Results 21 to 30 of about 11,683 (171)

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro

BMC Pharmacology and Toxicology, 2022
Background Pain relief remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far have low to moderate efficiencies with significant untoward side effects. FAAH-1 has been proposed as a
Julius T. Dongdem, Gideon K. Helegbe, Kwame Opare-Asamoah, Cletus A. Wezena, Augustine Ocloo   +4 more
doaj   +1 more source

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase

Molecules, 2016
Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties.
Yan Qiu, Yang Zhang, Yuhang Li, Jie Ren
doaj   +1 more source

Predicting the bioactive compounds of Lentinula edodes and elucidating its interaction with genes associated to obesity through network pharmacology and in-vitro cell-based assay

Heliyon
Mushrooms are traditionally used for various medicinal purposes in traditional oriental medicine. The Japanese and Chinese are familiar with the medicinal macro fungus Lentinula edodes (Shiitake mushroom). This study aims to evaluate the role of chemical
Jasmeet Kaur, Humaira Farooqi, Kailash Chandra, Bibhu Prasad Panda   +3 more
doaj   +1 more source

Overexpression of fatty acid amide hydrolase induces early flowering in Arabidopsis thaliana

Frontiers in Plant Science, 2012
N-Acylethanolamines (NAEs) are bioactive lipids derived from the hydrolysis of the membrane phospholipid N-acylphosphatidylethanolamine (NAPE). In animal systems this reaction is part of the endocannabinoid signaling pathway, which regulates a variety of
Neal D. Teaster, Jantana eKeereetaweep, Aruna eKilaru, Yuh-Shuh eWang, Yuhong eTang, Christopher N-Q Tran, Brian G. Ayre, Kent D. Chapman, Elison B. Blancaflor   +8 more
doaj   +1 more source

Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer’s Disease Patients

Biomolecules, 2021
Growing evidence shows that the immune system is critically involved in Alzheimer’s disease (AD) pathogenesis and progression. The modulation and targeting of peripheral immune mechanisms are thus promising therapeutic or preventive strategies for AD ...
Valerio Chiurchiù, Lucia Scipioni, Beatrice Arosio, Daniela Mari, Sergio Oddi, Mauro Maccarrone   +5 more
doaj   +1 more source

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.

PLoS ONE, 2015
BackgroundIncreased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile is 2-(2-fluorobiphenyl-4-yl)-
Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J Fowler   +8 more
doaj   +1 more source

Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study[S]

Journal of Lipid Research, 2011
Chronic alcohol consumption is associated with fatty liver disease in mammals. The object of this study was to gain an understanding of dysregulated lipid metabolism in alcohol-fed C57BL/6 mice using a targeted lipidomic approach.
Robin D. Clugston, Hongfeng Jiang, Man Xia Lee, Roseann Piantedosi, Jason J. Yuen, Rajasekhar Ramakrishnan, Michael J. Lewis, Max E. Gottesman, Li-Shin Huang, Ira J. Goldberg, Paul D. Berk, William S. Blaner   +11 more
doaj   +1 more source

Tetracosahexaenoylethanolamide, a novel N-acylethanolamide, is elevated in ischemia and increases neuronal output

Journal of Lipid Research, 2020
N-acylethanolamines (NAEs) are endogenous lipid-signaling molecules derived from fatty acids that regulate numerous biological functions, including in the brain.
Lin Lin, Adam H. Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet   +8 more
doaj   +1 more source

Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition

Cells, 2022
Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease” electing multitarget compounds as potential therapeutic tools suitable for the treatment of complex diseases, such as metabolic syndrome, psychiatric or degenerative
Alessandro Papa, Silvia Pasquini, Chiara Contri, Sandra Gemma, Giuseppe Campiani, Stefania Butini, Katia Varani, Fabrizio Vincenzi   +7 more
doaj   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source