Results 1 to 10 of about 355 (88)

A New Palmitoylethanolamide Form Combined with Antioxidant Molecules to Improve Its Effectivess on Neuronal Aging

Brain Sciences, 2020
Palmitoylethanolamide is a nutraceutical compound naturally produced in many plants and animal source foods, but the natural form is poorly water-soluble.
Vera Morsanuto, Rebecca Galla, Claudio Molinari   +2 more
exaly   +3 more sources

Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide?

Animals, 2021
The management of chronic pain is an integral challenge of small animal veterinary practitioners. Multiple pharmacological agents are usually employed to treat maladaptive pain including opiates, non-steroidal anti-inflammatory drugs, anticonvulsants ...
Giorgia della Rocca, Davide Gamba
doaj   +1 more source

Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention

Animals, 2021
Canine and feline cognitive dysfunction syndrome is a common neurodegenerative disorder of old age and a natural model of human Alzheimer’s disease. With the unavoidable expanding life expectancy, an increasing number of small animals will be affected ...
Caterina Scuderi, Lorenzo Golini
doaj   +1 more source

Circulating Endocannabinoids in Canine Multicentric Lymphoma Patients

Frontiers in Veterinary Science, 2022
The endocannabinoid system is increasingly being implicated in the pathogenesis and progression of various human cancers. Specifically, increased levels of 2-arachidonoylglycerol (2-AG) and oleoythanolamide (OEA) have been demonstrated in human diffuse ...
Jennifer K. Hay, Samuel E. Hocker, Samuel E. Hocker, Gabrielle Monteith, J. Paul Woods   +4 more
doaj   +1 more source

Micronized Palmitoylethanolamide, Hempseed Oil, and Maritime Pine Bark Dry Extract (Pelvipea^®) for Pelvic Pain: An In Vitro Study for Urothelial Inflammation Treatment

Cells, 2023
Urothelial inflammation plays a key role in the pathogenesis of chronic pelvic pain due to its origin in the bladder. The aim of this study was to evaluate the efficacy of a patent-pending formulation (Pelvipea®) composed of micronized ...
Alessandro Tafuri, Andrea Panunzio, Rita De Mitri, Federico Benetti, Elisa Gaio, Vincenzo Pagliarulo   +5 more
doaj   +1 more source

Antioxidant and Anti-Inflammatory Activity of Combined Phycocyanin and Palmitoylethanolamide in Human Lung and Prostate Epithelial Cells

Antioxidants, 2022
Inflammation involving the innate and adaptive immune systems is a normal response to infection; however, when allowed to continue unchecked, inflammation may result in several pathologies. Natural molecules with antioxidant properties can target the key
Loredana Bergandi, Giulia Apprato, Francesca Silvagno   +2 more
doaj   +1 more source

First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury

Biomolecules, 2022
Acute respiratory distress syndrome (ARDS) is a serious inflammatory lung disorder and a complication of SARS-CoV-2 infection. In patients with severe SARS-CoV-2 infection, the transition to ARDS is principally due to the occurrence of a cytokine storm ...
Aniello Schiano Moriello, Fiorentina Roviezzo, Fabio Arturo Iannotti, Giuseppina Rea, Marco Allarà, Rosa Camerlingo, Roberta Verde, Vincenzo Di Marzo, Stefania Petrosino   +8 more
doaj   +1 more source

An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events

Antioxidants, 2020
The inflammation process represents of a dynamic series of phenomena that manifest themselves with an intense vascular reaction. Neuroinflammation is a reply from the central nervous system (CNS) and the peripheral nervous system (PNS) to a changed ...
Marika Cordaro, Salvatore Cuzzocrea, Rosalia Crupi   +2 more
doaj   +1 more source

Co-Ultramicronized Palmitoylethanolamide/Luteolin Restores Oligodendrocyte Homeostasis via Peroxisome Proliferator-Activated Receptor-α in an In Vitro Model of Alzheimer’s Disease

Biomedicines, 2022
Oligodendrocytes are cells fundamental for brain functions as they form the myelin sheath and feed axons. They perform these critical functions thanks to the cooperation with other glial cells, mainly astrocytes.
Roberta Facchinetti, Marta Valenza, Chiara Gomiero, Giulia Federica Mancini, Luca Steardo, Patrizia Campolongo, Caterina Scuderi   +6 more
doaj   +1 more source

Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications

Biomolecules, 2022
Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic acid, is an endogenous lipid compound endowed with a plethora of pharmacological functions, including analgesic, neuroprotective, immune-modulating, and anti ...
Marta Valenza, Roberta Facchinetti, Luca Steardo, Caterina Scuderi   +3 more
doaj   +1 more source