Results 91 to 100 of about 12,036 (214)

Exploring the Therapeutic Potential of Cannabidiol in Cutaneous Squamous Cell Carcinoma: An Integrated Computational and Experimental Study

International Journal of Quantum Chemistry, Volume 126, Issue 5, March 5, 2026.
Cannabidiol (CBD) exhibits increased reactivity, stronger CB1 receptor binding, and enhanced cytotoxicity against A431 squamous carcinoma cells compared to 5‐fluorouracil (5‐FU). Integrated DFT, molecular docking, and experimental analyses demonstrate CBD's improved stability and binding affinity, highlighting its potential as an alternative ...
Andrea Jess Josiah, Krishna Kuben Govender, Penny Poomani Govender, Werner Cordier, Margo Nell, Suprakas Sinha Ray   +5 more
wiley   +1 more source

Endocannabinoid-related compounds in gastrointestinal diseases [PDF]

, 2018
The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro, Esposito, Giuseppe, Gigli, Stefano, Giovanni, Sarnelli, Marcella, Pesce, Osvaldo, Borrelli, Rosario, Cuomo, Seguella, Luisa   +7 more
core   +1 more source

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, Volume 2, Issue 1, Page 23-39, March 2026.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

Aging modifies the enzymatic activities involved in 2‐arachidonoylglycerol metabolism

BioFactors, 2012
AbstractOne of the principal monoacylglycerol (MAG) species in animal tissues is 2‐arachidonoylglycerol (2‐AG), and the diacylglycerol lipase (DAGL) pathway is the most important 2‐AG biosynthetic pathway proposed to date. Lysophosphatidate phosphatase (LPAase) activity is part of another 2‐AG‐forming pathway in which monoacylglycerol lipase (MAGL) is ...
Pascual, Ana Clara, Gaveglio, Virginia Lucía, Giusto, Norma Maria, Pasquaré, Susana Juana   +3 more
openaire   +3 more sources

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]

, 2017
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio, Giustizieri, Michela, Leuti, Alessandro, Lombardi, Marta, Maccarrone, Mauro, Marinelli, Sara, Marinelli, Silvia, Marrone, Maria Cristina, Mattioli, Marzia, Morabito, Annunziato, Murana, Emanuele, Oddi, Sergio, Piomelli, Daniele, Ragozzino, Davide Antonio, Riganti, Loredana, Totaro, Antonio, Verderio, Claudia   +16 more
core   +3 more sources

Differentiating Nonsuicidal Self‐Injury (NSSI) From Suicide Attempts in Adolescents: A Pilot Study

Medicine Bulletin, Volume 2, Issue 2, Page 155-166, March 2026.
ABSTRACT Background Differentiating between nonsuicidal self‐injury (NSSI) and suicide attempts (SA) in adolescents is crucial due to distinct underlying motivations, treatment needs, and potential outcomes associated with each behavior.
María Posada‐Ayala, Ping Wang, Gemma Barroso‐Garcia, Encarnación Donoso‐Navarro, Elena Hernandez‐Alvarez, María Gil‐Ligero, Julián Romero, Silvia Rosado‐Garcia, Antonio José Sánchez‐López, Hilario Blasco‐Fontecilla   +9 more
wiley   +1 more source

Δ9-Tetrahydrocannabinol induces endocannabinoid accumulation in mouse hepatocytes: antagonism by Fabp1 gene ablation

Journal of Lipid Research, 2018
Phytocannabinoids, such as Δ9-tetrahydrocannabinol (THC), bind and activate cannabinoid (CB) receptors, thereby “piggy-backing” on the same pathway's endogenous endocannabinoids (ECs).
Avery L. McIntosh, Gregory G. Martin, Huan Huang, Danilo Landrock, Ann B. Kier, Friedhelm Schroeder   +5 more
doaj   +1 more source

Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain [PDF]

, 2016
BACKGROUND AND PURPOSE: Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate, or are associated with serious side effects. The endocannabinoid system may offer alternative targets for pain-relief.
Alexander, Alexander, Burston, Chan, Chen, Christiansen, Curtis, Elikkottil, Glyn-Jones, Goldring, Gonsiorek, Huffman, Huggins, Ignatowska-Jankowska, Janusz, Juni, Kelly, Kilkenny, Kinsey, Lee, Long, Lysenko, Mapp, McGrath, Niphakis, Nomura, Ogbonna, Okine, Parker, Rani Sagar, Sagar, Sagar, Sagar, Sagar, Sasso, Savinainen, Schlosburg, Sinikallio, Smith, Southan, Woodhams, Yu, Zhang, Zhang   +43 more
core   +5 more sources

Single oral administration of dronabinol increases ocular blood flow in patients with glaucoma

Acta Ophthalmologica, Volume 104, Issue 2, Page 225-232, March 2026.
Abstract Purpose Glaucoma is a leading cause of irreversible blindness globally, primarily driven by elevated intraocular pressure (IOP). Still, some patients progress despite significant IOP lowering, potentially due to impaired ocular blood flow. This study aimed to evaluate the effects of dronabinol, a synthetic tetrahydrocannabinol derivative, on ...
Theresa Lindner, Viktoria Pai, Patrick Janku, Nikolaus Hommer, Anton Hommer, Marihan Abensperg‐Traun, Liudmyla Petric, Leopold Schmetterer, Gerhard Garhöfer, Doreen Schmidl   +9 more
wiley   +1 more source

A Minimally Invasive LC–MS/MS Approach for Assessing Endocannabinoids in Saliva and Capillary Blood Microsamples

Biosensors
N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) are lipid signalling molecules within the endocannabinoid system, which regulates numerous physiological processes and is implicated in diverse pathological conditions.
Jessica Hargreaves, Gabrielle Eddes, David S. Nichols, Luke J. Ney   +3 more
doaj   +1 more source