Results 21 to 30 of about 4,675 (154)

Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections [PDF]

, 2012
Background: After focal neuronal injury the endocannabinioid system becomes activated and protects or harms neurons depending on cannabinoid derivates and receptor subtypes.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Natsuo Ueda, Ueda Natsuo, Dehghani Faramarz, Faramarz Dehghani (109822), Hobusch Constance, Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Koch Marco, Geisslinger Gerd, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Natsuo Ueda (176896), Constance Hobusch, Kallendrusch Sonja, Ehrlich Angela, Kallendrusch, Sonja, Ueda, Natsuo, Marco Koch, Angela Ehrlich (109799)   +31 more
core   +2 more sources

Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats

Frontiers in Behavioral Neuroscience, 2022
Impaired gas exchange close to labor causes perinatal asphyxia (PA), a neurodevelopmental impairment factor. Palmitoylethanolamide (PEA) proved neuroprotective in experimental brain injury and neurodegeneration models.
Maria I. Herrera, Maria I. Herrera, Lucas D. Udovin, Tamara Kobiec, Tamara Kobiec, Nicolas Toro-Urrego, Carlos F. Kusnier, Rodolfo A. Kölliker-Frers, Juan P. Luaces, Matilde Otero-Losada, Francisco Capani, Francisco Capani   +11 more
doaj   +1 more source

Endocannabinoids and Human Sperm Cells

Pharmaceuticals, 2010
N-acylethanolamides (NAEs) are naturally occurring signaling lipids consisting of amides and esters of long-chain polyunsaturated fatty acids. Usually they are present in a very small amounts in many mammalian tissues and cells, including human ...
Giovanna Zolese, Annarina Ambrosini, Rosamaria Fiorini   +2 more
doaj   +1 more source

Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of Microglia

Frontiers in Neuroscience, 2019
Various studies performed in cultured cells and in in vivo models of neuronal damage showed that cannabinoids exert a neuroprotective effect. The increase in cannabinoids and cannabinoid like substances after stroke has been postulated to limit the ...
Urszula Hohmann, Markus Pelzer, Joshua Kleine, Tim Hohmann, Chalid Ghadban, Faramarz Dehghani   +5 more
doaj   +1 more source

N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation–Induced Dry Eye Syndrome

Frontiers in Pharmacology, 2020
Sleep loss is a key factor associated with dry eye. Use of a “stick over water” mouse model revealed that sleep deprivation induces accumulation of lipids, hypertrophy, and dysfunction of the lacrimal gland.
Qi Chen, Qi Chen, Qi Chen, Chunyan Ji, Chunyan Ji, Ruihe Zheng, Ruihe Zheng, Longhe Yang, Jie Ren, Jie Ren, Yitian Li, Yitian Li, Yun Han, Yun Han, Yun Han, Pan Zhou, Pan Zhou, Zuguo Liu, Zuguo Liu, Zuguo Liu, Yan Qiu, Yan Qiu, Yan Qiu   +22 more
doaj   +1 more source

Partial Reversal of Striatal Damage by Palmitoylethanolamide Administration Following Perinatal Asphyxia

Frontiers in Neuroscience, 2020
Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas.
Lucas D. Udovin, Tamara Kobiec, Tamara Kobiec, María I. Herrera, María I. Herrera, Nicolás Toro-Urrego, Carlos F. Kusnier, Rodolfo A. Kölliker-Frers, Ana B. Ramos-Hryb, Juan P. Luaces, Matilde Otero-Losada, Francisco Capani, Francisco Capani   +12 more
doaj   +1 more source

Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation [PDF]

, 2018
Objective Palmitoylethanolamide is an endogenous fatty acid mediator that is synthetized from membrane phospholipids by N-acyl phosphatidylethanolamine phospholipase D.
Raitoharju, Emma, Guillamat-Prats, Raquel, Vorst, Emiel P. C. van der, Lehtimaki, Terho, Bindila, Laura, Lyytikainen, Leo-Pekka, Rinne, Petteri, van der Vorst, Emiel P. C., Weber, Christian, Rami, Martina, Oksala, Niku, Steffens, Sabine, Ring, Larisa   +12 more
core   +1 more source

Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice

, 2001
Purpose: The purpose of this study was to evaluate in mice the antieonvulsant potential of N-palmitoylethanolamide, a putative endocannabinoid that accumulates in the body during inflammatory processes.
Vandevoorde, Séverine, Lambert, Didier D.M., Robert, Annie, Diependaele, Gérald, Govaerts, Sophie S.J.   +4 more
core   +2 more sources

Palmitoylethanolamide Ameliorates Hippocampal Damage and Behavioral Dysfunction After Perinatal Asphyxia in the Immature Rat Brain

Frontiers in Neuroscience, 2018
Perinatal asphyxia (PA) is an obstetric complication associated with an impaired gas exchange. This health problem continues to be a determinant of neonatal mortality and neurodevelopmental disorders.
María I. Herrera, María I. Herrera, Lucas D. Udovin, Nicolás Toro-Urrego, Carlos F. Kusnier, Juan P. Luaces, Francisco Capani, Francisco Capani, Francisco Capani   +8 more
doaj   +1 more source

Antioxidant and Anti-Inflammatory Activity of Combined Phycocyanin and Palmitoylethanolamide in Human Lung and Prostate Epithelial Cells

Antioxidants, 2022
Inflammation involving the innate and adaptive immune systems is a normal response to infection; however, when allowed to continue unchecked, inflammation may result in several pathologies. Natural molecules with antioxidant properties can target the key
Loredana Bergandi, Giulia Apprato, Francesca Silvagno   +2 more
doaj   +1 more source