Results 141 to 150 of about 6,065 (241)

Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice.

PLoS ONE
The cannabinoid receptor type 1 (CB1R) is a promising therapeutic target for various neurodegenerative diseases, including HIV-1-associated neurocognitive disorder (HAND).
Barkha J Yadav-Samudrala, Hailey Dodson, Shreya Ramineni, Elizabeth Kim, Justin L Poklis, Dai Lu, Bogna M Ignatowska-Jankowska, Aron H Lichtman, Sylvia Fitting   +8 more
doaj   +1 more source

Cell-free expression and molecular modeling of the γ-secretase complex and G-protein-coupled receptors

, 2013
Alzheimer’s disease (AD), which was first reported more than a century ago by Alhzeimer, is one of the commonest forms of dementia which affects >30 million people globally (>8 million in Europe).
Ghoshdastider, Umesh
core  

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, Volume 2, Issue 2, Page 309-342, June 2026.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Altered NPK Fertigation With Triacontanol Supplementation Indicates Promising Improvements to Cannabis Flower Yield and Volatile Composition

New Zealand Journal of Crop and Horticultural Science, Volume 54, Issue 2, June 2026.
Cannabis is cultivated for its flowers, which are abundant in volatile terpenes that impact sensory and therapeutic properties. These compounds are therefore targets for enhancement during cultivation. One such strategy is the provision of biostimulants, such as the long‐chain primary alcohol triacontanol (TRIA), which may be sourced from plant waxes ...
Kimber Wise, Tomer Simovich, Jamie Selby‐Pham   +2 more
wiley   +1 more source

Transcriptome assemblies for two drug‐type cannabis chemotypes by long‐read RNA sequencing

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Cannabis sativa has undergone over 10,000 years of domestication, resulting in extensive genetic and phenotypic diversity among cultivated chemotypes. Increased medical and recreational use of specialized metabolites accumulating in cannabis glandular trichomes—primarily the cannabinoids ∆9‐tetrahydrocannabinol (THC) and cannabidiol (CBD)—has ...
Oliver Berkowitz, Ricarda Jost, Sophia Ng, Antony Bacic, James Whelan, Mathew G. Lewsey   +5 more
wiley   +1 more source

Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype remain unclear. The endocannabinoid system (ECS) has emerged as a potential modulator of inflammation and tumour biology.
Gianluca Antonio Franco, Ylenia Marino, Claudia Rifici, Roberta Fusco, Davide di Paola, Salvatore Cuzzocrea, Giuseppe Catone, Cecilia Vullo, Enrico Gugliandolo   +8 more
wiley   +1 more source

Effect of environmental temperature on oxidative status, inflammatory response and endocannabinoid system at oestrus in dairy cows

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Heat stress (HS) poses a significant challenge to dairy production under climate change, as it compromises fertility, productivity and overall health in cows. This seasonal observational cross‐sectional study investigated how environmental temperature affects oxidative status, inflammatory responses and endocannabinoid system (ECS ...
Alice Carbonari, Lorenza Frattina, Matteo Burgio, Vincenzo Cicirelli, Michal Andrzej Kosior, Alessandra Sfacteria, Bianca Gasparrini, Gabriele Marino, Roberta Verde, Fabiana Piscitelli, Annalisa Rizzo   +10 more
wiley   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

The Skin and Oral Hydration Benefits of Caryophyllene Through Aquaporins 3 and 5 Type Modulation in Keratinocytes: in silico and in Vitro Research

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Objective Skin xerosis and xerostomia are partially associated with decreased expression and molecular activity of aquaporins 3 and 5 types (AQP3 and AQP5) in skin epidermal cells. While cosmetic occlusive agents and emollients are effective in improving symptoms of skin dryness, maintaining intensive water transport and physiological ...
Alina Yarovaya, Elizaveta Patronova, Egor Ilin, Viktor Filatov, Barbara de Freitas Carli, Samara Eberlin   +5 more
wiley   +1 more source

Identification of a Cannabinoid Receptor 2 Allosteric Site Using Computational Modeling and Pharmacological Analysis

Emerging evidence has demonstrated that cannabinoid receptor 2 (CB2) is involved in a number of diseases, such as neurodegenerative disorders and various types of cancer, making it an attractive pharmacological target.
McCormick, Peter J., Farooq, Zara, Farooq, Z, Iliadis, S, Contino, M, Howell, Lesley A, Iliadis, Stylianos, Mangiatordi, GF, Mangiatordi, Giuseppe Felice, McCormick, Peter J, Howell, LA, Delre, P, Contino, Marialessandra, McCormick, PJ, Delre, Pietro, Howell, Lesley A.   +15 more
core   +1 more source