Results 1 to 10 of about 1,309,192 (242)

Cannabinoid CB₁ allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression. [PDF]

Br J Pharmacol
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Solomon ID, Garai S, Thakur GA, Hohmann AG.   +3 more
europepmc   +2 more sources

Genetically Encoded CB₂R-Based Fluorescent Sensor Enables Rapid Screening and Functional Assessment of Cannabinoid Modulators. [PDF]

Int J Mol Sci
Bhattacharjee P, Volesky PD, Shivshankar S, Puhl H, Iyer MR.   +4 more
europepmc   +1 more source

Cannabinoids in Alzheimer's disease: animal-human evidence and clinical pharmacology challenges. [PDF]

Front Behav Neurosci
Komedera M, Wojda U, Kiryk A.
europepmc   +1 more source

The Therapeutic Paradox of Endocannabinoid Immunomodulation: Molecular Mechanisms and Strategic Frameworks. [PDF]

Int J Mol Sci
Love CR.
europepmc   +1 more source

The Pharmacological Activity of Non-Cannabinoid Phytochemicals in <i>Cannabis sativa</i> L.: A Systematic Review. [PDF]

Plants (Basel)
Sanni O, Ogunrombi MO, Obi CL.
europepmc   +1 more source

Brain cannabinoid CB1 receptor signaling modulates reward responses and inhibitory control in humans. [PDF]

Imaging Neurosci (Camb)
Sun L, Kantonen T, Pekkarinen L, Nuutila P, Nummenmaa L.   +4 more
europepmc   +1 more source

The Endoterpenoid System: A Membrane-Based Logic Framework for Integrating Cannabinoid, Olfactory, and Lipid-Sensitive Receptor Crosstalk. [PDF]

J Neurosci Res
Yarar E, Altundag A, Mason CE, Aschner M, Harbi E.   +4 more
europepmc   +1 more source

Endocannabinoid system attenuates emotional stress-induced orofacial musculoskeletal pain in rats. [PDF]

Braz J Med Biol Res
Silveira SS, Alves BWF, Lisboa MRP, Nogueira JJR, Menezes KLS, Pereira AF, Lima RF, Gondim DV, Vale ML.   +8 more
europepmc   +1 more source

Cannabinoids in Motor Control: From Receptor Distribution to Motor Disorders. [PDF]

Biomedicines
Faganeli D, Lipnik-Stangelj M.
europepmc   +1 more source

Cyclic Monoterpene-Aromatic Hybrids from Chiral Pool Terpenoid Ketones: Practical Synthetic Methodology for Accessing Them and In Silico Assessment as Cannabinoid Receptor CB1/CB2 Ligands. [PDF]

Molecules
Kaikiti V, Jaksic A, Ali B, Georgiades SN.   +3 more
europepmc   +1 more source