Results 41 to 50 of about 6,065 (241)

Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

Frontiers in Molecular Neuroscience, 2019
In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin can act as an allosteric modulator of the type 1 cannabinoid receptor (CB1R) because of its shared structural features with the ...
Robert B. Laprairie, Robert B. Laprairie, Kawthar A. Mohamed, Ayat Zagzoog, Melanie E. M. Kelly, Melanie E. M. Kelly, Lesley A. Stevenson, Roger Pertwee, Eileen M. Denovan-Wright, Ganesh A. Thakur   +9 more
doaj   +1 more source

Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R)

Frontiers in Chemistry, 2022
It is well known that G protein–coupled receptors (GPCRs) assume multiple active states. Orthosteric ligands and/or allosteric modulators can preferentially stabilize specific conformations, giving rise to pathway-biased signaling.
Rebecca Ferrisi, Francesca Gado, Francesca Gado, Beatrice Polini, Caterina Ricardi, Kawthar A. Mohamed, Lesley A. Stevenson, Gabriella Ortore, Simona Rapposelli, Giuseppe Saccomanni, Roger G. Pertwee, Robert B. Laprairie, Robert B. Laprairie, Clementina Manera, Clementina Manera, Grazia Chiellini, Grazia Chiellini   +16 more
doaj   +1 more source

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

IBRO Neuroscience Reports, 2022
Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist of 2.5–5 Hz spike-and-wave discharges (SWDs) detectable using electroencephalography (EEG).
Dan L. McElroy, Andrew J. Roebuck, Quentin Greba, Sumanta Garai, Asher L. Brandt, Orhan Yilmaz, Stuart M. Cain, Terrance P. Snutch, Ganesh A. Thakur, Robert B. Laprairie, John G. Howland   +10 more
doaj   +1 more source

An Autonomous Cannabinoid System in Islets of Langerhans

Frontiers in Endocrinology, 2021
While endocannabinoids (ECs) and cannabis were primarily studied for their nervous system effects, it is now clear that ECs are also produced in the periphery where they regulate several physiological processes, including energy storage, glucose and ...
Kanikkai Raja Aseer, Josephine M. Egan
doaj   +1 more source

Cannabinoid receptor 1 positive allosteric modulator (GAT229) attenuates cisplatin-induced neuropathic pain in mice

Saudi Pharmaceutical Journal, 2023
Chemotherapy-induced peripheral neuropathy (CIPN) is one of chemotherapies’ most often documented side effects. Patients with CIPN experience spontaneous burning, numbness, tingling, and neuropathic pain in their feet and hands.
Amina M. Bagher, Lenah S. Binmahfouz, Rasheed A. Shaik, Basma G. Eid   +3 more
doaj   +1 more source

Putative Activation of the CB1 Cannabinoid Receptors Prevents Anxiety-Like Behavior, Oxidative Stress, and GABA Decrease in the Brain of Zebrafish Submitted to Acute Restraint Stress

Frontiers in Behavioral Neuroscience, 2021
Anxiety disorder is a well-recognized condition observed in subjects submitted to acute stress. Although the brain mechanisms underlying this disorder remain unclear, the available evidence indicates that oxidative stress and GABAergic dysfunction ...
Waldo Lucas Luz, Mateus Santos-Silva, Patrick Bruno Cardoso, Nadyme Assad, Edinaldo Rogério da Silva Moraes, Alan Barroso Araújo Grisólia, Danielle Valente Braga, Luana Ketlen Reis Leão, Suellen Alessandra Soares de Moraes, Adelaide da Conceição Passos, Evander de Jesus Oliveira Batista, Evander de Jesus Oliveira Batista, Amauri Gouveia, Karen R. H. Matos Oliveira, Anderson Manoel Herculano   +14 more
doaj   +1 more source

Endocannabinoid Release Modulates Electrical Coupling between CCK Cells Connected via Chemical and Electrical Synapses in CA1.

, 2011
Electrical coupling between some subclasses of interneurons is thought to promote coordinated firing that generates rhythmic synchronous activity in cortical regions.
Ali eAfia, Jonathan eIball, Afia B. Ali, Jonathan Iball, Iball, J, Ali, AB   +5 more
core   +1 more source

PET Radioligands for in Vivo Visualization of Neuroinflammation. [PDF]

, 2014
Neuroinflammation is a well-orchestrated, dynamic, multicellular process playing a major role in neurodegenerative disorders. The microglia which make up the innate immune system of the central nervous system are key cellular mediators of ...
Ory, Dieter, Celeb, Sofie, Celen, Sofie, Verbruggen, Alfons, Bormans, Guy   +4 more
core   +1 more source

Modulation of ATP-induced LTP by cannabinoid receptors in rat hippocampus [PDF]

Purinergic Signalling, 2012
Cannabinoids exert powerful action on various forms of synaptic plasticity. These retrograde messengers modulate GABA and glutamate release from presynaptic terminals by acting on presynaptic CB1 receptors. In particular, they inhibit long-term potentiation (LTP) elicited by electrical stimulation of excitatory pathways in rat hippocampus.
Olexandr, Ievglevskyi, Oleg, Palygin, Elena, Kondratskaya, Sergei, Grebenyuk, Oleg, Krishtal   +4 more
openaire   +2 more sources

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source