Results 71 to 80 of about 4,675 (154)

Unique/Rapid Feedback Mechanisms of PGD2 and PGE2 as Local/Short‐Lived Autacoids; Implications of Biased Activities by Their Metabolites

BioEssays, Volume 48, Issue 7, July 2026.
Since autacoids are short‐lived bioactive substances that act near their site of biosynthesis, the biased activities of prostanoid metabolites may have significant physiological implications with regard to the newly defined and/or re‐acknowledged as unique and novel nongenomic feedback mechanisms, which may be one of very important roles of prostanoids
Hiromichi Fujino, Keijo Fukushima
wiley   +1 more source

Clinical applications of Palmitoylethanolamide in pain management: protocol for a scoping review

, 2019
Protocol of a scoping review focusing on applications of the Palmitoylethanolamide in the chronic pain management and its ...
Sveva Di Franco, Marco Fiore
core   +1 more source

Reprogramming lipid metabolism for cognitive restoration in Alzheimer's via PLA2G4E

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION Growing evidence implicates dysregulated brain lipid metabolism in Alzheimer's disease (AD) pathogenesis, influencing membrane integrity, neuroinflammation, and amyloid beta and tau pathology, thereby representing a promising therapeutic target.
Sara Badesso, María Espelosín, Cristina Alonso, Alejandro Montilla, Maria Collantes, Mar Cuadrado‐Tejedor, Ana García‐Osta   +6 more
wiley   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Add-on administration of ultramicronized palmitoylethanolamide in the treatment of new-onset burning mouth syndrome

, 2019
Domenico Chirchiglia,1 Pasquale Chirchiglia,1 Rosa Marotta,2 Luca Gallelli3 1Department of Neurosurgery, University of Catanzaro, Campus Germaneto, Catanzaro 88100, Italy; 2Department of Medical-Surgical Sciences, University of Catanzaro, Campus ...
Gallelli L, Marotta R, Chirchiglia D, Chirchiglia P   +3 more
core  

Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors

, 1999
peer reviewedThe presence of CB(2) receptors was reported in the rat basophilic cell line RBL-2H3 and N-palmitoylethanolamide was proposed as an endogenous, potent agonist of this receptor. We synthesized a series of 10 N-palmitoylethanolamide homologues
Delzenne, Nathalie M., Tschirhart, Eric J., DiPaolo, F. G., Sonveaux, Pierre, Hermans, E., Lambert, Didier, DiPaolo, Federica G., Lambert, D. M., Sonveaux, P., Govaerts, S. J., Kanyonyo, Martial, Hermans, Emmanuel, BUEB, Jean-Luc, Delzenne, N. M., Govaerts, Sophie, Kanyonyo, M., TSCHIRHART, Eric   +16 more
core   +1 more source

Polydatin Inhibits Neuroinflammation in Cerebral Ischemia–Reperfusion Injury Through Suppressing the CXCL3/CXCR2 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
PD can act on the CXCL3/CXCR2 axis, thereby inhibiting migration and activation of microglia and neutrophils, and thus alleviating the inflammatory response associated with CIRI, highlighting its potential as a therapeutic agent for CIRI. ABSTRACT Aim The aim of this study is to investigate the precise mechanisms by which Polydatin (PD) ameliorates ...
Youxiang Cui, Fangmei Hu, Shixin Wang, Zehua Liu, Jinzhou Chen, Mingyue Cui, Leilei Wang, Yuming Wang, Ning Wang, Yuhong Bian, Shuquan Lv, Huantian Cui   +11 more
wiley   +1 more source

Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome

, 2015
Jan M Keppel Hesselink, David J Kopsky Institute for Neuropathic Pain, Bosch en Duin, the NetherlandsAbstract: Palmitoylethanolamide (PEA) is an endogenous lipid modulator in animals and humans, and has been evaluated since the 1970s as an anti ...
Kopsky DJ, Keppel Hesselink JM
core  

Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trial

Frontiers in Nutrition
IntroductionMigraines are neurological disorders which significantly impact quality of life. Current pharmacological treatments often have adverse effects, prompting the search for alternatives with fewer side effects.
Vincenzo Piccolo, Adua Marzocchi, Maria Maisto, Vincenzo Summa, Gian Carlo Tenore, Angela Amoresano, Angela Amoresano   +6 more
doaj   +1 more source