Results 71 to 80 of about 6,065 (241)

Experimental Cannabinoid 2 Receptor-Mediated Immune Modulation in Sepsis [PDF]

Mediators of Inflammation, 2014
Sepsis is a complex condition that results from a dysregulated immune system in response to a systemic infection. Current treatments lack effectiveness in reducing the incidence and mortality associated with this disease. The endocannabinoid system offers great promise in managing sepsis pathogenesis due to its unique characteristics. The present study
J. Sardinha, M. E. M. Kelly, J. Zhou, C. Lehmann   +3 more
openaire   +3 more sources

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

Cannabinoid regulation of brain reward processing with an emphasis on the role of CB1 receptors: a step back into the future

Frontiers in Psychiatry, 2014
Over the last decades the endocannabinoid system has been implicated in a large variety of functions, including a crucial modulation of brain reward circuits and the regulation of motivational processes.
George ePanagis, Brian eMackey, Styliani eVlachou   +2 more
doaj   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision

Cells, 2014
Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids.
Daniel A. Ryskamp, Sarah Redmon, Andrew O. Jo, David Križaj   +3 more
doaj   +1 more source

A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding [PDF]

The Journal of Neuroscience, 2002
Recent studies suggest that the endocannabinoid system modulates feeding. Despite the existence of central mechanisms for the regulation of food intake by endocannabinoids, evidence indicates that peripheral mechanisms may also exist. To test this hypothesis, we investigated (1) the effects of feeding on intestinal anandamide accumulation; (2) the ...
Gómez, Raquel, Navarro, Miguel, Ferrer, Belén, Trigo, José M, Bilbao, Ainhoa, Del Arco, Ignacio, Cippitelli, Andrea, Nava, Felice, Piomelli, Daniele, de Fonseca, Fernando Rodrı́guez   +9 more
openaire   +4 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

The role of cannabinoid ligands in neurodegenerative diseases: Emerging anti-inflammatory, immunomodulation and disease-modifying perspectives

Pharmacological Research
Neurodegenerative diseases (NDs) constitute a growing global health burden driven by population aging and remain without disease-modifying therapies.
Gabriela Mantovani Baldasso, Rodrigo Sebben Paes, Artur Graeff Moreira, Sofia Gallo Salvadori, Christian Limberger, Fiorentina Roviezzo, Rafaelle Capasso, Rafael Cypriano Dutra   +7 more
doaj   +1 more source

Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats

BMC Genetics, 2010
Background Genetic variation in the regulatory region of the human serotonin transporter gene (SLC6A4) has been shown to affect brain functionality and personality.
Nijman Isaäc J, Homberg Judith, Kuijpers Sylvia, Cuppen Edwin   +3 more
doaj   +1 more source

Modulation of Cannabinoid Receptor Activation as a Neuroprotective Strategy for EAE and Stroke [PDF]

Journal of Neuroimmune Pharmacology, 2009
Recognition of the importance of the endocannabinoid system in both homeostasis and pathologic responses raised interest recently in the development of therapeutic agents based on this system. The CB(2) receptor, a component of the endocannabinoid system, has significant influence on immune function and inflammatory responses.
Ming, Zhang, Billy R, Martin, Martin W, Adler, Raj J, Razdan, Weimin, Kong, Doina, Ganea, Ronald F, Tuma   +6 more
openaire   +2 more sources