Results 101 to 110 of about 17,658,570 (203)

Δ9-Tetrahydrocannabinol induces endocannabinoid accumulation in mouse hepatocytes: antagonism by Fabp1 gene ablation

Journal of Lipid Research, 2018
Phytocannabinoids, such as Δ9-tetrahydrocannabinol (THC), bind and activate cannabinoid (CB) receptors, thereby “piggy-backing” on the same pathway's endogenous endocannabinoids (ECs).
Avery L. McIntosh, Gregory G. Martin, Huan Huang, Danilo Landrock, Ann B. Kier, Friedhelm Schroeder   +5 more
doaj   +1 more source

Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2‐Arachidonoylglycerol

, 2009
Biosynthesis Inhibition: O‐5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2‐arachidonoylglycerol, was synthesized and found to be potent (IC50=100 nM) and selective versus other proteins and enzymes of the endocannabinoid system in ...
Di Marzo, Vincenzo, James J. Burston, Jenny L. Wiley, Tiziana Bisogno, Mahadevan, Anu, Ravi Rai, Vincenzo Di Marzo, Anu Mahadevan, Saha, Bijali, Burston, James J., Raj K. Razdan, Wiley, Jenny L., Allarà, Marco, Razdan, Raj K., Bijali Saha, Rai, Ravi, Bisogno, Tiziana, Marco Allarà   +17 more
core   +1 more source

2-Arachidonoylglycerol and 1-arachidonoylglycerol activate heterologously expressed rat and human TRPV1.

, 2013
Current-voltage relationships after application of vehicle (Basal) or 2-arachidonoylglycerol (2-AG, 10 µM) to rat TRPV1-expressing CHO cells in the absence (A) and presence (B) of the protein kinase C inhibitor bisindoylmaleimide IV (BIM; 10 µM).
Peter M. Zygmunt (241661), Anna Ermund (241659), Bryndis Birnir (113570), Alain Eschalier (209750), Stuart Bevan (303154), Bo A. G. Jönsson (241660), Edward D. Högestätt (241662), Charlotte Simonsen (441655), Pouya Movahed (491625), Christophe Mallet (241657), David A. Andersson (303152), Ana Gomis (491626), Anders Blomgren (441654)   +12 more
core   +1 more source

A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol

Journal of Lipid Research, 2014
Microsomal epoxide hydrolase (EPHX1, EC 3.3.2.9) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity.
Kasem Nithipatikom, Michael P. Endsley, Adam W. Pfeiffer, John R. Falck, William B. Campbell   +4 more
doaj   +1 more source

2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts [PDF]

, 2014
Platelets modulate vascular system integrity, and their loss is critical in haematological pathologies and after chemotherapy. Therefore, identification of molecules enhancing platelet production would be useful to counteract thrombocytopenia.
Gasperi, V, Mauro Maccarrone, Chiurchiù, V, ODDI, Sergio, Lanuti, M, Valerio Chiurchiù, Avigliano, L, Oddi, S, CATANI, MARIA VALERIA, AVIGLIANO, LUCIANA, Daniela Evangelista, Maria Valeria Catani, Luciana Avigliano, Evangelista, D, Maccarrone, M, GASPERI, VALERIA, Valeria Gasperi, LANUTI, MIRKO, Catani, MV   +18 more
core   +1 more source

Critical role of the endocannabinoid system in mediating rapid glucocorticoid effects on memory for emotionally arousing experiences

European Journal of Psychotraumatology, 2012
Rationale : There is extensive evidence that glucocorticoid hormones impair the retrieval of memory of emotionally arousing experiences. Although it is known that glucocorticoid effects on memory retrieval impairment depend on rapid interactions with ...
Benno Roozendaal
doaj   +1 more source

Aging modifies the enzymatic activities involved in 2‐arachidonoylglycerol metabolism

BioFactors, 2012
AbstractOne of the principal monoacylglycerol (MAG) species in animal tissues is 2‐arachidonoylglycerol (2‐AG), and the diacylglycerol lipase (DAGL) pathway is the most important 2‐AG biosynthetic pathway proposed to date. Lysophosphatidate phosphatase (LPAase) activity is part of another 2‐AG‐forming pathway in which monoacylglycerol lipase (MAGL) is ...
Pascual, Ana Clara, Gaveglio, Virginia Lucía, Giusto, Norma Maria, Pasquaré, Susana Juana   +3 more
openaire   +3 more sources

2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through Ca2+-dependent and -independent mechanisms

, 1998
The molecular species compositions of monoacylglycerols obtained from various rat tissues were examined by reverse-phase high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) analyses.
Sugiura, Takayuki, Kondo, Hironori, Hironori Kondo, Sachiko Kondo, Tomoko Kodaka, Waku, Keizo, Tokumura, Akira, Kodaka, Tomoko, Kondo, Sachiko, Akira Tokumura, Takayuki Sugiura, Shinji Nakane, Nakane, Shinji, Keizo Waku   +13 more
core   +1 more source

Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

Frontiers in Neuroscience
BackgroundSome evidence suggests that cannabidiol (CBD) has potential to help alleviate HIV symptoms due to its antioxidant and anti-inflammatory properties.
Barkha J. Yadav-Samudrala, Benjamin L. Gorman, Karenna M. Barmada, Havilah P. Ravula, Caitlin J. Huguely, E. Diane Wallace, Michelle R. Peace, Justin L. Poklis, Wei Jiang, Wei Jiang, Sylvia Fitting   +10 more
doaj   +1 more source

Potential of Endocannabinoids to Control Bladder Pain

Frontiers in Systems Neuroscience, 2018
Bladder-related pain is one of the most common forms of visceral pain, and visceral pain is among the most common complaints for which patients seek physician consultation. Despite extensive studies of visceral innervation and treatment of visceral pain,
Dale E. Bjorling, Zun-yi Wang
doaj   +1 more source