Results 11 to 20 of about 6,065 (241)

Cholesterol as a modulator of cannabinoid receptor CB2 signaling [PDF]

Scientific Reports, 2021
Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases basal ...
Alexei Yeliseev, Malliga R. Iyer, Thomas T. Joseph, Nathan J. Coffey, Resat Cinar, Lioudmila Zoubak, George Kunos, Klaus Gawrisch   +7 more
doaj   +3 more sources

The Role of Cannabinoid Receptors in the Descending Modulation of Pain

Pharmaceuticals, 2010
The endogenous antinociceptive descending pathway represents a circuitry of the supraspinal central nervous system whose task is to counteract pain. It includes the periaqueductal grey (PAG)-rostral ventromedial medulla (RVM)-dorsal horn (DH) axis, which
Francesco Rossi, Sabatino Maione, Vito de Novellis, Livio Luongo, Enza Palazzo   +4 more
doaj   +4 more sources

Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor [PDF]

Journal of Biological Chemistry
The cannabinoid type 2 receptor (CB2R), a G protein-coupled receptor (GPCR), is an important regulator of immune cell function and a promising target for to treat chronic inflammation and fibrosis.
Natasa, Tomasevic, Jürg, Gertsch, Christian, Becker, Christian Werner, Gruber, Jasmin, Gattringer, Simon, Hasinger, Roland, Hellinger, Fabiola Susanna, Emser, Manuel, Felkl, Peter, Keov   +9 more
core   +4 more sources

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor [PDF]

Medicinal Research Reviews, 2016
The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role in many biological processes and physiological functions. A variety of CB1 receptor agonists and antagonists, including endocannabinoids, phytocannabinoids, and ...
Li, Jun‐Xu, Zhang, Yanan, Nguyen, Thuy, Wiley, Jenny L., Thomas, Brian F., Kenakin, Terry P.   +5 more
core   +3 more sources

Phytocannabinoids as Novel SGLT2 Modulators for Renal Glucose Reabsorption in Type 2 Diabetes Management [PDF]

Pharmaceuticals
Background: Sodium–glucose cotransporter 2 (SGLT2) inhibitors have transformed type 2 diabetes mellitus (T2DM) management by promoting glucosuria, lowering glycated hemoglobin (HbA1c), blood pressure, and weight; however, their use is limited by ...
Raymond Rubianto Tjandrawinata, Dante Saksono Harbuwono, Sidartawan Soegondo, Nurpudji Astuti Taslim, Fahrul Nurkolis   +4 more
doaj   +2 more sources

The Vertical and Horizontal Pathways in the Monkey Retina Are Modulated by Typical and Atypical Cannabinoid Receptors

Cells, 2021
The endocannabinoid (eCB) system has been found in all visual parts of the central ner-vous system and plays a role in the processing of visual information in many species, including monkeys and humans. Using anatomical methods, cannabinoid receptors are
Joseph Bouskila, Maxime Bleau, Catarina Micaelo-Fernandes, Jean-François Bouchard, Maurice Ptito   +4 more
doaj   +1 more source

Modulation of the cannabinoid receptors by hemopressin peptides [PDF]

Life Sciences, 2013
Changes in the endocannabinoid system are implicated in numerous diseases, making it an attractive target for pharmaceutical development. The endocannabinoid receptors have traditionally been thought to act through the effects of lipophilic messengers called cannabinoids.
Martha G, Bomar, Amit K, Galande
openaire   +2 more sources

Microglial Cannabinoid CB2 Receptors in Pain Modulation

International Journal of Molecular Sciences, 2023
Pain, especially chronic pain, can strongly affect patients’ quality of life. Cannabinoids ponhave been reported to produce potent analgesic effects in different preclinical pain models, where they primarily function as agonists of Gi/o protein-coupled cannabinoid CB1 and CB2 receptors.
Kangtai Xu, Yifei Wu, Zhuangzhuang Tian, Yuanfan Xu, Chaoran Wu, Zilong Wang   +5 more
openaire   +2 more sources

In Silico Prediction and Validation of CB2 Allosteric Binding Sites to Aid the Design of Allosteric Modulators

Molecules, 2022
Although the 3D structures of active and inactive cannabinoid receptors type 2 (CB2) are available, neither the X-ray crystal nor the cryo-EM structure of CB2-orthosteric ligand-modulator has been resolved, prohibiting the drug discovery and development ...
Jiayi Yuan, Chen Jiang, Junmei Wang, Chih-Jung Chen, Yixuan Hao, Guangyi Zhao, Zhiwei Feng, Xiang-Qun Xie   +7 more
doaj   +1 more source

Cannabinoid modulation of cortical adrenergic receptors and transporters [PDF]

Journal of Neuroscience Research, 2009
AbstractWe previously reported that administration of the synthetic cannabinoid agonist WIN 55,212‐2 causes an increase in norepinephrine (NE) efflux in the frontal cortex (FC). The present study examined the expression levels of α2‐ and β1‐adrenergic receptors (ARs) as well as the norepinephrine transporter (NET) in the FC of rats following exposure ...
B A S, Reyes, J C, Rosario, P M T, Piana, E J, Van Bockstaele   +3 more
openaire   +2 more sources