Results 91 to 100 of about 17,658,570 (203)

A Minimally Invasive LC–MS/MS Approach for Assessing Endocannabinoids in Saliva and Capillary Blood Microsamples

Biosensors
N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) are lipid signalling molecules within the endocannabinoid system, which regulates numerous physiological processes and is implicated in diverse pathological conditions.
Jessica Hargreaves, Gabrielle Eddes, David S. Nichols, Luke J. Ney   +3 more
doaj   +1 more source

An α/β‐Hydrolase GmABHD6 Controls Seed Oil Content and Yield in Soybean

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2040-2055, April 2026.
ABSTRACT Seed oil content is a key trait in soybean, yet its genetic basis remains largely unresolved. Here, we identify GmABHD6, an α/β‐hydrolase domain‐containing gene, as the causal gene underlying a major quantitative trait locus (QTL) for seed oil content on chromosome 16.
Kaixin Yu, Limin Hu, Bo Sun, Zehao Chen, Xu Li, Shiyu Zhang, Huilin Tian, Wenjing Zhang, Shimin Ren, Xue Han, Chang Xu, Siming Wei, Mingliang Yang, Fanjiang Kong, Qingshan Chen, Zhaoming Qi   +15 more
wiley   +1 more source

The monoacylglycerol lipase inhibitors MAFP and JZL184 potentiate 2-arachidonoylglycerol and 1-arachidonoylglycerol sensory nerve-mediated vasodilation.

, 2013
(A) Concentration-response curves for (i) 2-arachidonoylglycerol (2-AG), (ii) 1-arachidonoylglycerol (1-AG), and (iii) anandamide (AEA) in the presence of MAFP (n = 6–11), JZL184 (n = 6–8) or vehicle (n = 13–18).
Peter M. Zygmunt (241661), Anna Ermund (241659), Bryndis Birnir (113570), Alain Eschalier (209750), Stuart Bevan (303154), Bo A. G. Jönsson (241660), Edward D. Högestätt (241662), Charlotte Simonsen (441655), Pouya Movahed (491625), Christophe Mallet (241657), David A. Andersson (303152), Ana Gomis (491626), Anders Blomgren (441654)   +12 more
core   +1 more source

The Endocannabinoid System in Neuropsychiatric Disorders: Mechanisms, Dysregulation and Therapeutic Potential

Biomedicines
The endocannabinoid system (ECS) is a fundamental regulator of brain and body homeostasis, integrating neural, immune, and stress-related signaling pathways. Dysregulation of ECS components, including cannabinoid receptors (CB1 and CB2), endocannabinoids
Timur Mušić, Tamara Lah Turnšek
doaj   +1 more source

Changes of endocannabinoid plasma levels following type I trauma [PDF]

, 2012
The endocannabinoid system has emerged as one of the most important facilitators of stress adaptation in the body. So far, little to no research took place concerning the endocannabinoid response to stress in humans.
Heimendahl, Jenny von
core  

Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections [PDF]

, 2012
Background: After focal neuronal injury the endocannabinioid system becomes activated and protects or harms neurons depending on cannabinoid derivates and receptor subtypes.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Natsuo Ueda, Ueda Natsuo, Dehghani Faramarz, Faramarz Dehghani (109822), Hobusch Constance, Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Koch Marco, Geisslinger Gerd, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Natsuo Ueda (176896), Constance Hobusch, Kallendrusch Sonja, Ehrlich Angela, Kallendrusch, Sonja, Ueda, Natsuo, Marco Koch, Angela Ehrlich (109799)   +31 more
core   +1 more source

Pitfalls in measuring the endocannabinoid 2-arachidonoyl glycerol in biological samples [PDF]

, 2007
Background: The endocannabinoid 2-arachidonoyl glycerol (2-AG) undergoes spontaneous isomerization to biologically inactive 1-AG. This effect has not been adequately addressed in previous studies that reported 2-AG concentrations in biological samples ...
Schelling, Gustav, Vogeser, Michael
core   +1 more source

Tetrahydrolipstatin Analogues as Modulators of Endocannabinoid 2-Arachidonoylglycerol Metabolism

, 2016
A series of 21 analogues of tetrahydrolipstatin (THL, 1) were synthesized and tested as inhibitors of the formation or hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG).
Enrico Morera (2409487), Giorgio Ortar (2409484), Alessia Ligresti (250102), Tiziana Bisogno (356705), Vincenzo Di Marzo (203722), Marianna Nalli (1549969)   +5 more
core   +1 more source

The regulation of endocannabinoids after neuronal damage and the neuroprotective impact of GPR55 in organotypic hippocampal slice cultures

, 2013
Endocannabinoids (eCB) are signaling lipids and became known for their importance in the central nervous system as well as in immune defense. Beneficial effects of eCB are shown in processes of excitotoxic lesion, secondary damage and neuronal plasticity
Kallendrusch, Sonja
core  

Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.

, 2008
The structure-activity relationships of organophosphorus (OP) and organosulfur compounds were examined in vitro and in vivo as inhibitors of mouse brain monoacylglycerol lipase (MAGL) hydrolysis of 2-arachidonoylglycerol (2-AG) and agonist binding at the
Ward, Anna M, Hudak, Carolyn S.S., Issa, Roger S., Casida, John E, Hudak, Carolyn S S, Burston, James J., Nomura, Daniel K., Abood, Mary E., Lichtman, Aron H, Wiley, Jenny L., Nomura, Daniel K, Issa, Roger S, Abood, Mary E, Wiley, Jenny L, Lichtman, Aron H., Fisher, Karl J, Ward, Anna M., Fisher, Karl J., Casida, John E., Burston, James J   +19 more
core   +1 more source