Results 21 to 30 of about 22,778 (210)

Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX ...
Alessandro Deplano, Jessica Karlsson, Mona Svensson, Federica Moraca, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis   +6 more
doaj   +1 more source

Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation

Journal of Lipid Research, 2013
Percutaneous transluminal angioplasty is frequently used in patients with severe arterial narrowing due to atherosclerosis. However, it induces severe arterial injury and an inflammatory response leading to restenosis.
Filippo Molica, Fabienne Burger, Aurélien Thomas, Christian Staub, Anne Tailleux, Bart Staels, Graziano Pelli, Andreas Zimmer, Benjamin Cravatt, Christian M. Matter, Pal Pacher, Sabine Steffens   +11 more
doaj   +1 more source

Fatty acid amide hydrolase is lower in young cannabis users. [PDF]

Addict Biol, 2021
AbstractWe have recently shown that levels of fatty acid amide hydrolase (FAAH), the enzyme that metabolizes the endocannabinoid anandamide, are lower in the brains of adult cannabis users (CUs) (34 ± 11 years of age), tested during early abstinence. Here, we examine replication of the lower FAAH levels in a separate, younger cohort (23 ± 5 years of ...
Jacobson MR, Watts JJ, Da Silva T, Tyndale RF, Rusjan PM, Houle S, Wilson AA, Ross RA, Boileau I, Mizrahi R.   +9 more
europepmc   +4 more sources

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Fatty Acid Amide Hydrolase (FAAH) is a serine hydrolase that plays a key role in controlling endogenous levels of endocannabinoids. FAAH inhibition is considered a powerful approach to enhance the endocannabinoid signalling, and therefore it has been ...
Alessandro Deplano, Mariateresa Cipriano, Federica Moraca, Ettore Novellino, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis   +6 more
doaj   +1 more source

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation [PDF]

, 2011
The herb Cannabis sativa (C. sativa) has been used in China and on the Indian subcontinent for thousands of years as a medicine. However, since it was brought to the UK and then the rest of the western world in the late 19th century, its use has been a ...
Adams, Agrawal, Ahern, Alger, Armstrong, Arnone, Avraham, Bachur, Baker, Baker, Barbano, Basavarajappa, Basavarajappa, Ben Amar, Ben-Zvi, Berridge, Berridge, Bisogno, Blankman, Bortolato, Breivogel, Brown, Brown, Burkey, Cadas, Cahn, Chan, Childers, Clark, Comelli, Consroe, Costiniuk, Cota, Cota, Cota, Cravatt, Davis, Davis, De Filippis, De Petrocellis, De Petrocellis, Deadwyler, Dennis, Deutsch, Devane, Devane, Dewey, Di Marzo, Di Marzo, Di Marzo, Di Marzo, Di Marzo, Elmquist, Engeli, Evans, Fadda, Farrimond, Farrimond, Felder, Fong, Fonseca, Fredriksson, Freund, Gaetani, Gallate, Gaoni, Gaoni, Gaoni, Gardner, Gatley, Gerdeman, Gill, Glass, Glick, Gomez, Gong, Goutopoulos, Grant, Hao, Henstridge, Henstridge, Herkenham, Herkenham, Higgs, Hohmann, Holland, Hollister, Horswill, Hosohata, Howlett, Howlett, Howlett, Huffman, Hughes, Ishiguro, Izzo, Jamshidi, Jarrett, Jarrett, Jin, Kapur, King, Kirby, Kirkham, Kirkham, Kirkham, Kirkham, Kirkham, Koch, Lambert, Landsman, Lauckner, Lauckner, Ligresti, Little, Liu, Long, Ma, Maccarrone, Maccarrone, Mackie, Mackie, Makriyannis, Martin, Mathes, Matsuda, Mechoulam, Mechoulam, Moldrich, Morgan, Morley, Munro, Naidu, Ning, Ohno-Shosaku, Okamoto, Okamoto, Okamoto, Onaivi, Onaivi, Onaivi, Osei-Hyiaman, Overton, Overton, Oz, Pacheco, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Petitet, Petrosino, Pietr, Piomelli, Piomelli, Piomelli, Pope, Pryce, Pryce, Putney, Rao, Riedel, Rinaldi-Carmona, Rinaldi-Carmona, Rodriguez de Fonseca, Ronesi, Ross, Ross, Ryan, Ryberg, Sanger, Sawzdargo, Schweitzer, Showalter, Simiand, Sink, Sofia, Soga, Solinas, Staton, Stratford, Sugiura, Sugiura, Sugiura, Südhof, Takeda, Thomas, Thornton-Jones, Tramer, Tsou, Turu, Van Gaal, Van Sickle, Vandevoorde, Walsh, Wang, Werner, Whalley, Wiley, Wilkinson, Williams, Williams, Williams, Williams, Williamson, Wilson, Woolridge, Yamauchi, Yan, Yates, Yoshida, Zhu   +215 more
core   +3 more sources

Sulfonyl Fluoride Inhibitors of Fatty Acid Amide Hydrolase [PDF]

Journal of Medicinal Chemistry, 2012
Sulfonyl fluorides are known to inhibit esterases. Early work from our laboratory has identified hexadecyl sulfonylfluoride (AM374) as a potent in vitro and in vivo inhibitor of fatty acid amide hydrolase (FAAH). We now report on later generation sulfonyl fluoride analogs that exhibit potent and selective inhibition of FAAH.
Shakiru O, Alapafuja, Spyros P, Nikas, Indu T, Bharathan, Vidyanand G, Shukla, Mahmoud L, Nasr, Anna L, Bowman, Nikolai, Zvonok, Jing, Li, Xiaomeng, Shi, John R, Engen, Alexandros, Makriyannis   +10 more
openaire   +2 more sources

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Assessment of the effects of CNR1, FAAH and MGLL gene variations on the synthetic cannabinoid use disorder

Türk Biyokimya Dergisi, 2023
Given that drug addiction occurs as a result of complex gene-environment interaction, a number of studies claimed that cannabinoid receptor 1 (CNR1), fatty acid amide hydrolase (FAAH), and monoacylglycerol lipase (MGLL) single nucleotide polymorphisms ...
Altun Beril, Cok Ismet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source

Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women [PDF]

, 2010
N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake.
Balvers, M.G.J., Hendriks, H.F.J., Joosten, M.M., Verhoeckx, K.C.M., Witkamp, R.F.   +4 more
core   +2 more sources

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources