Results 51 to 60 of about 3,153 (172)

Palmitoylethanolamide Mitigates Paclitaxel Toxicity in Primary Dorsal Root Ganglion Neurons

Biomolecules, 2022
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of several chemotherapeutic agents, such as Paclitaxel. The main symptoms of CIPN are pain and numbness in the hands and feet.
Amira Elfarnawany, Faramarz Dehghani
doaj   +1 more source

Effect of transcutaneous electrical nerve stimulation on physical activity and pain evaluation in osteoarthritic dogs

Veterinary Record, EarlyView.
Abstract Background Osteoarthritis (OA) causes chronic pain and reduces welfare in dogs. Standard treatments may be inadequate or associated with adverse effects, prompting investigation of alternative therapies. Transcutaneous electrical nerve stimulation (TENS) is a non‐pharmacological pain management method, but evidence for its efficacy in canine ...
Anja Pedersen, Johanna Penell, Emil Olsen, Heli Hyytiäinen, Franck Forterre, Anna Bergh   +5 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Palmitoylethanolamide in the Treatment of Failed Back Surgery Syndrome [PDF]

Pain Research and Treatment, 2017
Introduction. This observational study was designed to evaluate the efficacy of ultramicronized palmitoylethanolamide (um-PEA) (Normast®) administration, as add-on therapy for chronic pain, in the management of pain-resistant patients affected by failed back surgery syndrome. Methods.
PALADINI, ANTONELLA, VARRASSI, Giustino, Bentivegna, Giuseppe, Carletti, Sandro, PIROLI, ALBA, Coaccioli, Stefano   +5 more
openaire   +2 more sources

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

Frontiers in Physiology, 2017
Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental health effects, shadowing its multiple crucial physiological activities.
Gianfranca Carta, Elisabetta Murru, Sebastiano Banni, Claudia Manca   +3 more
doaj   +1 more source

Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2016
Chemotherapy-induced peripheral neuropathy (CIPN) represents a serious complication associated with antineoplastic drugs. Although there are no medications available that effectively prevent CIPN, many classes of drugs have been used to treat this condition, including anticonvulsants, serotonin and noradrenaline reuptake inhibitors, and opioids ...
Giulia, Donvito, Jenny L, Wilkerson, M Imad, Damaj, Aron H, Lichtman   +3 more
openaire   +2 more sources

Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Sebastiaan Dalle, Kaat Vanderbeke, Thibaut Burg, Moniek Schouten, Wout Lauriks, Nicole Hersmus, Ludo Van Den Bosch, Katrien Koppo   +7 more
wiley   +1 more source

Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis

The Journal of Pathology, Volume 269, Issue 4-5, Page 462-477, August 2026.
Abstract Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) and the cannabinoid receptors CB1 and CB2 during AP.
Paula Goncalves‐Romeu, Karina Cárdenas‐Jaen, Enrique de‐Madaria, José María Hernández, Lourdes Fluvià, Laura Torres‐Ribas, Daniel Closa, Raquel Guillamat‐Prats   +7 more
wiley   +1 more source

Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-Inflammation

Pharmaceutics
Palmitoylethanolamide (PEA) exhibits multiple skincare functions such as anti-nociceptive and anti-inflammatory effects. However, its topical application is limited due to its difficulty in bypassing the stratum corneum barrier, relatively low ...
Chuanpeng Ren, Yanyun Ma, Yizhen Wang, Dan Luo, Yanhan Hong, Xinyuan Zhang, Hexiang Mei, Wei Liu   +7 more
doaj   +1 more source