Results 71 to 80 of about 17,658,570 (203)

2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex

, 2017
2-Arachidonoylglycerol and anandamide are the main endocannabinoids, which act through cannabinoid type-1 and type-2 receptors. Among its many functions, anandamide modulates anxiety-like behaviors in the ventromedial prefrontal cortex.
Fabricio A Moreira, Francisco S Guimaraes, Daniele C Aguiar, Ana F Almeida-Santos   +3 more
core   +1 more source

Investigating the effect of enzymatic elimination of endocannabinoids inhibitors on tonic- colonic seizure provoked by PTZ

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2016
BACKGROUND AND OBJECTIVE: In recent years, numerous attempts were done to find new treatment methods for patients with drug-resistant epilepsy. Anandamide (Anandamides; AEA) and di-Arachidonoylglycerol (2-Arachidonoylglycerol; 2-AG) are two major ligands
P Zareie, M Sadegh, MR Palizvan
doaj  

Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study

Addiction, Volume 121, Issue 5, Page 1179-1189, May 2026.
Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
María Salud García‐Gutiérrez, Abraham Bailén Torregrosa, Francisco Navarrete, Auxiliadora Aracil‐Fernández, Gabriel Rubio, Jorge Manzanares   +5 more
wiley   +1 more source

Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum

, 2008
Of the endocannabinoids (eCBs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG) havereceived the most study. A functional interaction between these molecules has never been described. Using mouse brain slices, we found that stimulation of metabotropic
Musella A, Bernardi G, Maccarrone M, Finazzi-Agro A, Fezza F, Cravatt BF, De Chiara V, Gasperi V, Prosperetti C, Centonze D, Rossi S, Bari M   +11 more
core   +2 more sources

Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition

Acta Pharmaceutica Sinica B
Drug repurposing offers an efficient approach to therapeutic development. In this study, our bioinformatic analysis first predicted an association between obesity and lansoprazole (LPZ), a commonly prescribed drug for gastrointestinal ulcers.
Yingting Wu, Jiaqi Xin, Xinyu Li, Ting Yang, Yi Liu, Yongsheng Zhao, Wen Xie, Mengxi Jiang   +7 more
doaj   +1 more source

Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma

Journal of Lipid Research, 2010
The endocannabinoid metabolome consists of a growing, (patho)physiologically important family of fatty-acid derived signaling lipids. Diet is a major source of fatty acid substrate for mammalian endocannabinoid biosynthesis. The principal long-chain PUFA
JodiAnne T. Wood, John S. Williams, Lakshmipathi Pandarinathan, David R. Janero, Carol J. Lammi-Keefe, Alexandros Makriyannis   +5 more
doaj   +1 more source

The effects of exercise on circulating endocannabinoid levels—a protocol for a systematic review and meta-analysis

Systematic Reviews, 2022
Background Increased circulating endocannabinoids levels are typically associated with aerobic exercise. This phenomenon is associated with a “runner’s high,” a state of euphoria and well-being experienced after a long exercise.
Viviane Bristot, Giorgio Poletto, Débora Maria Russiano Pereira, Melina Hauck, Ione Jayce Ceola Schneider, Aderbal S. Aguiar   +5 more
doaj   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Review: “The Disappointment Dilemma: Short‐ and Long‐Term Learning From Negative Outcomes”

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
The habenula routes negative‐outcome signals to VTA, RMTg, and IPN to shape aversive learning and motivation. The lateral habenula encodes acute negative prediction errors to rapidly adapt behavior to threat, fear, and avoidance. The medial habenula integrates repeated stress, drug, and aversive experiences into long‐term negative mood and expectations.
Ines Ibañez‐Tallon, Susanna Molas, Christophe D. Proulx, Joaquin Piriz, Edgar Soria‐Gómez   +4 more
wiley   +1 more source

Anandamide Inhibits Vascular Smooth Muscle Migration, Endothelial Adhesion Protein Expression and Monocyte Adhesion of Human Coronary Artery Cells

Cells
Endocannabinoids have been shown to play a complex role in the pathophysiology of a number of cardiovascular disorders. In the present study, the effects of the two major endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were ...
Elane Blessing, Elisa Teichmann, Burkhard Hinz   +2 more
doaj   +1 more source