Results 21 to 30 of about 20,213 (210)
Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations [PDF]
HeliyonSimultaneous inhibition of soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) with a single small molecule represents a novel therapeutic approach in treating inflammatory pain, since both targets are involved in pain and inflammation ...
Jeannes Angelia +11 more
doaj +2 more sources
A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase. [PDF]
ScienceUndernutrition in Bangladeshi children is associated with disruption of postnatal gut microbiota assembly; compared with standard therapy, a microbiota-directed complementary food (MDCF) substantially improved their ponderal and linear growth.
Cheng J +4 more
europepmc +2 more sources
4,4-Dimethylsterols Reduces Fat Accumulation via Inhibiting Fatty Acid Amide Hydrolase In Vitro and In Vivo. [PDF]
Research (Wash D C)4,4-Dimethylsterols constitute a unique class of phytosterols responsible for regulating endogenous cannabinoid system (ECS) functions. However, precise mechanism through which 4,4-dimethylsterols affect fat metabolism and the linkage to the ECS remain ...
Zhang T +8 more
europepmc +2 more sources
Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization. [PDF]
Int J Mol Sci, 2021 The ability of endocannabinoid (eCB) to change functional microglial phenotype can be explored as a possible target for therapeutic intervention. Since the inhibition of fatty acid amide hydrolase (FAAH), the main catabolic enzyme of anandamide (AEA ...
Grieco M +9 more
europepmc +2 more sources
Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. [PDF]
Bioorg Med Chem, 2021 Fatty acid amide hydrolase (FAAH) is a membrane protein that hydrolyzes endocannabinoids, and its inhibition produces analgesic and anti-inflammatory effects.
Wilt S +9 more
europepmc +2 more sources
British Journal of Pharmacology, 2022 Devising novel strategies to therapeutically favour inflammation resolution and provide neuroprotection is an unmet clinical need. Enhancing endocannabinoid tone by inhibiting the catabolic enzyme fatty acid amide hydrolase (FAAH), or stimulating ...
M. Cammarota +8 more
semanticscholar +1 more source
New Disulfiram Derivatives as MAGL-Selective Inhibitors
Molecules, 2021 Monoacylglycerol lipase (MAGL) is a key enzyme in the human endocannabinoid system. It is also the main enzyme responsible for the conversion of 2-arachidonoyl glycerol (2-AG) to arachidonic acid (AA), a precursor of prostaglandin synthesis.
Ziad Omran
doaj +1 more source
Fatty acid amide hydrolase is lower in young cannabis users. [PDF]
Addict Biol, 2021 We have recently shown that levels of fatty acid amide hydrolase (FAAH), the enzyme that metabolizes the endocannabinoid anandamide, are lower in the brains of adult cannabis users (CUs) (34 ± 11 years of age), tested during early abstinence.
Jacobson MR +9 more
europepmc +2 more sources
Frontiers in Physiology, 2021 The endocannabinoid system is expressed in cells throughout the body and controls a variety of physiological and pathophysiological functions. We describe robust and reproducible UPLC-MS/MS-based methods for analyzing metabolism of the endocannabinoids ...
Mark B. Wiley +5 more
doaj +1 more source
Pharmaceuticals, 2021 The endocannabinoid system (ECS) plays an integral role in maintaining metabolic homeostasis and may affect hunger, caloric intake, and nutrient absorption.
Justin Matheson +3 more
semanticscholar +1 more source