Results 101 to 110 of about 12,036 (214)

A chemical biology approach to control endocannabinoid biosynthesis [PDF]

, 2015
Endocannabinoids play an essential role in human health and disease, regulating processes such as immunomodulation, energy balance and neurotransmission.
Van der Selt, Marcelis
core  

From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System. [PDF]

, 2010
There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The synchronous development of the fertilized embryo and the endometrium to ensure timely implantation has been ...
Abel, Alger, Alpha Gebeh, Anthony H. Taylor, Aquila, Aquila, Aquila, Arnone, Barrett, Battista, Battista, Bisogno, Blankman, Bray, Bray, Carreau, Chabbert Buffet, Chmurzynska, Cobellis, Devane, Devane, Di Marzo, Di Marzo, Di Marzo, Dinh, El-Talatini, El-Talatini, Evers, Fonseca, Francavilla, Furuhashi, Geber, Gervasi, Godlewski, Gong, Grimaldi, Guo, Guzeloglu-Kayisli, Habayeb, Habayeb, Habayeb, Habayeb, Helliwell, Horne, Idris, Jonathon M. Willets, Justin C. Konje, Kaczocha, Katerina N. Bambang, Kim, Lambert, Larqué, Leung, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maingret, Matsuda, Mechoulam, Mechoulam, Meizel, Muccioli, Munro, Newton, Nixon, O'Sullivan, Okamoto, Pan, Pandey, Paria, Paria, Paria, Paria, Paria, Park, Patricia Lam, Pestonjamasp, Piccini, Pierantoni, Ravinet Trillou, Regan, Rodriguez de Fonseca, Rodriguez de Fonseca, Ross, Rossato, Rossi, Schmid, Schuel, Schuel, Schuel, Schuel, Simiand, Sipe, Smith, Sofikitis, Sriraman, Sun, Tapia, Taylor, Taylor, Timothy H. Marczylo, Toth, Trabucco, Tsuboi, Tulay Karasu, Turco, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wei, Wenger, Wenger, Yamano, Yang   +125 more
core   +2 more sources

Unraveling Endocannabinoid Signaling Pathways in Cisplatin‐Induced Ototoxicity

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
We performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Sakthimala Palaniappan, Annamaria Tisi, Camilla Di Meo, Cristina Urbano, Georgina E. Fenton, Francesco Della Valle, Federico Fanti, Dario Compagnone, Marc Nazarè, Huib Versnel, Andrea Aramini, Marcello Allegretti, Mauro Maccarrone   +12 more
wiley   +1 more source

Oxyradical Stress, Endocannabinoids, and Atherosclerosis

Toxics, 2015
Atherosclerosis is responsible for most cardiovascular disease (CVD) and is caused by several factors including hypertension, hypercholesterolemia, and chronic inflammation.
Anberitha T. Matthews, Matthew K. Ross
doaj   +1 more source

Role of cannabinoids in the regulation of bone remodeling [PDF]

, 2012
The endocannabinoid system plays a key role in regulating a variety of physiological processes such as appetite control and energy balance, pain perception, and immune responses. Recent studies have implicated the endocannabinoid system in the regulation
Idris, Aymen I, Ralston, Stuart H
core   +2 more sources

Novel Technologies for Exploring the Skin–Brain Axis

Advanced Sensor Research, Volume 5, Issue 2, February 2026.
The skin–brain axis mediates bidirectional communication between cutaneous physiology and the nervous system, influencing sensation, inflammation, and disease. This review surveys emerging microsensor, nanosensor, and bioelectronic technologies integrated with advanced skin and neural models, highlighting multimodal, real‐time strategies to decode ...
Dahiana Mojena Medina, Francesca Santoro
wiley   +1 more source

Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition

Acta Pharmaceutica Sinica B
Drug repurposing offers an efficient approach to therapeutic development. In this study, our bioinformatic analysis first predicted an association between obesity and lansoprazole (LPZ), a commonly prescribed drug for gastrointestinal ulcers.
Yingting Wu, Jiaqi Xin, Xinyu Li, Ting Yang, Yi Liu, Yongsheng Zhao, Wen Xie, Mengxi Jiang   +7 more
doaj   +1 more source

Fatty acid modulation of the endocannabinoid system and the effect on food intake and metabolism [PDF]

, 2013
Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system’s role in food intake and glucose and lipid metabolism.
Hryciw, Deanne H, Mathai, Michael, McAinch, Andrew, Naughton, Shaan   +3 more
core   +3 more sources

Palmitoylethanolamide (PEA) regulates cell cycle progression and promotes an anti‐inflammatory transcriptomic signature in C2C12 skeletal muscle cells

Physiological Reports, Volume 14, Issue 4, February 2026.
Abstract Palmitoylethanolamide (PEA) is an endogenous lipid mediator with immunomodulatory actions, yet its effects in skeletal muscle remain poorly defined. We examined whether PEA influences myogenesis and profiled the acute transcriptomic response of differentiated C2C12 myotubes to 10 μM PEA. PEA decreased myotube number (90.3 ± 10.6 vs. 112.6 ± 10.
Paige L. Cole, Scott H. Gillham, Mark R. Viggars, Graeme L. Close, Daniel J. Owens   +4 more
wiley   +1 more source

Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma

Journal of Lipid Research, 2010
The endocannabinoid metabolome consists of a growing, (patho)physiologically important family of fatty-acid derived signaling lipids. Diet is a major source of fatty acid substrate for mammalian endocannabinoid biosynthesis. The principal long-chain PUFA
JodiAnne T. Wood, John S. Williams, Lakshmipathi Pandarinathan, David R. Janero, Carol J. Lammi-Keefe, Alexandros Makriyannis   +5 more
doaj   +1 more source