Results 41 to 50 of about 5,591 (212)

Neuroinflammation—the role of heteroreceptor complexes [PDF]

Exploration of Neuroprotective Therapy
Neuroinflammation is a hallmark of various neurodegenerative and neuropsychiatric disorders, driven by complex interactions between neurotransmitter receptors and immune signaling pathways.
Neelakanta Sarvashiva Kiran, Senthilkumar Rajagopal   +1 more
doaj   +1 more source

Non‐Invasive Brain Targeted Delivery of Cannabidiol for Alleviating Neuroinflammatory Disease

Advanced Materials, EarlyView.
The glucose‐functionalized nanoparticles (GNPs) are developed for the brain‐targeted delivery of cannabidiol (CBD). GNPs bypass the blood‐brain barrier (BBB) via glucose transporter‐1 (GLUT‐1) and release CBD in response to reactive oxygen species (ROS).
Yibin Wang, Yundong Li, Xin Wang, Yaning Hou, Wei Deng, Meng Zheng, Yan Zou, Bingyang Shi   +7 more
wiley   +1 more source

Translational potential of allosteric modulators targeting the cannabinoid CB1 receptor [PDF]

Acta Pharmacologica Sinica, 2018
The cannabinoid type-1 (CB1) receptor, a G-protein-coupled receptor, is an attractive target for drug discovery due to its involvement in many physiological processes. Historically, drug discovery efforts targeting the CB1 receptor have focused on the development of orthosteric ligands that interact with the active site to which endogenous cannabinoids
Dai, Lu, Sri Sujana, Immadi, Zhixing, Wu, Debra A, Kendall   +3 more
openaire   +2 more sources

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Overview of Novel Antipsychotic Drugs: State of the Art, New Mechanisms, and Clinical Aspects of Promising Compounds

Biomedicines
Antipsychotic medications are a vast class of drugs used for the treatment of psychotic disorders such as schizophrenia. Although numerous compounds have been developed since their introduction in the 1950s, several patients do not adequately respond to ...
Letizia Biso, Marco Carli, Marco Scarselli, Biancamaria Longoni   +3 more
doaj   +1 more source

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. [PDF]

PLoS ONE, 2009
BACKGROUND: Obesity-associated inflammation is of critical importance in the development of insulin resistance and non-alcoholic fatty liver disease.
Vanessa Deveaux, Thomas Cadoudal, Yasukatsu Ichigotani, Fatima Teixeira-Clerc, Alexandre Louvet, Sylvie Manin, Jeanne Tran-Van Nhieu, Marie Pierre Belot, Andreas Zimmer, Patrick Even, Patrice D Cani, Claude Knauf, Remy Burcelin, Adeline Bertola, Yannick Le Marchand-Brustel, Philippe Gual, Ariane Mallat, Sophie Lotersztajn   +17 more
doaj   +1 more source

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators [PDF]

Bioorganic & Medicinal Chemistry Letters, 2016
Les modulateurs allostériques négatifs (MNA) CB1 existants appartiennent à une gamme limitée de classes structurelles. Malgré le potentiel théorique des NAM CB1, les études in vivo publiées n'ont généralement pas été en mesure de démontrer les effets thérapeutiques attendus médiés par CB1.
Iain R. Greig, Gemma L. Baillie, Mostafa H. Abdelrahman, Laurent Trembleau, Ruth A. Ross   +4 more
openaire   +3 more sources

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis

Molecular Medicine, 2011
The cannabinoid system (CS) is implicated in the regulation of hepatic fibrosis, steatosis and inflammation, with cannabinoid receptors 1 and 2 (CB1 and CB2) being involved in regulation of pro- and antifibrogenic effects. Daily cannabis smoking is an independent risk factor for the progression of fibrosis in chronic hepatitis C and a mediator of ...
Patsenker, Eleonora, Stoll, Matthias, Millonig, Gunda, Agaimy, Abbas, Wissniowski, Till, Schneider, Vreni, Mueller, Sebastian, Brenneisen, Rudolf, Seitz, Helmut K., Ocker, Matthias, Stickel, Felix   +10 more
openaire   +2 more sources

Foreign Language Learning in Older Adults Modifies Resting‐State Functional Connectivity Between the Subcortical Structures and the Cortex

AGING MEDICINE, EarlyView.
Foreign language learning in older adults reorganizes thalamic and caudate connectivity, in a process topographically overlapping with the expression of receptors and genes related to neuroplasticity. ABSTRACT Objectives Neuroimaging studies suggest that Foreign Language Learning (FLL) influences resting‐state functional connectivity (rs‐FC) within the
Giovanna Bubbico, Federica Tomaiuolo, Carlo Sestieri, Golnoush Akhlaghipour, Alberto Granzotto, Antonio Ferretti, Mauro Gianni Perrucci, Stefano L. Sensi, Stefano Delli Pizzi   +8 more
wiley   +1 more source