Results 61 to 70 of about 247,667 (242)

Cannabinoid Receptor CB2 Modulates Axon Guidance

PLoS ONE, 2013
Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino-thalamic pathway and exerts a modulatory action on axon guidance.
Duff, Gabriel, Argaw, Anteneh, Cecyre, Bruno, Cherif, Hosni, Tea, Nicolas, Zabouri, Nawal, Casanova, Christian, Ptito, Maurice, Bouchard, Jean-François   +8 more
openaire   +5 more sources

Cannabinoid and adenosine A2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis

British Journal of Pharmacology, EarlyView.
Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues, Adam Armada‐Moreira, Laura Gómez‐Acero, Filipa F. Ribeiro, Francisco M. Mouro, Ana M. Sebastião, Francisco Ciruela, Ester Aso, Sara Xapelli   +8 more
wiley   +1 more source

Cannabinoid regulation of brain reward processing with an emphasis on the role of CB1 receptors: a step back into the future

Frontiers in Psychiatry, 2014
Over the last decades the endocannabinoid system has been implicated in a large variety of functions, including a crucial modulation of brain reward circuits and the regulation of motivational processes.
George ePanagis, Brian eMackey, Styliani eVlachou   +2 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

The role of cannabinoid ligands in neurodegenerative diseases: Emerging anti-inflammatory, immunomodulation and disease-modifying perspectives

Pharmacological Research
Neurodegenerative diseases (NDs) constitute a growing global health burden driven by population aging and remain without disease-modifying therapies.
Gabriela Mantovani Baldasso, Rodrigo Sebben Paes, Artur Graeff Moreira, Sofia Gallo Salvadori, Christian Limberger, Fiorentina Roviezzo, Rafaelle Capasso, Rafael Cypriano Dutra   +7 more
doaj   +1 more source

TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision

Cells, 2014
Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids.
Daniel A. Ryskamp, Sarah Redmon, Andrew O. Jo, David Križaj   +3 more
doaj   +1 more source

Blockade of Cannabinoid 1 Receptor Improves GLP-1R Mediated Insulin Secretion in Mice

Molecular and Cellular Endocrinology, 2015
The cannabinoid 1 receptor (CB1) is an important regulator of energy metabolism. Reports of in vivo and in vitro studies give conflicting results regarding its role in insulin secretion, possibly due to circulatory factors, such as incretins.
I. González-Mariscal, Susan M. Krzysik-Walker, Wook Kim, Michael Rouse, J. Egan   +4 more
semanticscholar   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats

BMC Genetics, 2010
Background Genetic variation in the regulatory region of the human serotonin transporter gene (SLC6A4) has been shown to affect brain functionality and personality.
Nijman Isaäc J, Homberg Judith, Kuijpers Sylvia, Cuppen Edwin   +3 more
doaj   +1 more source

Cannabinoid Receptor 2 Suppresses Leukocyte Inflammatory Migration by Modulating the JNK/c-Jun/Alox5 Pathway*

Journal of Biological Chemistry, 2013
Background: The role of cannabinoid receptor type 2 (Cnr2) in regulating immune function had been widely investigated, but the mechanism is not fully understood. Results: Cnr2 activation down-regulates 5-lipoxygenase (Alox5) expression by suppressing the
Yi-Jie Liu, Hong-Bo Fan, Yi Jin, Chunguang Ren, Xiaoe Jia, Lei Wang, Yi Chen, Mei Dong, Kang-Yong Zhu, Z. Dong, Bai-Xin Ye, Zhong Zhong, Min Deng, Tingxi Liu, R. Ren   +14 more
semanticscholar   +1 more source