Results 1 to 10 of about 4,675 (154)

A New Palmitoylethanolamide Form Combined with Antioxidant Molecules to Improve Its Effectivess on Neuronal Aging [PDF]

Brain Sciences, 2020
Palmitoylethanolamide is a nutraceutical compound naturally produced in many plants and animal source foods, but the natural form is poorly water-soluble.
Francesca Uberti, Claudio Molinari, Rebecca Galla   +2 more
exaly   +5 more sources

Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide?

Animals, 2021
The management of chronic pain is an integral challenge of small animal veterinary practitioners. Multiple pharmacological agents are usually employed to treat maladaptive pain including opiates, non-steroidal anti-inflammatory drugs, anticonvulsants ...
Giorgia della Rocca, Davide Gamba
doaj   +3 more sources

Effectiveness of an Oral Supplementation of Phycocyanin and Palmitoylethanolamide for a Short-Term Prophylaxis of Menstrual Migraine: A Retrospective Observational Study. [PDF]

Biomedicines
Background: Menstrual migraine (MM), including pure menstrual migraine (PMM) and menstrually related migraine (MRM), is characterized by attacks occurring in close temporal association with menstruation and is often more severe, longer lasting, and less ...
Allais G, Autunno M, D'Onofrio F, Fofi L, Saracco MG, Bergandi F, Benedetto C, Silvagno F, Bergandi L.   +8 more
europepmc   +2 more sources

Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention [PDF]

Animals, 2021
Canine and feline cognitive dysfunction syndrome is a common neurodegenerative disorder of old age and a natural model of human Alzheimer’s disease. With the unavoidable expanding life expectancy, an increasing number of small animals will be affected ...
Caterina Scuderi, Lorenzo Golini
doaj   +3 more sources

Administration of palmitoylethanolamide in combination with topiramate in the preventive treatment of nummular headache [PDF]

International Medical Case Reports Journal, 2016
Domenico Chirchiglia,1 Attilio Della Torre,2 Francesco Signorelli,2 Giorgio Volpentesta,2 Giusy Guzzi,2 Carmelino Angelo Stroscio,2 Federica Deodato,2 Donatella Gabriele,2 Angelo Lavano,2 1Department of Neurosurgery, Neurophysiopathology Unit ...
Chirchiglia D, Della Torre A, Signorelli F, Volpentesta G, Guzzi G, Stroscio CA, Deodato F, Gabriele D, Lavano A   +8 more
doaj   +2 more sources

Sustained Palmitoylethanolamide Infusion Restores Incentive Motivation and Synaptic Plasticity in the Tg2576 Mouse Model of Alzheimer's Disease. [PDF]

Cells
Alzheimer’s disease (AD) is increasingly recognized as a disorder not only of cognition but also of motivation and emotional regulation. Apathy and anhedonia often precede memory deficits, implicating early dysfunction in reward-related circuits.
Panuccio A, Yurtsever ZN, Cutuli D, Giacovazzo G, Decandia D, Tortolani D, Landolfo E, Oddi S, Maccarrone M, Petrosini L, Coccurello R.   +10 more
europepmc   +2 more sources

Phospholipid-Based Delivery System Optimizes the Solubility and Systemic Exposure of Palmitoylethanolamide and Supports Clinical Benefits in Chronic Neuropathic Low Back Pain. [PDF]

Biomedicines
Background: Chronic neuropathic low back pain (LBP) is a prevalent health condition and difficult to treat. Conventional therapies often provide limited relief and raise safety concerns.
Khan A, Rabbani F, Kanwal A, Shafiq A, Ujjan I, Vellaccio A, Ronchi M, Petrangolini G, De Combarieu E, Turroni S, Conti G.   +10 more
europepmc   +2 more sources

Distinct serum endocannabinoid profiles in treatment-naïve Han Chinese children with ADHD: a case-control pilot study. [PDF]

Front Neurol
ObjectiveAlthough peripheral endocannabinoid system (ECS) signatures have been implicated in ADHD among European and American populations, evidence from Asian pediatric cohorts remains scarce.
Liao W, Tan X, Lin J, Wu Y, Guo Q, Huang Q, Yang L, Peng Y.   +7 more
europepmc   +2 more sources

<i>Lactiplantibacillus</i> sp. LP03 alleviates pulmonary fibrosis by modulating gut microbiota and elevating host palmitoylethanolamide to suppress TGF-β1/Smad2/3-mediated EMT. [PDF]

Front Microbiol
IntroductionIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with limited treatment options. Emerging evidence suggests that gut microbiota dysbiosis contributes to pulmonary disorders, underscoring the therapeutic
Zhou Y, Duan M, Fan X, Zhao Y, Wang C, Wang T, Hua S.   +6 more
europepmc   +2 more sources

Retrospective Evaluation of L-Acetyl Carnitine and Palmitoylethanolamide as Add-On Therapy in Patients with Fibromyalgia and Small Fiber Neuropathy. [PDF]

Pharmaceutics
Fibromyalgia is a complex disorder characterized by chronic widespread pain and a variety of related symptoms. Growing evidence suggests that the central and peripheral nervous systems are involved, with small fiber neuropathy playing a key role in its ...
Bentivenga C, Cicero AFG, Fogacci F, Politi NE, Di Micoli A, Cosentino ER, Gionchetti P, Borghi C.   +7 more
europepmc   +2 more sources