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Effect of a Single Oral Dose of Dexamphetamine or Zolpidem on Attention and Reaction Time in Healthy Men

Fundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.
ABSTRACT Psychotropic medicines are known to impair cognitive function acutely, but the specific effects of individual substances remain underexplored. This study investigates the effects of dexamphetamine and zolpidem on cognitive performance to quantify the potential risk of intake and their pharmacokinetic and pharmacodynamic relationship.
Veronika Pfoser‐Poschacher +6 more
wiley +1 more source

Novel optimization of multi‐mechanistic approaches for the acute treatment of a migraine attack: A review

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1181-1192, May 2026.
Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley +1 more source

Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Microvascular dysfunction is a central determinant of organ failure in sepsis, reflecting early endothelial activation, increased permeability, and impaired capillary perfusion. Experimental evidence suggests that the endocannabinoid system (ECS) modulates these immunovascular processes, yet mechanistic insights remain dispersed across ...
Emanuel F. Matias +2 more
wiley +1 more source

Genetically Encoded CB<sub>2</sub>R-Based Fluorescent Sensor Enables Rapid Screening and Functional Assessment of Cannabinoid Modulators. [PDF]