Cholesterol as a modulator of cannabinoid receptor CB2 signaling [PDF]
Scientific Reports, 2021 Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases basal ...
Alexei Yeliseev +7 more
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The Role of Cannabinoid Receptors in the Descending Modulation of Pain
Pharmaceuticals, 2010 The endogenous antinociceptive descending pathway represents a circuitry of the supraspinal central nervous system whose task is to counteract pain. It includes the periaqueductal grey (PAG)-rostral ventromedial medulla (RVM)-dorsal horn (DH) axis, which
Francesco Rossi +4 more
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Direct modulation of human GABA-A α1β2γ2 receptors by the endocannabinoid 2-arachidonoylglycerol: implications for cannabinoid-related ligands and limitations for anxiolytic drug development [PDF]
Frontiers in NeuroscienceAnxiety disorders are associated with impaired inhibitory neurotransmission mediated by γ-aminobutyric acid type A (GABA-A) receptors. Although benzodiazepines remain effective anxiolytics, their clinical utility is limited by sedation, cognitive ...
Edgar Mixcoha +6 more
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Endocannabinoid Modulation in Headache: Mechanisms, Models, and Translational Therapies [PDF]
CellsHeadache disorders, including migraine, tension-type headache, trigeminal autonomic cephalalgias, post-traumatic headache and medication overuse headache, represent a major global health burden and remain difficult to treat despite therapeutic advances ...
Jie Wen, Yumin Zhang
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Allosteric Modulators Targeting Cannabinoid cb1 and cb2 Receptors: Implications for Drug Discovery
Future Medicinal Chemistry, 2019 Allosteric modulators of cannabinoid receptors hold great therapeutic potential, as they do not possess intrinsic efficacy, but instead enhance or diminish the receptor's response of orthosteric ligands allowing for the tempering of cannabinoid receptor ...
Simone Bertini +2 more
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Current Topics in Medicinal Chemistry, 2019 The cannabinoid receptor 1 (CBR1) is involved in a variety of physiological pathways and has long been considered a golden target for therapeutic manipulation.
Yanan Zhang +2 more
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Cannabinoid CB1 receptors drive oligodendrocyte maturation during myelin regeneration [PDF]
Cell Communication and SignalingOligodendrocytes, the myelin-producing cells in the central nervous system, derive from oligodendrocyte progenitor cells during both development and remyelination.
Sara Ezquerro-Herce +6 more
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Metabolic disorders: Safe cannabinoid receptor modulators in sight? [PDF]
Nature Reviews Drug Discovery, 2012 Sarah Crunkhorn
semanticscholar +2 more sources
Phytocannabinoids as Novel SGLT2 Modulators for Renal Glucose Reabsorption in Type 2 Diabetes Management [PDF]
PharmaceuticalsBackground: Sodium–glucose cotransporter 2 (SGLT2) inhibitors have transformed type 2 diabetes mellitus (T2DM) management by promoting glucosuria, lowering glycated hemoglobin (HbA1c), blood pressure, and weight; however, their use is limited by ...
Raymond Rubianto Tjandrawinata +4 more
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