Results 11 to 20 of about 5,591 (212)
Safe cannabinoid receptor modulators in sight? [PDF]
Nature Reviews Drug Discovery, 2012 openaire +3 more sources
Current Therapeutic Research, 2020 : Background: Structure–activity relationship studies improve the pharmacological and pharmacokinetic properties of a lead compound such as PSNCBAM-1, an allosteric modulator of the cannabinoid receptor 1.
Rachel Dopart +3 more
doaj +1 more source
Cannabinoid modulation of cortical adrenergic receptors and transporters [PDF]
Journal of Neuroscience Research, 2009 AbstractWe previously reported that administration of the synthetic cannabinoid agonist WIN 55,212‐2 causes an increase in norepinephrine (NE) efflux in the frontal cortex (FC). The present study examined the expression levels of α2‐ and β1‐adrenergic receptors (ARs) as well as the norepinephrine transporter (NET) in the FC of rats following exposure ...
B A S, Reyes +3 more
openaire +2 more sources
Frontiers in Pharmacology, 2022 Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders.
Asher L. Brandt +10 more
doaj +1 more source
Brain cannabinoid receptor 2: expression, function and modulation [PDF]
Acta Pharmacologica Sinica, 2017 Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of molecules, some with psychoactive effects. At least 4% of the world's adult population uses cannabis annually, making it one of the most frequently used illicit drugs in the world. The psychoactive effects of cannabis are mediated primarily through cannabinoid
De-Jie, Chen +4 more
openaire +2 more sources
Modulation of the cannabinoid receptors by hemopressin peptides [PDF]
Life Sciences, 2013 Changes in the endocannabinoid system are implicated in numerous diseases, making it an attractive target for pharmaceutical development. The endocannabinoid receptors have traditionally been thought to act through the effects of lipophilic messengers called cannabinoids.
Martha G, Bomar, Amit K, Galande
openaire +2 more sources
Cannabinoid Receptor CB2 Modulates Axon Guidance
PLoS ONE, 2013 Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino-thalamic pathway and exerts a modulatory action on axon guidance.
Duff, Gabriel +8 more
openaire +5 more sources
Cannabinoid receptor type-1: breaking the dogmas [version 1; referees: 3 approved]
F1000Research, 2016 The endocannabinoid system (ECS) is abundantly expressed in the brain. This system regulates a plethora of physiological functions and is composed of cannabinoid receptors, their endogenous ligands (endocannabinoids), and the enzymes involved in the ...
Arnau Busquets Garcia +3 more
doaj +1 more source
Central cannabinoid receptors modulate acquisition of eyeblink conditioning [PDF]
Learning & Memory, 2010 Delay eyeblink conditioning is established by paired presentations of a conditioned stimulus (CS) such as a tone or light, and an unconditioned stimulus (US) that elicits the blink reflex. Conditioned stimulus information is projected from the basilar pontine nuclei to the cerebellar interpositus nucleus and cortex.
Adam B, Steinmetz, John H, Freeman
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The Role of Cannabinoid Receptors in the Descending Modulation of Pain
Pharmaceuticals, 2010 The endogenous antinociceptive descending pathway represents a circuitry of the supraspinal central nervous system whose task is to counteract pain. It includes the periaqueductal grey (PAG)-rostral ventromedial medulla (RVM)-dorsal horn (DH) axis, which
Francesco Rossi +4 more
doaj +1 more source