Results 1 to 10 of about 3,153 (172)

Therapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disorders

Antioxidants
Palmitoylethanolamide (PEA) is an endocannabinoid-like bioactive lipid mediator belonging to the family of N-acylethanolamines, most abundantly found in peanuts and egg yolk. When the gastrointestinal (GI) effects of PEA are discussed, it must be pointed
Zoran Todorović, Marija Brankovic, Ivana Pantic   +2 more
exaly   +5 more sources

The Basal Pharmacology of Palmitoylethanolamide [PDF]

International Journal of Molecular Sciences, 2020
Palmitoylethanolamide (PEA, N-hexadecanoylethanolamide) is an endogenous compound belonging to the family of N-acylethanolamines. PEA has anti-inflammatory and analgesic properties and is very well tolerated in humans. In the present article, the basal pharmacology of PEA is reviewed.
Linda Rankin, Christopher Fowler, Fowler Christopher J   +2 more
exaly   +4 more sources

Effectiveness of an Oral Supplementation of Phycocyanin and Palmitoylethanolamide for a Short-Term Prophylaxis of Menstrual Migraine: A Retrospective Observational Study [PDF]

Biomedicines
Background: Menstrual migraine (MM), including pure menstrual migraine (PMM) and menstrually related migraine (MRM), is characterized by attacks occurring in close temporal association with menstruation and is often more severe, longer lasting, and less ...
Gianni Allais, Massimo Autunno, Florindo D’Onofrio, Luisa Fofi, Maria Gabriella Saracco, Fabiola Bergandi, Chiara Benedetto, Francesca Silvagno, Loredana Bergandi   +8 more
doaj   +2 more sources

An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events

Antioxidants, 2020
The inflammation process represents of a dynamic series of phenomena that manifest themselves with an intense vascular reaction. Neuroinflammation is a reply from the central nervous system (CNS) and the peripheral nervous system (PNS) to a changed ...
Salvatore Cuzzocrea, Marika Cordaro, Rosalia Crupi   +2 more
exaly   +3 more sources

Sustained Palmitoylethanolamide Infusion Restores Incentive Motivation and Synaptic Plasticity in the Tg2576 Mouse Model of Alzheimer’s Disease [PDF]

Cells
Alzheimer’s disease (AD) is increasingly recognized as a disorder not only of cognition but also of motivation and emotional regulation. Apathy and anhedonia often precede memory deficits, implicating early dysfunction in reward-related circuits.
Anna Panuccio, Zuleyha Nihan Yurtsever, Debora Cutuli, Giacomo Giacovazzo, Davide Decandia, Daniel Tortolani, Eugenia Landolfo, Sergio Oddi, Mauro Maccarrone, Laura Petrosini, Roberto Coccurello   +10 more
doaj   +2 more sources

Distinct serum endocannabinoid profiles in treatment-naïve Han Chinese children with ADHD: a case–control pilot study [PDF]

Frontiers in Neurology
ObjectiveAlthough peripheral endocannabinoid system (ECS) signatures have been implicated in ADHD among European and American populations, evidence from Asian pediatric cohorts remains scarce.
Wenjuan Liao, Xiaobin Tan, Jinhai Lin, Yuchen Wu, Qi Guo, Qucheng Huang, Longhe Yang, Yan Peng   +7 more
doaj   +2 more sources

Lactiplantibacillus sp. LP03 alleviates pulmonary fibrosis by modulating gut microbiota and elevating host palmitoylethanolamide to suppress TGF-β1/Smad2/3-mediated EMT [PDF]

Frontiers in Microbiology
IntroductionIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with limited treatment options. Emerging evidence suggests that gut microbiota dysbiosis contributes to pulmonary disorders, underscoring the therapeutic
Yuhao Zhou, Yuhao Zhou, Meina Duan, Meina Duan, Xiaoye Fan, Xiaoye Fan, Yuzhe Zhao, Yuzhe Zhao, Chao Wang, Tingting Wang, Shucheng Hua, Shucheng Hua   +11 more
doaj   +2 more sources

Therapeutic Use of Palmitoylethanolamide as an Anti-Inflammatory and Immunomodulator

Future Pharmacology, 2023
Palmitoylethanolamine (PEA) is an endocannabinoid-like compound first encountered within the lipid fractions of specific foods and has intrigued researchers since the 1950s due to its therapeutic effects.
Maria Clara Inácio de Sá, Marina Gomes Miranda Castor   +1 more
doaj   +2 more sources

Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect

Frontiers in Pharmacology, 2018
Palmitoylethanolamide (PEA) is a pleiotropic lipid mediator with established anti-inflammatory and anti-hyperalgesic activity. Ultramicronized PEA (PEA-um) has superior oral efficacy compared to naïve (non-micronized) PEA.
Salvatore Cuzzocrea, Rosalba Siracusa, Alessio Filippo Peritore   +2 more
exaly   +3 more sources

Retrospective Evaluation of L-Acetyl Carnitine and Palmitoylethanolamide as Add-On Therapy in Patients with Fibromyalgia and Small Fiber Neuropathy [PDF]

Pharmaceutics
Fibromyalgia is a complex disorder characterized by chronic widespread pain and a variety of related symptoms. Growing evidence suggests that the central and peripheral nervous systems are involved, with small fiber neuropathy playing a key role in its ...
Crescenzio Bentivenga, Arrigo Francesco Giuseppe Cicero, Federica Fogacci, Natalia Evangelia Politi, Antonio Di Micoli, Eugenio Roberto Cosentino, Paolo Gionchetti, Claudio Borghi   +7 more
doaj   +2 more sources