Results 51 to 60 of about 247,667 (242)

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity

Molecules
While the opioid crisis has justifiably occupied news headlines, emergency rooms are seeing many thousands of visits for another cause: cannabinoid toxicity.
Audrey Flavin, Paniz Azizi, Natalia Murataeva, Kyle Yust, Wenwen Du, Ruth Ross, Iain Greig, Thuy Nguyen, Yanan Zhang, Ken Mackie, Alex Straiker   +10 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Modulation of Nicotinic Receptors by Cannabinoids

The FASEB Journal, 2018
The legalization of medicinal and recreational use of marijuana by many states in the USA, has resulted in an increase in its use. The two most abundant phytocannabinoids in marijuana Δ 9 ‐Tetrahydrocannabinol (THC) and cannabidiol (CBD) have been shown to have tremendous therapeutic ...
Carla Sofia Rodriguez‐Tirado, Jose Orlando Colon‐Saez, Jose Lasalde‐Dominicci   +2 more
openaire   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. [PDF]

PLoS ONE, 2009
BACKGROUND: Obesity-associated inflammation is of critical importance in the development of insulin resistance and non-alcoholic fatty liver disease.
Vanessa Deveaux, Thomas Cadoudal, Yasukatsu Ichigotani, Fatima Teixeira-Clerc, Alexandre Louvet, Sylvie Manin, Jeanne Tran-Van Nhieu, Marie Pierre Belot, Andreas Zimmer, Patrick Even, Patrice D Cani, Claude Knauf, Remy Burcelin, Adeline Bertola, Yannick Le Marchand-Brustel, Philippe Gual, Ariane Mallat, Sophie Lotersztajn   +17 more
doaj   +1 more source

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor

Medicinal research reviews (Print), 2016
The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role in many biological processes and physiological functions. A variety of CB1 receptor agonists and antagonists, including endocannabinoids, phytocannabinoids, and ...
Thuy-Ai T Nguyen, Jun-Xu Li, B. Thomas, Jenny L. Wiley, Terry Kenakin, Yanan Zhang   +5 more
semanticscholar   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Emerging therapies for the treatment of osteoporosis

Journal of Mid-Life Health, 2013
Osteoporosis is a chronic disease of the osseous system characterized by decreased bone strength and increased fracture risk. It is due to an imbalance in the dynamic ongoing processes of bone formation and bone resorption.
Garima Bhutani, Mahesh Chander Gupta
doaj   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source