Results 91 to 100 of about 247,667 (242)
Structural basis for positive allosteric regulation of CB2 receptor
Nature CommunicationsThe synthetic positive allosteric modulator (PAM) of cannabinoid receptor CB2, Ec21a, exhibits better subtype selectivity and receptor specificity over orthosteric ligands, which holds promise for treating neuropathic pain and seizure without causing ...
Xuehui Wang +7 more
doaj +1 more source
The Role of Oxidative Stress in Periodontitis
Journal of Periodontal Research, EarlyView.Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon +3 more
wiley +1 more source
Straddling “The Gulf Between Medicine and Law”: Medico‐legal addiction and Japanese psychiatry
Medical Anthropology Quarterly, EarlyView.Abstract Increasing punitive drug regulations in Japan amplify longstanding tensions within psychiatric practice, pushing psychiatrists to balance clinical obligations with complex socio‐legal demands. This article analyzes how psychiatrists specializing in illicit substance use disorders to navigate escalating criminalization by developing diagnostic ...
Selim Gokce Atici
wiley +1 more source
Trichomes in Plant Defence, Development and Metabolic Integration Under Environmental Stress
Plant, Cell &Environment, EarlyView.ABSTRACT Among various plant defence strategies, trichomes are tiny hair‐like structures on the epidermis that aid in defence, environmental adaptation and the production of valuable secondary metabolites. This review features trichomes as frontline guards for plant survival, integrating their structural, physiological and metabolic roles in ...
Debdatta Chatterjee +5 more
wiley +1 more source
Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring
Experimental Physiology, EarlyView.Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas +2 more
wiley +1 more source
ASN Neuro, 2019 The contribution of glial activities to the functions, diseases, and repair of the central nervous system has received increasing attention in neuroscience studies.
Yu-Feng Wang, Yong-Jing Gao
doaj +1 more source
Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes
The Journal of Physiology, EarlyView.Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone +1 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos +7 more
wiley +1 more source
Neuroglial CB1 receptors modulate hippocampal processes in a sex-dependent manner
Biology of Sex DifferencesBackground Navigation and memory are hippocampal functions that are essential for survival. One of the key modulators of hippocampal activity is the endocannabinoid system through the cannabinoid receptor type 1 (CB1).
Jon Egaña-Huguet +14 more
doaj +1 more source