Results 21 to 30 of about 13,359 (214)

Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors [PDF]

ACS Omega, 2018
Fatty acid amide hydrolase (FAAH) is responsible for regulating concentrations of the endocannabinoid arachidonoyl ethanolamide. Multiple FAAH inhibitors have been developed for clinical trials and have failed to demonstrate efficacy at treating pain ...
Sean D. Kodani, Debin Wan, Karen M. Wagner, Sung Hee Hwang, Christophe Morisseau, Bruce D. Hammock   +5 more
doaj   +2 more sources

Fatty acid amide hydrolase and 9-lipoxygenase modulate cotton seedling growth by ethanolamide oxylipin levels. [PDF]

Plant Physiol, 2023
Article asserts that polyunsaturated N-acylethanolamines (NAEs) can be hydrolyzed by fatty acid amide hydrolase (FAAH) or oxidized by lipoxygenase (LOX).
Arias-Gaguancela O, Aziz M, Chapman KD.
europepmc   +2 more sources

Fatty acid amide hydrolase protein sequences.

, 2021
The amino acid sequences of Homo sapiens, Schistosoma mekongi, Schistosoma japonicum, Schistosoma mansoni, Schistosoma haematobium, Schistosoma bovis, Fasciola hepatica, Paragonimus westermani, Clonorchis sinensis, and Echinococcus granulosus fatty acid ...
Phornpimon Tipthara (1784512), Phiraphol Chusongsang (5644022), Yupa Chusongsang (5644025), Joel Tarning (387123), Yanin Limpanont (847321), Onrapak Reamtong (1392406), Peerut Chienwichai (6521324), Poom Adisakwattana (5735363)   +7 more
core   +1 more source

Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]

, 2014
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Mauro, Claudio; id_orcid, Paula Urquhart, Mauro, Claudio, Mauro, C, Anna Nicolaou, Nicolaou, A, Urquhart, P, Urquhart, Paula, Claudio Mauro, Marelli-Berg, F, Nicolaou, Anna; id_orcid, Anna eNicolaou, Paula eUrquhart, Federica eMarelli-Berg, Federica Marelli-Berg, Claudio eMauro, Marelli-Berg, Federica, Nicolaou, Anna   +17 more
core   +1 more source

Conformational Effects in Enzyme Catalysis: Reaction via a High Energy Conformation in Fatty Acid Amide Hydrolase [PDF]

, 2007
Quantum mechanics/molecular mechanics and molecular dynamics simulations of fatty acid amide hydrolase show that reaction (amide hydrolysis) occurs via a distinct, high energy conformation.
Mulholland, Adrian J, Lodola, A, MULHOLLAND AJ, Mulholland, AJ, Mor, Marco, ZUREK J, Harvey, Jeremy N, Lodola, Alessio, Tarzia, Giorgio, TARZIA G, Zurek, Jolanta, Zurek, J, HARVEY JN, Piomelli, D, Mulholland, Adrian J., Harvey, Jeremy N., Tarzia, G, Piomelli, Daniele, PIOMELLI D, Harvey, JN, Mor, M   +20 more
core   +1 more source

Assessment of the effects of CNR1, FAAH and MGLL gene variations on the synthetic cannabinoid use disorder

Türk Biyokimya Dergisi, 2023
Given that drug addiction occurs as a result of complex gene-environment interaction, a number of studies claimed that cannabinoid receptor 1 (CNR1), fatty acid amide hydrolase (FAAH), and monoacylglycerol lipase (MGLL) single nucleotide polymorphisms ...
Altun Beril, Cok Ismet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source

R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids [PDF]

, 2010
Background: R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Julia Metzner, Ziebell, Simone, Koch, Marco, Myrczek, Thekla, Marian, Claudiu, Dehghani, Faramarz, Rohini Kuner, Schmidt Helmut, Bechmann Ingo, Marian Claudiu, Nina Wijnvoord, Dehghani Faramarz, Philipp Bishay, Bishay, Philipp, Kuner, Rohini, Helmut Schmidt, Faramarz Dehghani, Koch Marco, Bechmann, Ingo, Metzner, Julia, Geisslinger Gerd, Irmgard Tegeder, Tegeder Irmgard, Simone Ziebell, Wijnvoord, Nina, Tegeder, Irmgard, Claudiu Marian, Kuner Rohini, Costigan, Michael, Wijnvoord Nina, Annett Häussler, Ingo Bechmann, Michael Costigan, Schmidt, Helmut, Häussler, Annett, Bechmann, Ingo Jürgen, Myrczek Thekla, Bishay Philipp, Häussler Annett, Marco Koch, Costigan Michael, Thekla Myrczek, Metzner Julia   +45 more
core   +1 more source

Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.

PLoS ONE, 2014
BackgroundThe endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake ...
Emmelie Björklund, Anders Blomqvist, Joel Hedlin, Emma Persson, Christopher J Fowler   +4 more
doaj   +1 more source

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro

BMC Pharmacology and Toxicology, 2022
Background Pain relief remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far have low to moderate efficiencies with significant untoward side effects. FAAH-1 has been proposed as a
Julius T. Dongdem, Gideon K. Helegbe, Kwame Opare-Asamoah, Cletus A. Wezena, Augustine Ocloo   +4 more
doaj   +1 more source

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase

Molecules, 2016
Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties.
Yan Qiu, Yang Zhang, Yuhang Li, Jie Ren
doaj   +1 more source