Results 21 to 30 of about 1,588 (158)

Delay of Morphine Tolerance by Palmitoylethanolamide [PDF]

BioMed Research International, 2015
In spite of the potency and efficacy of morphine, its clinical application for chronic persistent pain is limited by the development of tolerance to the antinociceptive effect. The cellular and molecular mechanisms underlying morphine tolerance are complex and still unclear.
DI CESARE MANNELLI, LORENZO, CORTI, FRANCESCA, MICHELI, LAURA, ZANARDELLI, MATTEO, GHELARDINI, CARLA   +4 more
openaire   +2 more sources

Microglia produce and hydrolyze palmitoylethanolamide [PDF]

Neuropharmacology, 2008
Microglial cell activation and migration play an important role in neuroinflammation propagation. While it is known that the lipid transmitter palmitoylethanolamide (PEA) regulates microglial migration by interacting with a cannabinoid-like receptor, the production and inactivation of this lipid by microglia has never been addressed directly.
Giulio G, Muccioli, Nephi, Stella
openaire   +2 more sources

Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats [PDF]

, 2020
Palmitoylethanolamide is an endogenous lipid that exerts complex vascular effects, enhances the effects of endocannabinoids and induces a direct hypotension, but the mechanisms involved have been poorly explored.
González-Hernández, A. (Abimael), Ramírez-San Juan, E. (Eduardo), Maassen van den Brink, A. (Antoinette), Maassen van den Brink, Antoinette, Villalón, C.M. (Carlos), Marichal-Cancino, BA, Gonzalez-Hernandez, A, Marichal-Cancino, B.A. (Bruno), Ramirez-San Juan, E, Villalon, CM   +9 more
core   +1 more source

Effects of Palmitoylethanolamide on Aqueous Humor Outflow [PDF]

Investigative Opthalmology & Visual Science, 2012
To study the effects of palmitoylethanolamide (PEA), a fatty acid ethanolamide, on aqueous humor outflow facility.The effects of PEA on outflow facility were measured using a porcine anterior segment-perfused organ culture model. The involvements of different receptors in PEA-induced changes were investigated using receptor antagonists and adenovirus ...
Akhilesh, Kumar, Zhuanhong, Qiao, Pritesh, Kumar, Zhao-Hui, Song   +3 more
openaire   +2 more sources

Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats [PDF]

International Journal of Toxicology, 2021
Palmitoylethanolamide (PEA) is an endogenous ethanolamine playing a protective and homeodynamic role in animals and plants. Prenatal developmental toxicity of PEA was tested following oral administration to pregnant female Wistar rats, from days 0 to 19 of gestation, at dosage of 250, 500, or 1,000 mg/kg body weight, according to Organisation for ...
Narendra S. Deshmukh, Shailesh Gumaste, Silma Subah, Nathasha Omal Bogoda   +3 more
openaire   +2 more sources

Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections [PDF]

, 2012
Background: After focal neuronal injury the endocannabinioid system becomes activated and protects or harms neurons depending on cannabinoid derivates and receptor subtypes.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Natsuo Ueda, Ueda Natsuo, Dehghani Faramarz, Faramarz Dehghani (109822), Hobusch Constance, Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Koch Marco, Geisslinger Gerd, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Natsuo Ueda (176896), Constance Hobusch, Kallendrusch Sonja, Ehrlich Angela, Kallendrusch, Sonja, Ueda, Natsuo, Marco Koch, Angela Ehrlich (109799)   +31 more
core   +1 more source

Oral Adelmidrol Administration Up-Regulates Palmitoylethanolamide Production in Mice Colon and Duodenum through a PPAR-γ Independent Action

Metabolites, 2022
Adelmidrol is a promising palmitoylethanolamide (PEA) analog which displayed up-and-coming anti-inflammatory properties in several inflammatory conditions.
Alessandro Del Re, Irene Palenca, Luisa Seguella, Marcella Pesce, Chiara Corpetti, Luca Steardo, Sara Rurgo, Giovanni Sarnelli, Giuseppe Esposito   +8 more
doaj   +1 more source

Palmitoylethanolamide for Neurological Disorders [PDF]

OBM Neurobiology, 2020
Neurological tissue along with the cartilage remains one of the tissues that escapes human efforts of regeneration after injury. The human body, after an injury, can repair its tissues only to a certain extent that can help in recovering the function of organs. However, this is not the case in some organs, such as the brain and spinal cord.
openaire   +1 more source

Questioning the Role of Palmitoylethanolamide in Psychosis: A Systematic Review of Clinical and Preclinical Evidence

, 2023
This review aims at gathering and discussing all available data from clinical and preclinical evidence regarding the role of palmitoylethanolamide (PEA) in psychosis and related conditions by conducting a systematic literature search for all such ...
Riccardo Bortoletto, Marco Colizzi
core   +4 more sources

Palmitoylethanolamide Mitigates Paclitaxel Toxicity in Primary Dorsal Root Ganglion Neurons

Biomolecules, 2022
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of several chemotherapeutic agents, such as Paclitaxel. The main symptoms of CIPN are pain and numbness in the hands and feet.
Amira Elfarnawany, Faramarz Dehghani
doaj   +1 more source