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Potential Efficacy of Luteolin in Cutaneous Squamous Cell Carcinoma: A Combined In Vitro and In Vivo Study [PDF]
BiomoleculesCutaneous squamous cell carcinoma (cSCC) is a common malignant skin tumor with invasive potential and risk of recurrence. This study investigated the anti-cSCC effects of luteolin in vitro and in vivo and explored the associated molecular mechanisms. The
Yuyang Guo +8 more
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Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis
Frontiers in Pharmacology, 2023 Introduction: Luteolin inhibits platelet activation and thrombus formation, but the mechanisms are unclear. This study investigated the effects of luteolin on GPVI-mediated platelet activation in vitro and explored the effect of luteolin on thrombosis ...
Yujia Ye +10 more
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Improving water dispersibility and bioavailability of luteolin using microemulsion system
Scientific Reports, 2022 We have studied the physiological effects and health functions of luteolin, especially focusing on its absorption and metabolism. Recent studies have reported the advantages of microemulsion to improve the bioavailability of poorly water-soluble ...
Ayaka Miyashita +6 more
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BMC Complementary Medicine and Therapies, 2022 Background Luteolin, a flavonoid compound with anti-inflammatory activity, has been reported to alleviate cerebral ischemia/reperfusion (I/R) injury. However, its potential mechanism remains unclear. Methods The binding activity of luteolin to peroxisome
Lu Li +7 more
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Frontiers in Cell and Developmental Biology, 2021 Luteolin is a natural flavone with neurotrophic effects observed on different neuronal cell lines. In the present study, we aimed to assess the effect of luteolin on hNSCs fate determination and the LPS-induced neuroinflammation in a mouse model of ...
Mariem Achour +9 more
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Microbial Biotechnology, 2022 Summary The natural flavonoids luteolin and luteoloside have anti‐bacterial, anti‐inflammatory, anti‐oxidant, anti‐tumour, hypolipidemic, cholesterol lowering and neuroprotective effects, but their poor water solubility limits their application in ...
Liangliang Chen +10 more
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Frontiers in Endocrinology, 2022 PurposeTo explore the molecular mechanism of luteolin in the treatment of osteoporosis (OP) by network pharmacological prediction and experimentation.MethodsThe target proteins of luteolin were obtained with the Traditional Chinese Medicine Systems ...
Guihong Liang +12 more
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Improving the anticancer efficiency of doxorubicin by luteolin nanoemulsion: In vitro study [PDF]
Nanomedicine Journal, 2023 Objective(s): Recently, medicinal plants have grabbed much attention in the prevention and treatment of cancer due to their ability to increase the efficiency of chemotherapy agents.
Nooshin Divanbeigi +6 more
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Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. [PDF]
PLoS ONE, 2012 Angiogenesis, the formation of new blood vessels from pre-existing vascular beds, is essential for tumor growth, invasion, and metastasis. Luteolin is a common dietary flavonoid found in fruits and vegetables.
Poyil Pratheeshkumar +13 more
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Role of Luteolin-Induced Apoptosis and Autophagy in Human Glioblastoma Cell Lines
Medicina, 2021 Background and Objectives: Malignant glioblastoma (GBM) is caused by abnormal proliferation of glial cells, which are found in the brain. The therapeutic effects of surgical treatment, radiation therapy, and chemo-therapy against GBM are relatively poor ...
Hye-Sung Lee +5 more
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