Results 11 to 20 of about 247,667 (242)

Translational potential of allosteric modulators targeting the cannabinoid CB1 receptor

Acta Pharmacologica Sinica, 2018
Debra Kendall, Dai Lu, Sri Sujana Immadi   +2 more
exaly   +2 more sources

The Vertical and Horizontal Pathways in the Monkey Retina Are Modulated by Typical and Atypical Cannabinoid Receptors

Cells, 2021
The endocannabinoid (eCB) system has been found in all visual parts of the central ner-vous system and plays a role in the processing of visual information in many species, including monkeys and humans. Using anatomical methods, cannabinoid receptors are
Joseph Bouskila, Maxime Bleau, Catarina Micaelo-Fernandes, Jean-François Bouchard, Maurice Ptito   +4 more
doaj   +1 more source

Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2 Receptor Derived from the Natural Product Cannabidiol.

Journal of Medicinal Chemistry, 2021
Cannabidiol (CBD), the second most abundant of the active compounds found in the Cannabis sativa plant, is of increasing interest because it is approved for human use and is neither euphorizing nor addictive.
Gemma Navarro, Ángel González, Adrián Sánchez-Morales, Nil Casajuana-Martin, Marc Gómez-Ventura, A. Cordomí, F. Busqué, R. Alibés, L. Pardo, R. Franco   +9 more
semanticscholar   +1 more source

CB1 Cannabinoid Receptor Signaling and Biased Signaling

Molecules, 2021
The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration.
Luciana M. Leo, Mary E. Abood
doaj   +1 more source

Understanding the Dynamics of the Structural States of Cannabinoid Receptors and the Role of Different Modulators

Life, 2022
The cannabinoid receptors CB1R and CB2R are members of the G protein-coupled receptor (GPCR) family. These receptors have recently come to light as possible therapeutic targets for conditions affecting the central nervous system. However, because CB1R is
Anjela Manandhar, Mona H. Haron, Michael L. Klein, Khaled Elokely   +3 more
doaj   +1 more source

In Silico Prediction and Validation of CB2 Allosteric Binding Sites to Aid the Design of Allosteric Modulators

Molecules, 2022
Although the 3D structures of active and inactive cannabinoid receptors type 2 (CB2) are available, neither the X-ray crystal nor the cryo-EM structure of CB2-orthosteric ligand-modulator has been resolved, prohibiting the drug discovery and development ...
Jiayi Yuan, Chen Jiang, Junmei Wang, Chih-Jung Chen, Yixuan Hao, Guangyi Zhao, Zhiwei Feng, Xiang-Qun Xie   +7 more
doaj   +1 more source

Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1

Current Therapeutic Research, 2020
: Background: Structure–activity relationship studies improve the pharmacological and pharmacokinetic properties of a lead compound such as PSNCBAM-1, an allosteric modulator of the cannabinoid receptor 1.
Rachel Dopart, Sri Sujana Immadi, Dai Lu, Debra A. Kendall   +3 more
doaj   +1 more source

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Frontiers in Pharmacology, 2022
Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders.
Asher L. Brandt, Sumanta Garai, Ayat Zagzoog, Dow P. Hurst, Lesley A. Stevenson, Roger G. Pertwee, Gregory H. Imler, Patricia H. Reggio, Ganesh A. Thakur, Robert B. Laprairie, Robert B. Laprairie   +10 more
doaj   +1 more source

Modulation of the cannabinoid receptors by hemopressin peptides [PDF]

Life Sciences, 2013
Changes in the endocannabinoid system are implicated in numerous diseases, making it an attractive target for pharmaceutical development. The endocannabinoid receptors have traditionally been thought to act through the effects of lipophilic messengers called cannabinoids.
Martha G, Bomar, Amit K, Galande
openaire   +2 more sources

Selective Estrogen Receptor Modulators: Cannabinoid Receptor Inverse Agonists with Differential CB1 and CB2 Selectivity

Frontiers in Pharmacology, 2016
Selective estrogen receptor modulators (SERMs) are used to treat estrogen receptor (ER)-positive breast cancer and osteoporosis. Interestingly, tamoxifen and newer classes of SERMs also exhibit cytotoxic effects in cancers devoid of ERs, indicating a non-
L. Franks, Benjamin M. Ford, P. Prather
semanticscholar   +1 more source