Results 61 to 70 of about 3,153 (172)

Hypothesis: Clues From Mammalian Hibernation for Treating Patients With Anorexia Nervosa

open access: yesFrontiers in Psychology, 2018
This hypothesis is that anorexia nervosa (AN) is a biologically driven disorder, and mammalian hibernation may offer clues to its pathogenesis. Using this approach, this hypothesis offers suggestions for employing heart rate variability as an early ...
Barbara Scolnick
doaj   +1 more source

Metabolic Fingerprints of High‐Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation

open access: yesAnalysis &Sensing, Volume 6, Issue 4, July 2026.
This study presents a multimatrix untargeted metabolomics analysis of fecal, plasma, and urine samples from individuals at high risk for pancreatic cancer development. Integrated multivariate and cofactor‐adjusted models were applied to characterize cross‐matrix metabolomic associations, incorporating pancreatic magnetic resonance imaging data, sex ...
Vladyslav Dovhalyuk   +6 more
wiley   +1 more source

Distribution of Cannabinoid Receptors in Keratinocytes of Healthy Dogs and Dogs With Atopic Dermatitis

open access: yesFrontiers in Veterinary Science, 2022
It is commonly accepted that some form of skin barrier dysfunction is present in canine atopic dermatitis (AD), one of the most common cutaneous pruritic inflammatory diseases of dogs.
Roberto Chiocchetti   +7 more
doaj   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

open access: yesAutism Research, Volume 19, Issue 7, July 2026.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin   +3 more
wiley   +1 more source

Quantification of Analgesic and Anti-Inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic Membrane

open access: yesBioengineering, 2023
The aim of this study was to compare concentrations of endogenous N-acylethanolamine (NAE) lipid mediators—palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and anandamide (AEA)—in fresh, decontaminated, cryopreserved, and freeze-dried amniotic ...
Vladimir Vrkoslav   +7 more
doaj   +1 more source

Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer’s Disease [PDF]

open access: yesFrontiers in Pharmacology, 2019
N-Palmitoylethanolamide (PEA) is a non-endocannabinoid lipid mediator belonging to the class of the N-acylethanolamine phospolipids and was firstly isolated from soy lecithin, egg yolk, and peanut meal. Either preclinical or clinical studies indicate that PEA is potentially useful in a wide range of therapeutic areas, including eczema, pain, and ...
Sarah Beggiato   +7 more
openaire   +4 more sources

Unique/Rapid Feedback Mechanisms of PGD2 and PGE2 as Local/Short‐Lived Autacoids; Implications of Biased Activities by Their Metabolites

open access: yesBioEssays, Volume 48, Issue 7, July 2026.
Since autacoids are short‐lived bioactive substances that act near their site of biosynthesis, the biased activities of prostanoid metabolites may have significant physiological implications with regard to the newly defined and/or re‐acknowledged as unique and novel nongenomic feedback mechanisms, which may be one of very important roles of prostanoids
Hiromichi Fujino, Keijo Fukushima
wiley   +1 more source

Molecular Targets of Fatty Acid Ethanolamides in Asthma

open access: yesMedicina, 2019
Asthma is a common allergic pathology of the respiratory tract that requires the study of mechanisms underlying it, due to severe forms of the disease, which are refractory to therapy.
Oxana Kytikova   +4 more
doaj   +1 more source

Chronic orofacial pain management: A narrative review of pharmacological and promising therapy

open access: yesMedical Journal of Babylon, 2023
Chronic orofacial pain is a multifactorial stressful condition. It devastates patients’ lives and depletes medical and dental services. Assertion of a particular effective pharmacological treatment is difficult due to psychological involvement and ...
Malath Azeez Al-saadi
doaj   +1 more source

Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice [PDF]

open access: yesBritish Journal of Pharmacology, 2001
We have studied the effect of palmitoylethanolamide (PEA, 2.5 – 30 mg kg−1, i.p.) on upper gastrointestinal transit in control mice and in mice with chronic intestinal inflammation induced by croton oil. PEA significantly and dose‐dependently decreased intestinal transit.
CAPASSO, RAFFAELE   +6 more
openaire   +4 more sources

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