Results 31 to 40 of about 4,675 (154)

Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranes.

, 2023
BackgroundHuman amniotic and amniochorionic membranes (AM, ACM) represent the most often used grafts accelerating wound healing. Palmitoylethanolamide, oleoylethanolamide and anandamide are endogenous bioactive lipid molecules, generally referred as N ...
Alzbeta Svobodova, Ingrida Smeringaiova, Katerina Jirsova, Vladimir Vrkoslav   +3 more
core   +1 more source

First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury

Biomolecules, 2022
Acute respiratory distress syndrome (ARDS) is a serious inflammatory lung disorder and a complication of SARS-CoV-2 infection. In patients with severe SARS-CoV-2 infection, the transition to ARDS is principally due to the occurrence of a cytokine storm ...
Aniello Schiano Moriello, Fiorentina Roviezzo, Fabio Arturo Iannotti, Giuseppina Rea, Marco Allarà, Rosa Camerlingo, Roberta Verde, Vincenzo Di Marzo, Stefania Petrosino   +8 more
doaj   +1 more source

Co-Ultramicronized Palmitoylethanolamide/Luteolin Restores Oligodendrocyte Homeostasis via Peroxisome Proliferator-Activated Receptor-α in an In Vitro Model of Alzheimer’s Disease

Biomedicines, 2022
Oligodendrocytes are cells fundamental for brain functions as they form the myelin sheath and feed axons. They perform these critical functions thanks to the cooperation with other glial cells, mainly astrocytes.
Roberta Facchinetti, Marta Valenza, Chiara Gomiero, Giulia Federica Mancini, Luca Steardo, Patrizia Campolongo, Caterina Scuderi   +6 more
doaj   +1 more source

Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications

Biomolecules, 2022
Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic acid, is an endogenous lipid compound endowed with a plethora of pharmacological functions, including analgesic, neuroprotective, immune-modulating, and anti ...
Marta Valenza, Roberta Facchinetti, Luca Steardo, Caterina Scuderi   +3 more
doaj   +1 more source

Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo

, 2016
N-Palmitoylethanolamide showed great therapeutic potential in the treatment of inflammation and pain but its unfavourable pharmacokinetics properties will hinder its use in the clinical practice.
Ostacolo, Carmine, Russo, Roberto, Calignano, Antonio, Offerta, Alessia, Puglia, Carmelo, De Caro, Carmen, Tronino, Diana, BLASI, Paolo   +7 more
core   +2 more sources

Oral Adelmidrol Administration Up-Regulates Palmitoylethanolamide Production in Mice Colon and Duodenum through a PPAR-γ Independent Action

Metabolites, 2022
Adelmidrol is a promising palmitoylethanolamide (PEA) analog which displayed up-and-coming anti-inflammatory properties in several inflammatory conditions.
Alessandro Del Re, Irene Palenca, Luisa Seguella, Marcella Pesce, Chiara Corpetti, Luca Steardo, Sara Rurgo, Giovanni Sarnelli, Giuseppe Esposito   +8 more
doaj   +1 more source

Protective effect of palmitoylethanolamide, a naturally-occurring molecule, in a rat model of cystitis

, 2014
PURPOSE: Palmitoylethanolamide is both an endogenous mediator released together with the endocannabinoid anandamide from membrane phospholipids, and a plant-derived compound with analgesic and antinflammatory properties.
Di Marzo V, Valacchi G, Borrelli F, Pessina F, Capasso R, Aveta T, Orlando P, Izzo AA, Buono L, Fiorenzani P   +9 more
core   +1 more source

Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy

Frontiers in Molecular Neuroscience, 2018
Research on the antiepileptic effects of (endo-)cannabinoids has remarkably progressed in the years following the discovery of fundamental role of the endocannabinoid (eCB) system in controlling neural excitability. Moreover, an increasing number of well-
Julia M. Post, Sebastian Loch, Raissa Lerner, Floortje Remmers, Ermelinda Lomazzo, Beat Lutz, Laura Bindila   +6 more
doaj   +1 more source

Palmitoylethanolamide Mitigates Paclitaxel Toxicity in Primary Dorsal Root Ganglion Neurons

Biomolecules, 2022
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of several chemotherapeutic agents, such as Paclitaxel. The main symptoms of CIPN are pain and numbness in the hands and feet.
Amira Elfarnawany, Faramarz Dehghani
doaj   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source