Results 31 to 40 of about 6,065 (241)

Cannabinoid Receptor CB2 Modulates Axon Guidance

PLoS ONE, 2013
Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino-thalamic pathway and exerts a modulatory action on axon guidance.
Duff, Gabriel, Argaw, Anteneh, Cecyre, Bruno, Cherif, Hosni, Tea, Nicolas, Zabouri, Nawal, Casanova, Christian, Ptito, Maurice, Bouchard, Jean-François   +8 more
openaire   +5 more sources

Central cannabinoid receptors modulate acquisition of eyeblink conditioning [PDF]

Learning & Memory, 2010
Delay eyeblink conditioning is established by paired presentations of a conditioned stimulus (CS) such as a tone or light, and an unconditioned stimulus (US) that elicits the blink reflex. Conditioned stimulus information is projected from the basilar pontine nuclei to the cerebellar interpositus nucleus and cortex.
Adam B, Steinmetz, John H, Freeman
openaire   +2 more sources

Characterization of novel cannabinoid ligands and receptor-receptor interactions with a focus on the type 2 cannabinoid receptor [PDF]

, 2023
Cannabis and cannabinoids are currently being investigated for their potential utility as therapeutics in various illnesses. Of the two cannabinoid receptors that have been identified thus far, the type 2 cannabinoid receptor (CB2R) is of growing ...
Mohamed, Kawthar A
core   +1 more source

Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity

, 2020
Focusing on the importance of the free phenolic hydroxyl moiety, a family of 23 alkylresorcinol-based compounds were developed and evaluated for their cannabinoid receptor binding properties.
Marini P., Frosini M., De Petrocellis L., Boccella S., Cascio M. G., Pessina F., Manera C., Brizzi A., Luongo L., Corelli F., Mugnaini C., Maione S., Di Marzo V., Aiello F., Gado F., Ligresti A., Pertwee R. G.   +16 more
core   +2 more sources

Membrane cholesterol dependence of cannabinoid modulation of glycine receptor

The FASEB Journal, 2020
Abstract Cannabinoids exert therapeutic effects on several diseases such as chronic pain and startle disease by targeting glycine receptors (GlyRs). Our previous studies have shown that cannabinoids target a serine residue at position 296 in the third transmembrane helix of the α1/α3 GlyR.
Lei, Yao, Marta, Wells, Xiongwu, Wu, Yan, Xu, Li, Zhang, Wei, Xiong   +5 more
openaire   +3 more sources

Brain cannabinoid receptor 2: expression, function and modulation [PDF]

Acta Pharmacologica Sinica, 2017
Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of molecules, some with psychoactive effects. At least 4% of the world's adult population uses cannabis annually, making it one of the most frequently used illicit drugs in the world. The psychoactive effects of cannabis are mediated primarily through cannabinoid
De-Jie, Chen, Ming, Gao, Fen-Fei, Gao, Quan-Xi, Su, Jie, Wu   +4 more
openaire   +2 more sources

Targeting cannabinoid CB2 receptors in the Central Nervous System. Medicinal chemistry approaches with focus on neurodegenerative disorders

Frontiers in Neuroscience, 2016
Endocannabinoids activate two types of specific receptors, namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 receptors, and serious side effects of the selective antagonists of this receptor, drugs acting on CB2 ...
Gema Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franco   +5 more
doaj   +1 more source

The Endocannabinoid System and Oligodendrocytes in Health and Disease

Frontiers in Neuroscience, 2018
Cannabinoid-based interventions are being explored for central nervous system (CNS) pathologies such as neurodegeneration, demyelination, epilepsy, stroke, and trauma. As these disease states involve dysregulation of myelin integrity and/or remyelination,
Alexander A. Ilyasov, Alexander A. Ilyasov, Carolanne E. Milligan, Carolanne E. Milligan, Emily P. Pharr, Emily P. Pharr, Allyn C. Howlett, Allyn C. Howlett   +7 more
doaj   +1 more source

Cannabinoid Modulation of Memory Consolidation in Rats: Beyond the Role of Cannabinoid Receptor Subtype 1 [PDF]

Frontiers in Pharmacology, 2017
The effects induced by exogenous manipulation of endocannabinoid neurotransmission on emotion and memory are often contradictory. Among the different factors involved, of particular interest is the binding affinity of endocannabinoids, and their analogs, for other receptor families beyond cannabinoid receptors, such as the peroxisome proliferator ...
RATANO, PATRIZIA, PALMERY, Maura, Trezza, Viviana, CAMPOLONGO, Patrizia   +3 more
openaire   +3 more sources

The Cannabinoid Receptor CB1 Modulates the Signaling Properties of the Lysophosphatidylinositol Receptor GPR55 [PDF]

Journal of Biological Chemistry, 2012
The G protein-coupled receptor (GPCR) 55 (GPR55) and the cannabinoid receptor 1 (CB1R) are co-expressed in many tissues, predominantly in the central nervous system. Seven transmembrane spanning (7TM) receptors/GPCRs can form homo- and heteromers and initiate distinct signaling pathways.
Julia, Kargl, Nariman, Balenga, Gerald P, Parzmair, Andrew J, Brown, Akos, Heinemann, Maria, Waldhoer   +5 more
openaire   +2 more sources