Results 101 to 110 of about 6,065 (241)

Insights into cannabinoid receptor 2 (CB2) anterograde trafficking and pharmacological chaperoning

Cellular and Molecular Life Sciences
Cannabinoid Receptor 2 (CB2) is a promising therapeutic target for modulating inflammation. Canonical signalling responses to receptor ligands are critically dependent on cell surface receptor expression.
Caitlin R. M. Oyagawa, Braden Woodhouse, Karren C. Wood, Michelle Glass, Natasha L. Grimsey   +4 more
doaj   +1 more source

Full‐Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open‐Label Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The aim of this Phase I/II open‐label study was to assess the safety and efficacy of NTI164, a novel full‐spectrum medicinal cannabis plant extract 0.08% Δ‐9‐tetrahydrocannabinol (THC), in Rett syndrome (RTT). Methods Eleven female participants (5–16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving
B. A. Keating, Y. Ogru, T. G. Duthy, L. Douglas, K. Lichkus, E. Isikgel, M. C. Fahey, C. Ellaway   +7 more
wiley   +1 more source

In silico mapping of allosteric ligand binding sites in type-1 cannabinoid receptor

, 2018
The recent resolution of the crystal structure of type-1 cannabinoid receptor (CB1 ), and the discovery of novel modulators for this target open the way to the possibility of elucidating the structural requirements for CB1 binding, and thereby facilitate
SABATUCCI, Annalaura, Mauro Maccarrone, MACCARRONE, Mauro, TORTOLANI, DANIEL, Daniel Tortolani, Annalaura Sabatucci, DAINESE, Enrico, Enrico Dainese   +7 more
core   +1 more source

Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor [PDF]

, 2017
In this work, we explored the molecular framework of the known CB1R allosteric modulator PSNCBAM-1 with the aim to generate new bioactive analogs and to deepen the structure-activity relationships of this type of compounds.
Marco Macchia, Manera, Clementina, Chiara Arena, Saccomanni, Giuseppe, Bertini, Simone, Clementina Manera, Maria Digiacomo, Mary E. Abood, Gertsch, Jürg, Abood, Mary E., Jürg Gertsch, Simone Bertini, Daniela Nieri, Abood, Mary E, Macchia, Marco, Zhao, Pingwei, Gertsch, JÃ1⁄4rg, Chicca, Andrea, Pingwei Zhao, Digiacomo, Maria, Arena, Chiara, Nieri, Daniela, Andrea Chicca, Gado, Francesca, Francesca Gado, Giuseppe Saccomanni   +25 more
core   +1 more source

Assessment of Cannabidiol Supplements Use in Small Animals Practice in Portugal

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study aimed to assess the current use of cannabidiol supplements (CBDS) by Portuguese small animal veterinary practitioners. An anonymous online survey questioning the frequency of CBDS use, purpose of use and the perceived outcome was developed using Microsoft Forms, and targeted veterinarians currently working in small animal clinics in
Maria Inês Santos, Ana Luísa Lourenço
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Design and Synthesis of Novel Cannabinoid Receptor Modulators [PDF]

, 2018
Cannabinoid (CB) receptors are validated drug targets in the endocannabinoid signaling system associated with a number of human pathologies, and the development of novel and selective small molecule CB ligands is warranted.
Thrash, Mary Paige
core  

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Cannabinoid Receptor 2 Signaling Does Not Modulate Atherogenesis in Mice

PLoS ONE, 2011
Strong evidence supports a protective role of the cannabinoid receptor 2 (CB(2)) in inflammation and atherosclerosis. However, direct proof of its involvement in lesion formation is lacking. Therefore, the present study aimed to characterize the role of the CB(2) receptor in Murine atherogenesis.Low density lipoprotein receptor-deficient (LDLR ...
Willecke, Florian, Zeschky, Katharina, Ortiz Rodriguez, Alexandra, Colberg, Christian, Auwärter, Volker, Kneisel, Stefan, Hutter, Melanie, Lozhkin, Andrey, Hoppe, Natalie, Wolf, Dennis, Zur Mühlen, Constantin von, Moser, Martin, Hilgendorf, Ingo, Bode, Christoph, Zirlik, Andreas   +14 more
openaire   +5 more sources

Straddling “The Gulf Between Medicine and Law”: Medico‐legal addiction and Japanese psychiatry

Medical Anthropology Quarterly, EarlyView.
Abstract Increasing punitive drug regulations in Japan amplify longstanding tensions within psychiatric practice, pushing psychiatrists to balance clinical obligations with complex socio‐legal demands. This article analyzes how psychiatrists specializing in illicit substance use disorders to navigate escalating criminalization by developing diagnostic ...
Selim Gokce Atici
wiley   +1 more source