Results 81 to 90 of about 12,036 (214)

Endocannabinoid 2-Arachidonoylglycerol Protects Neurons by Limiting COX-2 Elevation [PDF]

Journal of Biological Chemistry, 2008
Endocannabinoids are involved in synaptic signaling and neuronal protection; however, our understanding of the mechanisms by which endocannabinoids protect neurons from harmful insults remains elusive. 2-Arachidonoylglycerol (2-AG), the most abundant endogenous cannabinoid and a full agonist for cannabinoid receptors (CB1 and CB2), is a substrate for ...
Jian, Zhang, Chu, Chen
openaire   +2 more sources

Pitfalls in measuring the endocannabinoid 2-arachidonoyl glycerol in biological samples [PDF]

, 2007
Background: The endocannabinoid 2-arachidonoyl glycerol (2-AG) undergoes spontaneous isomerization to biologically inactive 1-AG. This effect has not been adequately addressed in previous studies that reported 2-AG concentrations in biological samples ...
Schelling, Gustav, Vogeser, Michael
core   +1 more source

Pathological Roles of Astrocytes in Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu, Yuxiao Ma, Baofeng Wang, Yongtao Zheng, Jie Ren, Qingfang Sun, Liuguan Bian, Yuhao Sun   +7 more
wiley   +1 more source

Investigating the effect of enzymatic elimination of endocannabinoids inhibitors on tonic- colonic seizure provoked by PTZ

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2016
BACKGROUND AND OBJECTIVE: In recent years, numerous attempts were done to find new treatment methods for patients with drug-resistant epilepsy. Anandamide (Anandamides; AEA) and di-Arachidonoylglycerol (2-Arachidonoylglycerol; 2-AG) are two major ligands
P Zareie, M Sadegh, MR Palizvan
doaj  

Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner [PDF]

, 2016
Cannabinoid receptor interacting protein 1a (CRIP1a) is a CB1 receptor (CB1R) distal C-terminus-associated protein that modulates CB1R signaling via G proteins, and CB1R down-regulation but not desensitization (Blume et al.
Bass, Caroline E., Blumes, Lawrence C, Chen, Rong, Howlett, Allyn C., Leone-Kabler, Sandra, Luessen, Deborah J., Lyons, Erica, Marrs, Glenn S., Selley, Dana E.   +8 more
core   +2 more sources

Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Jerome Lian, Ricky R Lareu, Mohan Patil, Marco Falasca   +3 more
wiley   +1 more source

Anandamide Inhibits Vascular Smooth Muscle Migration, Endothelial Adhesion Protein Expression and Monocyte Adhesion of Human Coronary Artery Cells

Cells
Endocannabinoids have been shown to play a complex role in the pathophysiology of a number of cardiovascular disorders. In the present study, the effects of the two major endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were ...
Elane Blessing, Elisa Teichmann, Burkhard Hinz   +2 more
doaj   +1 more source

Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function [PDF]

, 2015
Cannabis is a complex substance that harbors terpenoid-like compounds referred to as phytocannabinoids. The major psychoactive phytocannabinoid found in cannabis ∆9-tetrahydrocannabinol (THC) produces the majority of its pharmacological effects through ...
Cabral, Guy A., Lichtman, Aron H, Rogers, Thomas J   +2 more
core   +3 more sources

An α/β‐Hydrolase GmABHD6 Controls Seed Oil Content and Yield in Soybean

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2040-2055, April 2026.
ABSTRACT Seed oil content is a key trait in soybean, yet its genetic basis remains largely unresolved. Here, we identify GmABHD6, an α/β‐hydrolase domain‐containing gene, as the causal gene underlying a major quantitative trait locus (QTL) for seed oil content on chromosome 16.
Kaixin Yu, Limin Hu, Bo Sun, Zehao Chen, Xu Li, Shiyu Zhang, Huilin Tian, Wenjing Zhang, Shimin Ren, Xue Han, Chang Xu, Siming Wei, Mingliang Yang, Fanjiang Kong, Qingshan Chen, Zhaoming Qi   +15 more
wiley   +1 more source

Interplay between n-3 and n-6 long-chain polyunsaturated fatty acids and the endocannabinoid system in brain protection and repair. [PDF]

, 2017
The brain is enriched in arachidonic acid (ARA) and docosahexaenoic acid (DHA), long-chain polyunsaturated fatty acids (LCPUFA) of the n-6 and n-3 series, respectively. Both are essential for optimal brain development and function.
A Artmann, A Berger, A Bilkei-Gorzo, A Chicca, A Nadjar, A Petroni, A Piyanova, A Tanimura, A Thomazeau, A Thomazeau, A Viader, AA Farooqui, AE Bonnet, AF Domenichiello, AJ Vecchio, AL Groeger, AM Fjell, AP Simopoulos, B Batetta, B Lands, B Lu, BM Fonseca, BN Ames, C Arnold, C Canugovi, C Cipollina, CD Breder, CD Buckley, CE Ramsden, CN Serhan, CN Serhan, CN Serhan, CN Serhan, CT Chen, D Bagga, D Ehninger, D Kempuraj, D Leung, D Piomelli, D Rueda, DK Nomura, E Lien, E Mantzioris, E Molina-Holgado, E Ryberg, EA Placzek, EM Novak, ES Onaivi, G Kaur, GA Garden, GF Grabner, H Sprecher, H Yang, H Yang, HG Kuhn, I Galve-Roperh, I Katona, I Matias, J Liu, JC DeMar Jr, JC Demar Jr, JE Tungen, JF Quinn, JL Harrison, JM Parent, JP Pan, JR Savinainen, JT Wood, JW Phillis, JY Xu, K Jin, K Tsuboi, K Yamagata, K Yurko-Mauro, KD Patel, KD Stark, KE Hopperton, KS Broughton, L Belayev, L Petrocellis De, M Alhouayek, M Aursnes, M Gabbs, M Gabrielli, M Kano, M Lafourcade, M Mecha, M Ouellet, M Perluigi, M Zhu, MA Rashid, MB Goncalves, ME Tremblay, MG Cascio, MK Gregory, MR Flock, MV Sofroniew, MV Sofroniew, N Murataeva, N Murataeva, N Stella, NG Bazan, NG Bazan, NG Bazan, NG Bazan, NR Yerram, P Urquhart, PE Castillo, PJ Jones, PK Yip, R Luostarinen, R Micha, R Yang, RJ Kulmacz, S Forsyth, S Watanabe, S Zelasko, SA Moore, SC Dyall, SC Dyall, SC Dyall, SC Dyall, SC Dyall, SC Strike, SE O’Sullivan, Simon C. Dyall, SN Lim, SU Kim, T Aguado, T Bartsch, T Cassano, T Cederholm, T Larrieu, T Takizawa, TVP Bliss, V Chhor, V Darsalia, V Marzo Di, V Marzo Di, V Smedt-Peyrusse De, W Jiang, WL Huang, X Chen, Y Marchalant, Y Takagi, Y Tian, YC Yung, ZZ Xu   +147 more
core   +1 more source