Results 41 to 50 of about 1,309,192 (242)

Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome following Traumatic Injury: A Preliminary Report [PDF]

, 2009
The complex regional pain syndrome (CRPS) is a disabling neuropathic pain condition that may develop following injuries of the extremities. The pathogenesis of this syndrome is not clear; however, it includes complex interactions between the nervous and ...
Schelling, G., Huge, V., Kaufmann, I., G. Schelling, Campolongo, P., Thiel, M., V. Huge, M. Vogeser, Vogeser, M., CAMPOLONGO, Patrizia, I. Kaufmann, Hauer, D., A. Chouker, M. Thiel, Chouker, A., D. Hauer   +15 more
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The development and therapeutic potential of classical and next-generation cannabinoid ligands

Pharmacological Research
The endogenous cannabinoid system (ECS) is a complex network that plays a crucial role in various physiological processes, and its modulation through cannabinoid ligands has garnered significant interest in pharmacological research. Cannabinoid receptors,
Verónica Muñoz-Canales, Bellinda Benhamú, Mar Martín-Fontecha, Henar Vázquez-Villa, Silvia Ortega-Gutiérrez   +4 more
doaj   +1 more source

Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

Frontiers in Molecular Neuroscience, 2019
In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin can act as an allosteric modulator of the type 1 cannabinoid receptor (CB1R) because of its shared structural features with the ...
Robert B. Laprairie, Robert B. Laprairie, Kawthar A. Mohamed, Ayat Zagzoog, Melanie E. M. Kelly, Melanie E. M. Kelly, Lesley A. Stevenson, Roger Pertwee, Eileen M. Denovan-Wright, Ganesh A. Thakur   +9 more
doaj   +1 more source

Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor [PDF]

The cannabinoid type 2 receptor (CB2R), a G protein-coupled receptor (GPCR), is an important regulator of immune cell function and a promising target for to treat chronic inflammation and fibrosis.
Natasa, Tomasevic, Jürg, Gertsch, Christian, Becker, Christian Werner, Gruber, Jasmin, Gattringer, Simon, Hasinger, Roland, Hellinger, Fabiola Susanna, Emser, Manuel, Felkl, Peter, Keov   +9 more
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Cannabinoid modulation of cortical adrenergic receptors and transporters [PDF]

Journal of Neuroscience Research, 2009
AbstractWe previously reported that administration of the synthetic cannabinoid agonist WIN 55,212‐2 causes an increase in norepinephrine (NE) efflux in the frontal cortex (FC). The present study examined the expression levels of α2‐ and β1‐adrenergic receptors (ARs) as well as the norepinephrine transporter (NET) in the FC of rats following exposure ...
B A S, Reyes, J C, Rosario, P M T, Piana, E J, Van Bockstaele   +3 more
openaire   +2 more sources

Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R)

Frontiers in Chemistry, 2022
It is well known that G protein–coupled receptors (GPCRs) assume multiple active states. Orthosteric ligands and/or allosteric modulators can preferentially stabilize specific conformations, giving rise to pathway-biased signaling.
Rebecca Ferrisi, Francesca Gado, Francesca Gado, Beatrice Polini, Caterina Ricardi, Kawthar A. Mohamed, Lesley A. Stevenson, Gabriella Ortore, Simona Rapposelli, Giuseppe Saccomanni, Roger G. Pertwee, Robert B. Laprairie, Robert B. Laprairie, Clementina Manera, Clementina Manera, Grazia Chiellini, Grazia Chiellini   +16 more
doaj   +1 more source

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

IBRO Neuroscience Reports, 2022
Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist of 2.5–5 Hz spike-and-wave discharges (SWDs) detectable using electroencephalography (EEG).
Dan L. McElroy, Andrew J. Roebuck, Quentin Greba, Sumanta Garai, Asher L. Brandt, Orhan Yilmaz, Stuart M. Cain, Terrance P. Snutch, Ganesh A. Thakur, Robert B. Laprairie, John G. Howland   +10 more
doaj   +1 more source

An Autonomous Cannabinoid System in Islets of Langerhans

Frontiers in Endocrinology, 2021
While endocannabinoids (ECs) and cannabis were primarily studied for their nervous system effects, it is now clear that ECs are also produced in the periphery where they regulate several physiological processes, including energy storage, glucose and ...
Kanikkai Raja Aseer, Josephine M. Egan
doaj   +1 more source

Cannabinoid receptor 1 positive allosteric modulator (GAT229) attenuates cisplatin-induced neuropathic pain in mice

Saudi Pharmaceutical Journal, 2023
Chemotherapy-induced peripheral neuropathy (CIPN) is one of chemotherapies’ most often documented side effects. Patients with CIPN experience spontaneous burning, numbness, tingling, and neuropathic pain in their feet and hands.
Amina M. Bagher, Lenah S. Binmahfouz, Rasheed A. Shaik, Basma G. Eid   +3 more
doaj   +1 more source

Purification and characterization of heterologously produced cannabinoid receptor 1 and G proteins [PDF]

, 2007
G protein coupled receptors form the largest group of transmembrane proteins, which are involved in signal transduction and are targeted directly or indirectly by 40-50% of the drugs in the market.
Chillakuri, Chandramouli, Chillakuri, C.
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