Chantar ML, Fernandez-Iglesias A, Gracia-Sancho J, Bravo S, Dieguez C, Varela-Rey M, Prevot V, Schwaninger M, López M, Nogueiras R.   +17 more
europepmc   +2 more sources

Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1^G93A Mice. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Dalle S, Vanderbeke K, Burg T, Schouten M, Lauriks W, Hersmus N, Van Den Bosch L, Koppo K.   +7 more
europepmc   +2 more sources

Assessment of the effects of CNR1, FAAH and MGLL gene variations on the synthetic cannabinoid use disorder

Türk Biyokimya Dergisi, 2023
Given that drug addiction occurs as a result of complex gene-environment interaction, a number of studies claimed that cannabinoid receptor 1 (CNR1), fatty acid amide hydrolase (FAAH), and monoacylglycerol lipase (MGLL) single nucleotide polymorphisms ...
Altun Beril, Cok Ismet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source

FAAH-4 is involved in cholesterol mobilization by 2-AG.

, 2022
(A) Wild type and faah-4 animals grown for two generations in the absence of cholesterol at 20°C arrest as L2*. Feeding with 2-AG (50 μg/ml) increases the formation of adults in faah-4 animals compared with N2 animals.
Cecilia Vranych (14076749), Bruno Hernandez-Cravero (14076740), Sofia Gallino (14076743), Jeremy Florman (14076746), Philippe Diaz (1352535), Ana Belén Elgoyhen (14076752), Diego de Mendoza (9693935), Mark J. Alkema (8487948)   +7 more
core   +1 more source

MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer

Cell Death and Disease, 2023
Glycerophospholipid signal and fatty acid metabolism are closely related to the occurrence and progression of tumours, and metabolic reprogramming caused by hydrolytic enzymes plays an important role in gastric cancer (GC).
Qian Yang, Shan Kong, Jiajia Yu, Yanhua Xu, Mei Tao, Shuo Ma, Chenxue Tang, Xianjuan Shen, Zhiyuan Tang, Shaoqing Ju   +9 more
doaj   +1 more source