Results 1 to 10 of about 31,825 (224)

Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis

Frontiers in Pharmacology, 2023
Introduction: Luteolin inhibits platelet activation and thrombus formation, but the mechanisms are unclear. This study investigated the effects of luteolin on GPVI-mediated platelet activation in vitro and explored the effect of luteolin on thrombosis ...
Yujia Ye, Lihong Yang, Min Leng, Qian Wang, Jiankui Wu, Wen Wan, Huawei Wang, Longjun Li, Yunzhu Peng, Shengjie Chai, Zhaohui Meng   +10 more
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Improving water dispersibility and bioavailability of luteolin using microemulsion system

Scientific Reports, 2022
We have studied the physiological effects and health functions of luteolin, especially focusing on its absorption and metabolism. Recent studies have reported the advantages of microemulsion to improve the bioavailability of poorly water-soluble ...
Ayaka Miyashita, Junya Ito, Isabella Supardi Parida, Naoki Syoji, Tomoyuki Fujii, Hidehiro Takahashi, Kiyotaka Nakagawa   +6 more
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Luteolin alleviates inflammation and autophagy of hippocampus induced by cerebral ischemia/reperfusion by activating PPAR gamma in rats

BMC Complementary Medicine and Therapies, 2022
Background Luteolin, a flavonoid compound with anti-inflammatory activity, has been reported to alleviate cerebral ischemia/reperfusion (I/R) injury. However, its potential mechanism remains unclear. Methods The binding activity of luteolin to peroxisome
Lu Li, Guanghua Pan, Rong Fan, Dalei Li, Lei Guo, Lili Ma, Hui Liang, Jiaoxue Qiu   +7 more
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Luteolin Modulates Neural Stem Cells Fate Determination: In vitro Study on Human Neural Stem Cells, and in vivo Study on LPS-Induced Depression Mice Model

Frontiers in Cell and Developmental Biology, 2021
Luteolin is a natural flavone with neurotrophic effects observed on different neuronal cell lines. In the present study, we aimed to assess the effect of luteolin on hNSCs fate determination and the LPS-induced neuroinflammation in a mouse model of ...
Mariem Achour, Mariem Achour, Farhana Ferdousi, Farhana Ferdousi, Farhana Ferdousi, Kazunori Sasaki, Kazunori Sasaki, Hiroko Isoda, Hiroko Isoda, Hiroko Isoda   +9 more
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Biosynthesis of a water solubility‐enhanced succinyl glucoside derivative of luteolin and its neuroprotective effect

Microbial Biotechnology, 2022
Summary The natural flavonoids luteolin and luteoloside have anti‐bacterial, anti‐inflammatory, anti‐oxidant, anti‐tumour, hypolipidemic, cholesterol lowering and neuroprotective effects, but their poor water solubility limits their application in ...
Liangliang Chen, Siyuan Chang, Lin Zhao, Bingfeng Li, Sen Zhang, Chenke Yun, Xiao Wu, Jingyi Meng, Guoqing Li, Sheng Guo, Jinao Duan   +10 more
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Mechanism and Experimental Verification of Luteolin for the Treatment of Osteoporosis Based on Network Pharmacology

Frontiers in Endocrinology, 2022
PurposeTo explore the molecular mechanism of luteolin in the treatment of osteoporosis (OP) by network pharmacological prediction and experimentation.MethodsThe target proteins of luteolin were obtained with the Traditional Chinese Medicine Systems ...
Guihong Liang, Guihong Liang, Jinlong Zhao, Yaoxing Dou, Yaoxing Dou, Yuan Yang, Yuan Yang, Di Zhao, Zhanpeng Zhou, Rui Zhang, Weiyi Yang, Lingfeng Zeng, Lingfeng Zeng   +12 more
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Improving the anticancer efficiency of doxorubicin by luteolin nanoemulsion: In vitro study [PDF]

Nanomedicine Journal, 2023
Objective(s): Recently, medicinal plants have grabbed much attention in the prevention and treatment of cancer due to their ability to increase the efficiency of chemotherapy agents.
Nooshin Divanbeigi, Mozhdeh Yousefian, Leila Etemad, Majid Azizi, Ailin Ebrahimzadeh, Fatemeh Oroojalian, Maryam Hashemi   +6 more
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Protective effects of luteolin on injury induced inflammation through reduction of tissue uric acid and pro-inflammatory cytokines in rats

Journal of Traditional and Complementary Medicine, 2020
Background and aim: Luteolin belongs to flavone group of flavonoids, present in many plants with potent antioxidant, anti-inflammatory and anti-proliferative effects.
Santram Lodhi, Gautam P. Vadnere, Kiran D. Patil, Tushar P. Patil   +3 more
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Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. [PDF]

PLoS ONE, 2012
Angiogenesis, the formation of new blood vessels from pre-existing vascular beds, is essential for tumor growth, invasion, and metastasis. Luteolin is a common dietary flavonoid found in fruits and vegetables.
Poyil Pratheeshkumar, Young-Ok Son, Amit Budhraja, Xin Wang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Donghern Kim, Sasidharan Padmaja Divya, Gang Chen, Zhuo Zhang, Jia Luo, Xianglin Shi   +13 more
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Luteolin Ameliorates Experimental Pulmonary Arterial Hypertension via Suppressing Hippo-YAP/PI3K/AKT Signaling Pathway

Frontiers in Pharmacology, 2021
Luteolin is a flavonoid compound with a variety of pharmacological effects. In this study, we explored the effects of luteolin on monocrotaline (MCT) induced rat pulmonary arterial hypertension (PAH) and underlying mechanisms.
Wanyun Zuo, Na Liu, Yunhong Zeng, Zhenghui Xiao, Keke Wu, Fan Yang, Biao Li, Qingqing Song, Yunbin Xiao, Qiming Liu   +9 more
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