Results 81 to 90 of about 24,579,074 (168)

Physiological Adaptations and Serum-Based Biomarker Dynamics During Multimodal Rehabilitation in Chronic Pain: Analysis of a Prospective Cohort Study

Biomolecules
Background: Chronic pain is a multifactorial condition for which interdisciplinary multimodal rehabilitation is guideline-recommended, yet the biological mechanisms underlying treatment response remain incompletely understood and validated predictive ...
Meike Meinzer, Markus Bassler, Franziska Kessemeier, Corinna Webering, Detlef Neumann, Heike Bähre, Ralf Lichtinghagen, Mathias Rhein, Johannes Achenbach, Christoph Gutenbrunner, Matthias Karst   +10 more
doaj   +1 more source

A Minimally Invasive LC–MS/MS Approach for Assessing Endocannabinoids in Saliva and Capillary Blood Microsamples

Biosensors
N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) are lipid signalling molecules within the endocannabinoid system, which regulates numerous physiological processes and is implicated in diverse pathological conditions.
Jessica Hargreaves, Gabrielle Eddes, David S. Nichols, Luke J. Ney   +3 more
doaj   +1 more source

Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism

, 2008
A series of 21 analogues of tetrahydrolipstatin (THL, 1) were synthesized and tested as inhibitors of the formation or hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG).
NALLI, Marianna, MORERA, ENRICO, Giorgio Ortar, Tiziana Bisogno, Alessia Ligresti, Vincenzo Di Marzo   +5 more
core   +1 more source

The Endocannabinoid System in Neuropsychiatric Disorders: Mechanisms, Dysregulation and Therapeutic Potential

Biomedicines
The endocannabinoid system (ECS) is a fundamental regulator of brain and body homeostasis, integrating neural, immune, and stress-related signaling pathways. Dysregulation of ECS components, including cannabinoid receptors (CB1 and CB2), endocannabinoids
Timur Mušić, Tamara Lah Turnšek
doaj   +1 more source

Genetic screening for SACS, ABHD12 and PRICKLE1 mutations in ataxia patients from Southern Italy [PDF]

, 2011
Genetic screening for SACS, ABHD12 and PRICKLE1 mutations in ataxia patients from Southern Italy. INTRODUCTION Autosomal recessive (AR) spinocerebellar ataxias constitute a heterogeneous group of neurodegenerative disorders mainly characterized by ...
De Leva, Maria Fulvia
core   +1 more source

Tetrahydrolipstatin Analogues as Modulators of Endocannabinoid 2-Arachidonoylglycerol Metabolism

, 2016
A series of 21 analogues of tetrahydrolipstatin (THL, 1) were synthesized and tested as inhibitors of the formation or hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG).
Enrico Morera (2409487), Giorgio Ortar (2409484), Alessia Ligresti (250102), Tiziana Bisogno (356705), Vincenzo Di Marzo (203722), Marianna Nalli (1549969)   +5 more
core   +1 more source

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain [PDF]

, 2018
2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor.
Maccarrone, M., Mauro Maccarrone, Stelt, M. van der, Marc P. Baggelaar, Mario van der Stelt, Baggelaar, M.P.   +5 more
core   +1 more source

Might modulation of the endocannabinoid system provide a potential dual therapeutic strategy for osteoporosis and depression?

General Psychiatry, Volume 39, Issue 4, August 2026.
Peng Wei, Pianpian Zhao, Zenghui Gu, Mengyuan Yang, David Karasik, Ching‐Lung Cheung, Houfeng Zheng   +6 more
wiley   +1 more source

Δ9-Tetrahydrocannabinol induces endocannabinoid accumulation in mouse hepatocytes: antagonism by Fabp1 gene ablation

Journal of Lipid Research, 2018
Phytocannabinoids, such as Δ9-tetrahydrocannabinol (THC), bind and activate cannabinoid (CB) receptors, thereby “piggy-backing” on the same pathway's endogenous endocannabinoids (ECs).
Avery L. McIntosh, Gregory G. Martin, Huan Huang, Danilo Landrock, Ann B. Kier, Friedhelm Schroeder   +5 more
doaj   +1 more source

The monoacylglycerol lipase inhibitors MAFP and JZL184 potentiate 2-arachidonoylglycerol and 1-arachidonoylglycerol sensory nerve-mediated vasodilation.

, 2013
(A) Concentration-response curves for (i) 2-arachidonoylglycerol (2-AG), (ii) 1-arachidonoylglycerol (1-AG), and (iii) anandamide (AEA) in the presence of MAFP (n = 6–11), JZL184 (n = 6–8) or vehicle (n = 13–18).
Peter M. Zygmunt (241661), Anna Ermund (241659), Bryndis Birnir (113570), Alain Eschalier (209750), Stuart Bevan (303154), Bo A. G. Jönsson (241660), Edward D. Högestätt (241662), Charlotte Simonsen (441655), Pouya Movahed (491625), Christophe Mallet (241657), David A. Andersson (303152), Ana Gomis (491626), Anders Blomgren (441654)   +12 more
core   +1 more source