Results 11 to 20 of about 1,588 (158)

Phytotherapics in COVID19: Why palmitoylethanolamide? [PDF]

Phytotherapy Research, 2020
At present, googling the search terms “COVID‐19” and “Functional foods” yields nearly 500,000,000 hits, witnessing the growing interest of the scientific community and the general public in the role of nutrition and nutraceuticals during the COVID‐19 pandemic.
Pesce M., Seguella L., Cassarano S., Aurino L., Sanseverino W., Lu J., Corpetti C., Del Re A., Vincenzi M., Sarnelli G., Esposito G.   +10 more
core   +6 more sources

Palmitoylethanolamide: A Natural Compound for Health Management [PDF]

International Journal of Molecular Sciences, 2021
All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders.
Clayton, Paul, Hill, Mariko, Bogoda, Nathasha, Subah, Silma, Venkatesh, Ruchitha   +4 more
openaire   +3 more sources

Therapeutic Use of Palmitoylethanolamide as an Anti-Inflammatory and Immunomodulator

Future Pharmacology, 2023
Palmitoylethanolamine (PEA) is an endocannabinoid-like compound first encountered within the lipid fractions of specific foods and has intrigued researchers since the 1950s due to its therapeutic effects.
Maria Clara Inácio de Sá, Marina Gomes Miranda Castor   +1 more
doaj   +2 more sources

Administration of palmitoylethanolamide in combination with topiramate in the preventive treatment of nummular headache [PDF]

International Medical Case Reports Journal, 2016
Domenico Chirchiglia,1 Attilio Della Torre,2 Francesco Signorelli,2 Giorgio Volpentesta,2 Giusy Guzzi,2 Carmelino Angelo Stroscio,2 Federica Deodato,2 Donatella Gabriele,2 Angelo Lavano,2 1Department of Neurosurgery, Neurophysiopathology Unit ...
Chirchiglia D, Della Torre A, Signorelli F, Volpentesta G, Guzzi G, Stroscio CA, Deodato F, Gabriele D, Lavano A   +8 more
doaj   +2 more sources

Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders

Biomolecules, 2022
Increasing evidence strongly supports the key role of neuroinflammation in the pathophysiology of neurodegenerative diseases, such as Alzheimer’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Neuroinflammation may alter synaptic transmission contributing to the progression of neurodegeneration, as largely documented in animal ...
Assogna M., Di Lorenzo F., Martorana A., Koch G.   +3 more
openaire   +7 more sources

Therapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disorders

Antioxidants
Palmitoylethanolamide (PEA) is an endocannabinoid-like bioactive lipid mediator belonging to the family of N-acylethanolamines, most abundantly found in peanuts and egg yolk. When the gastrointestinal (GI) effects of PEA are discussed, it must be pointed
Marija Branković, Tijana Gmizić, Marija Dukić, Marija Zdravković, Branislava Daskalović, Davor Mrda, Novica Nikolić, Milica Brajković, Milan Gojgić, Jovana Lalatović, Đorđe Kralj, Ivana Pantić, Marko Vojnović, Tamara Milovanović, Siniša Đurašević, Zoran Todorović   +15 more
doaj   +3 more sources

Harnessing the anti-inflammatory potential of palmitoylethanolamide

Drug Discovery Today, 2014
Palmitoylethanolamide (PEA) is a peroxisome proliferator-activated receptor alpha (PPAR-α) ligand that exerts anti-inflammatory, analgesic and neuroprotective actions. PEA is synthetized from phospholipids through the sequential actions of N-acyltransferase and N-acylphosphatidylethanolamine-preferring phospholipase D (NAPE-PLD), and its actions are ...
Mireille, Alhouayek, Giulio G, Muccioli
openaire   +3 more sources

Palmitoylethanolamide: A Potential Alternative to Cannabidiol [PDF]

Journal of Dietary Supplements, 2021
The endocannabinoid system (ECS) is a widespread cell signaling network that maintains homeostasis in response to endogenous and exogenous stressors. This has made the ECS an attractive therapeutic target for various disease states. The ECS is a well-known target of exogenous phytocannabinoids derived from cannabis plants, the most well characterized ...
Paul, Clayton, Silma, Subah, Ruchitha, Venkatesh, Mariko, Hill, Nathasha, Bogoda   +4 more
openaire   +2 more sources

The Basal Pharmacology of Palmitoylethanolamide [PDF]

International Journal of Molecular Sciences, 2020
Palmitoylethanolamide (PEA, N-hexadecanoylethanolamide) is an endogenous compound belonging to the family of N-acylethanolamines. PEA has anti-inflammatory and analgesic properties and is very well tolerated in humans. In the present article, the basal pharmacology of PEA is reviewed.
Linda Rankin, Christopher J. Fowler
openaire   +3 more sources

Palmitoylethanolamide gels edible oils

Food Chemistry, 2022
Palmitoylethanolamide (PEA) is an endogenous compound with no adverse effect for oral intakes of a gram per day. We show that PEA gels edible oils at concentrations as low as 0.5 wt%. The elastic moduli values of the formed gels are 1400 Pa at 1 wt% and 9000 Pa at 2 wt%. The study of the gels by cryo-SEM, optical microscopy and WAXS show that PEA forms
Schwaller, Duncan, Sui, Yi, Carvalho, Alain, Collin, Dominique, Mésini, Philippe   +4 more
openaire   +3 more sources