Results 81 to 90 of about 17,658,570 (203)
Towards Mechanism‐Informed Treatments for Mental Health
Journal of Neurochemistry, Volume 170, Issue 5, May 2026.Neuropsychiatric disorders impose a major global health burden, and current treatments, which historically mostly targeted dopamine and serotonin dysfunctions, often provide only partial, symptomatic relief. This review highlights emerging evidence that additional neuromodulator systems, including acetylcholine, norepinephrine, and endocannabinoids ...
Iker Bengoetxea de Tena +27 more
wiley +1 more source
Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models
AGING MEDICINE, Volume 9, Issue 2, Page 168-184, April 2026.CB1 receptor (CB1R) expression was significantly reduced in the hippocampus, medial frontal gyrus, and superior temporal gyrus of Alzheimer's patients. CB1R levels negatively correlated with amyloid‐β and tau pathology. In addition, CB1R expression was also reduced in the cortex of 5xFAD mice and in the hippocampus of Tg4‐42 mice.
Nike von Borcke +4 more
wiley +1 more source
UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Migraine
Brain and Behavior, Volume 16, Issue 4, April 2026.This case series followed patients receiving medicinal cannabis for migraine headache for up to 2 years. At 24 months, there were significant improvements in measures assessing headache impact, anxiety, sleep quality, and general quality of life. Note that 15.27% of patients reported an adverse event, most of which were mild or moderate in severity ...
Lennon Hooper +8 more
wiley +1 more source
Pathological Roles of Astrocytes in Traumatic Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu +7 more
wiley +1 more source
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol
Chemistry & Biology, 2007 The endocannabinoid system is the signaling network hijacked by the active component of marijuana, tetrahydrocannibinol (THC), which elicits its effects by activating the cannabinoid (CB) receptors. The endogenous ligands of the CB receptors (“endocannabinoids”) include the lipid transmitters anandamide and 2‐arachidonoyl glycerol (2‐AG ...
Blankman, Jacqueline L. +2 more
openaire +2 more sources
, 2018 Cyclooxygenase-2 (COX-2) catalyzes the formation of prostaglandins, which are involved in immune regulation, vascular function, and synaptic signaling. COX-2 also inactivates the endogenous cannabinoid (eCB) 2-arachidonoylglycerol (2-AG) via oxygenation ...
Amanda J. Morgan (5192720) +7 more
core +1 more source
Lower circulating endocannabinoid levels in children with autism spectrum disorder
Molecular Autism, 2019 Background The endocannabinoid system (ECS) is a major regulator of synaptic plasticity and neuromodulation. Alterations of the ECS have been demonstrated in several animal models of autism spectrum disorder (ASD). In some of these models, activating the
Adi Aran +9 more
doaj +1 more source
Liver International, Volume 46, Issue 4, April 2026.ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Jerome Lian +3 more
wiley +1 more source
Endogenous Cannabinoid Receptor Ligands—Anandamide and 2‐Arachidonoylglycerol
ChemInform, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
openaire +3 more sources
, 2013 Effects of ciclosporine (A) and palmitoylethanolamide (PEA, B) on the vasorelaxation evoked by 2-arachidonoylglycerol (2-AG) in rat isolated mesenteric arterial segments.
Peter M. Zygmunt (241661) +12 more
core +1 more source