Results 91 to 100 of about 6,065 (241)
British Journal of Pharmacology, EarlyView.Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus +7 more
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Perspectives of drug treatment of obesity [PDF]
Einstein (São Paulo), 2006 The perspectives in the pharmacological treatment of obesitycan be classified in two classes: drugs already in the market,in advanced clinical trial or in final approval, or drugs in earlydevelopment.
Alfredo Halpern, Marcio C. Mancini
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British Journal of Pharmacology, EarlyView.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
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DNAThe cannabinoid receptor type 2 (CB2) is increasingly recognized as a crucial regulator of neuroimmune balance in the brain. In addition to its well-established role in immunity, the CB2 receptor has been identified in specific populations of neurons and
Hilal Kalkan, Nicolas Flamand
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, 2023 The cannabinoid receptor subtype 2 (CB2) belongs to the class A GPCR family and is an ideal therapeutic target because of its involvement in multiple diseases.
Yang, Bo
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British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
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Lipoxina A4: um modulador alostérico endocanabinóide no sistema nervoso central [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciênicas Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010Lipoxinas e endocanabinóides são eicosanóides endógenos que são liberados sob demanda em resposta à ...
Pamplona, Fabrício Alano
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The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +1 more source
Current and emerging “at-site” pain medications: a review
Journal of Pain Research, 2011 Praveen PN Rao, Tarek MohamedSchool of Pharmacy, Health Sciences Campus, University of Waterloo, Waterloo, ON, CanadaAbstract: The myriad pain pathophysiology has intrigued and challenged humanity for centuries.
Rao PPN, Mohamed T
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Fish welfare in a changing world: New developments and current challenges
Journal of Fish Biology, EarlyView.Abstract The welfare of non‐human animals is central to ethical discussions on animal use, with increasing attention to fish welfare across research, aquaria, aquaculture, and fisheries. This paper reviews current theoretical approaches to animal welfare and recent advances in defining and assessing fish welfare since the seminal paper by Huntingford ...
Sonia Rey Planellas +16 more
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