Results 61 to 70 of about 6,065 (241)

Efeito anti-hiperalgésico e antiinflamatório de triterpenos pentacíclicos em modelos experimentais de hiperalgesia crônica: participação do sistema canabinóide [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O presente estudo revela que o tratamento oral com os triterpenos pentacíclicos betulina (30 mg/mg ...
Silva, Kathryn Ana Bortolini Simão da
core  

Extracellular glutamate is not modulated by cannabinoid receptor activity

Scientific Reports
AbstractCannabinoid receptor activation has been proposed to trigger glutamate release from astrocytes located in cortical layer 2/3. Here, we measure the basal concentration of extracellular glutamate in layer 2/3 of mouse somatosensory cortex and find it to be 20–30 nM.
Chiu, Delia N., Carter, Brett C.
openaire   +5 more sources

Modulation of Pilocarpine-Induced Seizures by Cannabinoid Receptor 1

PLoS ONE, 2014
Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain. Endocannabinoids act at the cannabinoid CB1 receptors to reduce neurotransmitter release and the severity
Rebecca L Kow, Kelly Jiang, Alipi V Naydenov, Joshua H Le, Nephi Stella, Neil M Nathanson   +5 more
openaire   +4 more sources

Gray Matter Volume Loss in Parkinson's Disease Psychosis and Cannabinoid Receptor Gene Expression in the Brain

Movement Disorders, EarlyView.
Abstract Background Serotonergic and dopaminergic pathways are implicated in Parkinson's disease psychosis (PDP), but preliminary evidence also implicates the endocannabinoid system (ECS). Objectives We examined the association of gray matter volume loss in PDP patients with brain expression of the genes coding for CB1 (cannabinoid type 1) and CB2 ...
Sara Pisani, František Váša, Latha Velayudhan, Sagnik Bhattacharyya   +3 more
wiley   +1 more source

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. [PDF]

PLoS ONE, 2009
BACKGROUND: Obesity-associated inflammation is of critical importance in the development of insulin resistance and non-alcoholic fatty liver disease.
Vanessa Deveaux, Thomas Cadoudal, Yasukatsu Ichigotani, Fatima Teixeira-Clerc, Alexandre Louvet, Sylvie Manin, Jeanne Tran-Van Nhieu, Marie Pierre Belot, Andreas Zimmer, Patrick Even, Patrice D Cani, Claude Knauf, Remy Burcelin, Adeline Bertola, Yannick Le Marchand-Brustel, Philippe Gual, Ariane Mallat, Sophie Lotersztajn   +17 more
doaj   +1 more source

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

Nature Chemical Biology, 2019
The CB1 receptor mediates the central nervous system response to cannabinoids, and is a drug target for pain, anxiety and seizures. CB1 also responds to allosteric modulators, which influence cannabinoid binding and efficacy. To understand the mechanism of these compounds, we solved the crystal structure of CB1 with the negative allosteric modulator ...
Zhenhua Shao, Wei Yan, Karen Chapman, Karthik Ramesh, Aaron J. Ferrell, Jie Yin, Xuehui Wang, Qingping Xu, Daniel M. Rosenbaum   +8 more
openaire   +3 more sources

Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis

The Journal of Pathology, EarlyView.
Abstract Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) and the cannabinoid receptors CB1 and CB2 during AP.
Paula Goncalves‐Romeu, Karina Cárdenas‐Jaen, Enrique de‐Madaria, José María Hernández, Lourdes Fluvià, Laura Torres‐Ribas, Daniel Closa, Raquel Guillamat‐Prats   +7 more
wiley   +1 more source

Distinct Binding Mechanisms for Allosteric Sodium Ion in Cannabinoid Receptors

, 2022
The therapeutic potential of cannabinoid receptors is not fully explored due to psychoactive side effects and lack of selectivity associated with orthosteric ligands.
Diwakar Shukla, Balaji Selvam (1299327), Diwakar Shukla (195614), Balaji Selvam, Soumajit Dutta, Soumajit Dutta (11937839)   +5 more
core   +3 more sources

Emerging therapies for the treatment of osteoporosis

Journal of Mid-Life Health, 2013
Osteoporosis is a chronic disease of the osseous system characterized by decreased bone strength and increased fracture risk. It is due to an imbalance in the dynamic ongoing processes of bone formation and bone resorption.
Garima Bhutani, Mahesh Chander Gupta
doaj   +1 more source

Varenicline for cannabis use disorder: A randomized controlled trial

Addiction, EarlyView.
Abstract Background and aims Although cannabis use is widespread and prevalence of cannabis use disorder (CUD) is increasing, limited advancements have been made in CUD medication development. The objective of this study was to test the efficacy of varenicline with medical management for reducing cannabis use in treatment‐seeking individuals with CUD ...
Aimee L. McRae‐Clark, Kevin M. Gray, Nathaniel L. Baker, Brian J. Sherman, Bryan Tolliver, Jessica Burt, Alonzo Steplight, Elizabeth Chapman, Amanda Wagner   +8 more
wiley   +1 more source