Results 91 to 100 of about 24,579,074 (168)

Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections [PDF]

, 2012
Background: After focal neuronal injury the endocannabinioid system becomes activated and protects or harms neurons depending on cannabinoid derivates and receptor subtypes.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Natsuo Ueda, Ueda Natsuo, Dehghani Faramarz, Faramarz Dehghani (109822), Hobusch Constance, Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Koch Marco, Geisslinger Gerd, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Natsuo Ueda (176896), Constance Hobusch, Kallendrusch Sonja, Ehrlich Angela, Kallendrusch, Sonja, Ueda, Natsuo, Marco Koch, Angela Ehrlich (109799)   +31 more
core   +2 more sources

Purification and characterization of sn -1-stearoyl-2-arachidonoylglycerol kinase from pig testes [PDF]

, 1997
1-Stearoyl-2-arachidonoylglycerol (SAG) kinase was identified in the particulate fraction of pig testes. This activity was enriched by hydroxyapatite and blue dye chromatography.
ROSE, Sally, GARDNER, Sandra D., PATERSON, Andrew, HODGKIN, Matthew N., MARTIN, Ashley, WAKELAM, Michael J. O.   +5 more
core   +1 more source

A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol

Journal of Lipid Research, 2014
Microsomal epoxide hydrolase (EPHX1, EC 3.3.2.9) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity.
Kasem Nithipatikom, Michael P. Endsley, Adam W. Pfeiffer, John R. Falck, William B. Campbell   +4 more
doaj   +1 more source

Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.

, 2008
The structure-activity relationships of organophosphorus (OP) and organosulfur compounds were examined in vitro and in vivo as inhibitors of mouse brain monoacylglycerol lipase (MAGL) hydrolysis of 2-arachidonoylglycerol (2-AG) and agonist binding at the
Ward, Anna M, Hudak, Carolyn S.S., Issa, Roger S., Casida, John E, Hudak, Carolyn S S, Burston, James J., Nomura, Daniel K., Abood, Mary E., Lichtman, Aron H, Wiley, Jenny L., Nomura, Daniel K, Issa, Roger S, Abood, Mary E, Wiley, Jenny L, Lichtman, Aron H., Fisher, Karl J, Ward, Anna M., Fisher, Karl J., Casida, John E., Burston, James J   +19 more
core   +1 more source

2-Arachidonoylglycerol and 1-arachidonoylglycerol activate heterologously expressed rat and human TRPV1.

, 2013
Current-voltage relationships after application of vehicle (Basal) or 2-arachidonoylglycerol (2-AG, 10 µM) to rat TRPV1-expressing CHO cells in the absence (A) and presence (B) of the protein kinase C inhibitor bisindoylmaleimide IV (BIM; 10 µM).
Peter M. Zygmunt (241661), Anna Ermund (241659), Bryndis Birnir (113570), Alain Eschalier (209750), Stuart Bevan (303154), Bo A. G. Jönsson (241660), Edward D. Högestätt (241662), Charlotte Simonsen (441655), Pouya Movahed (491625), Christophe Mallet (241657), David A. Andersson (303152), Ana Gomis (491626), Anders Blomgren (441654)   +12 more
core   +1 more source

Critical role of the endocannabinoid system in mediating rapid glucocorticoid effects on memory for emotionally arousing experiences

European Journal of Psychotraumatology, 2012
Rationale : There is extensive evidence that glucocorticoid hormones impair the retrieval of memory of emotionally arousing experiences. Although it is known that glucocorticoid effects on memory retrieval impairment depend on rapid interactions with ...
Benno Roozendaal
doaj   +1 more source

Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

Frontiers in Neuroscience
BackgroundSome evidence suggests that cannabidiol (CBD) has potential to help alleviate HIV symptoms due to its antioxidant and anti-inflammatory properties.
Barkha J. Yadav-Samudrala, Benjamin L. Gorman, Karenna M. Barmada, Havilah P. Ravula, Caitlin J. Huguely, E. Diane Wallace, Michelle R. Peace, Justin L. Poklis, Wei Jiang, Wei Jiang, Sylvia Fitting   +10 more
doaj   +1 more source

Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2‐Arachidonoylglycerol

, 2009
Biosynthesis Inhibition: O‐5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2‐arachidonoylglycerol, was synthesized and found to be potent (IC50=100 nM) and selective versus other proteins and enzymes of the endocannabinoid system in ...
Di Marzo, Vincenzo, James J. Burston, Jenny L. Wiley, Tiziana Bisogno, Mahadevan, Anu, Ravi Rai, Vincenzo Di Marzo, Anu Mahadevan, Saha, Bijali, Burston, James J., Raj K. Razdan, Wiley, Jenny L., Allarà, Marco, Razdan, Raj K., Bijali Saha, Rai, Ravi, Bisogno, Tiziana, Marco Allarà   +17 more
core   +1 more source

Bidirectional regulation of endocannabinoid signaling in the amygdala contributes to activation and adaptation of the stress response

European Journal of Psychotraumatology, 2012
Rationale : Endocannabinoids have been shown to be important for the regulation of multiple aspects of the stress response, although the neural circuits underlying this phenomenon are not well characterized.
Matthew N. Hill
doaj   +1 more source

Endogenous Cannabinoids in Crohn’s Disease

Applied Sciences
Background: An increasing number of people around the world suffer from Crohn’s disease (CD), one of the inflammatory bowel diseases (IBDs). Recent evidence suggests that the endogenous cannabinoid system plays an important role in IBD.
Michał S. Bochenek, Jan T. Tomasik, Andrzej Wędrychowicz, Przemysław J. Tomasik   +3 more
doaj   +1 more source