Results 71 to 80 of about 1,588 (158)

Distinct serum endocannabinoid profiles in treatment-naïve Han Chinese children with ADHD: a case–control pilot study

Frontiers in Neurology
ObjectiveAlthough peripheral endocannabinoid system (ECS) signatures have been implicated in ADHD among European and American populations, evidence from Asian pediatric cohorts remains scarce.
Wenjuan Liao, Xiaobin Tan, Jinhai Lin, Yuchen Wu, Qi Guo, Qucheng Huang, Longhe Yang, Yan Peng   +7 more
doaj   +1 more source

Circuit‐Selective FAAH Inhibition Suppresses Experimental Absence Seizures

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Selective inhibition of FAAH with PF‐04457845 enhances endogenous AEA signaling and suppresses absence seizures in Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Video‐EEG recordings demonstrate a marked reduction in SWDs following both acute and subchronic FAAH inhibitions.
Tatiana P. Morais, Cristiano Bombardi, Vincenzo Crunelli, Giuseppe Di Giovanni   +3 more
wiley   +1 more source

Arterial concentrations of palmitoylethanolamide.

, 2019
Panels A and B depict the same data of arterial concentrations of PEA [pmol/ml]. Data are presented as the mean ± standard error of the mean. For the purpose of clarity, values in panel (A) are grouped by extraction site, allowing for comparison of ...
Georg Nickenig (287655), Hanna Goerich (8201481), Vedat Tiyerili (4287751), Julian Jehle (586001), Laura Bindila (843199), Beat Lutz (24734)   +5 more
core   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain [PDF]

Journal of Neuroinflammation, 2014
The fatty acid amide palmitoylethanolamide (PEA) has been studied extensively for its anti-inflammatory and neuroprotective actions. The lipidic nature and large particle size of PEA in the native state may limit its solubility and bioavailability when given orally, however.
IMPELLIZZERI, DANIELA, BRUSCHETTA, GIUSEPPE, CORDARO, MARIKA, CRUPI, ROSALIA, SIRACUSA, ROSALBA, ESPOSITO, EMANUELA, CUZZOCREA, Salvatore   +6 more
openaire   +3 more sources

Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: a pilot study [PDF]

, 2020
Palmitoylethanolamide (PEA) is emerging as a new therapeutic approach in pain and inflammatory conditions, and it has been evaluated in studies on various painful diseases.
Tullo, Giulia, Federico Vigevano, Alaimo di Loro, Pierfrancesco, Laura Papetti, Michela Ada Noris Ferilli, Moavero, Romina, Ferilli, Michela Ada Noris, Giorgia Sforza, Tarantino, Samuela, Papetti, Laura, Valeriani, Massimiliano, Massimiliano Valeriani, Romina Moavero, Ursitti, Fabiana, Giulia Tullo, Sforza, Giorgia, Vigevano, Federico, Pierfrancesco Alaimo di Loro, Samuela Tarantino, Galli, Federica, Fabiana Ursitti   +20 more
core   +1 more source

The effects of formulated palmitoylethanolamide supplementation on indicators of stress and heart rate variability in female university students: a randomised cross-over trial

Frontiers in Nutrition
BackgroundChronic stress is a prevalent issue among university students, negatively affecting both mental and physiological health. Palmitoylethanolamide (PEA), particularly in the Levagen+® formulation, has been investigated for its potential stress ...
Sanjoy K. Deb, Sanjoy K. Deb, Nadia Kim, Brenda Parolin, Derek Renshaw, Mohammed Gulrez Zariwala   +5 more
doaj   +1 more source

N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation–Induced Dry Eye Syndrome

Frontiers in Pharmacology, 2020
Sleep loss is a key factor associated with dry eye. Use of a “stick over water” mouse model revealed that sleep deprivation induces accumulation of lipids, hypertrophy, and dysfunction of the lacrimal gland.
Qi Chen, Qi Chen, Qi Chen, Chunyan Ji, Chunyan Ji, Ruihe Zheng, Ruihe Zheng, Longhe Yang, Jie Ren, Jie Ren, Yitian Li, Yitian Li, Yun Han, Yun Han, Yun Han, Pan Zhou, Pan Zhou, Zuguo Liu, Zuguo Liu, Zuguo Liu, Yan Qiu, Yan Qiu, Yan Qiu   +22 more
doaj   +1 more source

The Effects of Palmitoylethanolamide or Ibuprofen on the Abundance Profile and Synthesis Rate of Proteins in C2C12 Skeletal Myotubes

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
(a) C2C12 myoblasts were cultured and differentiated over 7 days until mature myotubes were formed. (b) Myotubes were treated with PEA (10 μM), IBU (100 μM) or VC for 36 h. Simultaneously, cells were incubated with D2O (deuterium oxide) for isotopic labeling.
Paige L. Cole, Connor A. Stead, Jatin G. Burniston, Daniel J. Owens   +3 more
wiley   +1 more source

Partial Reversal of Striatal Damage by Palmitoylethanolamide Administration Following Perinatal Asphyxia

Frontiers in Neuroscience, 2020
Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas.
Lucas D. Udovin, Tamara Kobiec, Tamara Kobiec, María I. Herrera, María I. Herrera, Nicolás Toro-Urrego, Carlos F. Kusnier, Rodolfo A. Kölliker-Frers, Ana B. Ramos-Hryb, Juan P. Luaces, Matilde Otero-Losada, Francisco Capani, Francisco Capani   +12 more
doaj   +1 more source