Results 21 to 30 of about 6,065 (241)

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities [PDF]

, 2018
Cannabinoid pharmacology has been intensely studied because of cannabis' pervasive medicinal and non-medicinal uses as well as for the therapeutic potential of cannabinoid-based drugs for the treatment of pain, anxiety, substance abuse, obesity, cancer ...
Piomelli, D, Kendall, D A, Khurana, L, Mackie, Ken   +3 more
core   +2 more sources

Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1

Current Therapeutic Research, 2020
: Background: Structure–activity relationship studies improve the pharmacological and pharmacokinetic properties of a lead compound such as PSNCBAM-1, an allosteric modulator of the cannabinoid receptor 1.
Rachel Dopart, Sri Sujana Immadi, Dai Lu, Debra A. Kendall   +3 more
doaj   +1 more source

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Frontiers in Pharmacology, 2022
Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders.
Asher L. Brandt, Sumanta Garai, Ayat Zagzoog, Dow P. Hurst, Lesley A. Stevenson, Roger G. Pertwee, Gregory H. Imler, Patricia H. Reggio, Ganesh A. Thakur, Robert B. Laprairie, Robert B. Laprairie   +10 more
doaj   +1 more source

Endogenous Cannabinoid Receptors Modulate Plasticity at Immature Synapses

Journal of Integrative Neuroscience, 2022
Background: To explore the mechanism of endocannabinoid cannabinoid receptor 1 (CB1) receptor pathway that regulates synaptic plasticity in the dorsal horn of the spinal cord of rats with neuropathic pain at different ages. Methods: Neonatal, juvenile, and adult male sprague dawley (SD) rats were divided into the spinal nerve preservation injury (SNI),
Jie Cheng, Xueling Chen, Hui Xia, Fanli Kong, Li Wang, Liang Zhong, Jiang Wu   +6 more
openaire   +3 more sources

Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome following Traumatic Injury: A Preliminary Report [PDF]

, 2009
The complex regional pain syndrome (CRPS) is a disabling neuropathic pain condition that may develop following injuries of the extremities. The pathogenesis of this syndrome is not clear; however, it includes complex interactions between the nervous and ...
Schelling, G., Huge, V., Kaufmann, I., G. Schelling, Campolongo, P., Thiel, M., V. Huge, M. Vogeser, Vogeser, M., CAMPOLONGO, Patrizia, I. Kaufmann, Hauer, D., A. Chouker, M. Thiel, Chouker, A., D. Hauer   +15 more
core   +1 more source

Modulation of Nicotinic Receptors by Cannabinoids

The FASEB Journal, 2018
The legalization of medicinal and recreational use of marijuana by many states in the USA, has resulted in an increase in its use. The two most abundant phytocannabinoids in marijuana Δ 9 ‐Tetrahydrocannabinol (THC) and cannabidiol (CBD) have been shown to have tremendous therapeutic ...
Carla Sofia Rodriguez‐Tirado, Jose Orlando Colon‐Saez, Jose Lasalde‐Dominicci   +2 more
openaire   +1 more source

R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids [PDF]

, 2010
Background: R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Julia Metzner, Ziebell, Simone, Koch, Marco, Myrczek, Thekla, Marian, Claudiu, Dehghani, Faramarz, Rohini Kuner, Schmidt Helmut, Bechmann Ingo, Marian Claudiu, Nina Wijnvoord, Dehghani Faramarz, Philipp Bishay, Bishay, Philipp, Kuner, Rohini, Helmut Schmidt, Faramarz Dehghani, Koch Marco, Bechmann, Ingo, Metzner, Julia, Geisslinger Gerd, Irmgard Tegeder, Tegeder Irmgard, Simone Ziebell, Wijnvoord, Nina, Tegeder, Irmgard, Claudiu Marian, Kuner Rohini, Costigan, Michael, Wijnvoord Nina, Annett Häussler, Ingo Bechmann, Michael Costigan, Schmidt, Helmut, Häussler, Annett, Bechmann, Ingo Jürgen, Myrczek Thekla, Bishay Philipp, Häussler Annett, Marco Koch, Costigan Michael, Thekla Myrczek, Metzner Julia   +45 more
core   +1 more source

Allosteric modulation of adenosine A1 and cannabinoid 1 receptor signaling by G‐peptides

Pharmacology Research & Perspectives, 2020
While allosteric modulation of GPCR signaling has gained prominence to address the need for receptor specificity, efforts have mainly focused on allosteric sites adjacent to the orthosteric ligand‐binding pocket and lipophilic molecules that target ...
Anja M. Touma, Rabia U. Malik, Tejas Gupte, Sivaraj Sivaramakrishnan   +3 more
doaj   +1 more source

The Peripheral Cannabinoid Receptor Type 1 (CB₁) as a Molecular Target for Modulating Body Weight in Man

Molecules, 2021
The cannabinoid 1 (CB1) receptor regulates appetite and body weight; however, unwanted central side effects of both agonists (in wasting disorders) or antagonists (in obesity and diabetes) have limited their therapeutic utility.
Saoirse Elizabeth O’Sullivan, Andrew S. Yates, Richard K. Porter   +2 more
doaj   +1 more source

Design of negative and positive allosteric modulators of the cannabinoid CB2 Receptor derived from the natural product cannabidiol [PDF]

, 2021
Cannabidiol (CBD), the second most abundant of the active compounds found in the Cannabis sativa plant, is of increasing interest because it is approved for human use and is neither euphorizing nor addictive.
Busqué Sánchez, Félix, Gómez-Ventura, Marc, Alibes, Ramón, Gonzalez, Angel, Navarro Brugal, Gemma, Casajuana-Martin, Nil, Pardo Carrasco, Leonardo, Sánchez-Morales, Adrià, Franco, Rafael, Cordomí Montoya, Arnau   +9 more
core   +1 more source