Results 61 to 70 of about 1,588 (158)

Metabolic Fingerprints of High‐Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation

Analysis &Sensing, Volume 6, Issue 4, July 2026.
This study presents a multimatrix untargeted metabolomics analysis of fecal, plasma, and urine samples from individuals at high risk for pancreatic cancer development. Integrated multivariate and cofactor‐adjusted models were applied to characterize cross‐matrix metabolomic associations, incorporating pancreatic magnetic resonance imaging data, sex ...
Vladyslav Dovhalyuk, Quang‐Dong Bui, Vincent Ripoll, Wiktor Rutkowski, Miroslav Vujasinovic, J.‐Matthias Löhr, Daniel Globisch   +6 more
wiley   +1 more source

Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-Inflammation

Pharmaceutics
Palmitoylethanolamide (PEA) exhibits multiple skincare functions such as anti-nociceptive and anti-inflammatory effects. However, its topical application is limited due to its difficulty in bypassing the stratum corneum barrier, relatively low ...
Chuanpeng Ren, Yanyun Ma, Yizhen Wang, Dan Luo, Yanhan Hong, Xinyuan Zhang, Hexiang Mei, Wei Liu   +7 more
doaj   +1 more source

Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats

Frontiers in Pharmacology, 2018
Background: Liver fibrosis is a complex inflammatory and fibrogenic process, and the progression of fibrosis leads to cirrhosis. The only therapeutic approaches are the removal of injurious stimuli and liver transplantation. Therefore, the development of
Masatsugu Ohara, Shunsuke Ohnishi, Hidetaka Hosono, Koji Yamamoto, Qingjie Fu, Osamu Maehara, Goki Suda, Naoya Sakamoto   +7 more
doaj   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Reply to: "Palmitoylethanolamide: problems regarding micronization, ultra-micronization and additives" Inflammopharmacology

, 2014
This is a reply to a recently published Commentary: "Palmitoylethanolamide: problems regarding micronization, ultra-micronization and additives" Inflammopharmacology DOI: 10.1007/s10787-014-0202-3 , written in relation to our review article: Skaper SD ...
Costa B, Skaper SD, Facci L, Fusco M, Zusso M, Giusti P., Della Valle MF   +6 more
core   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Innovative Nanoparticles Enhance N-Palmitoylethanolamide Intraocular Delivery [PDF]

Frontiers in Pharmacology, 2018
Nanostructured lipid carriers (NLCs) loaded with palmitoylethanolamide (PEA) were formulated with the aim to enhance ocular bioavailability of PEA, particularly to the back of the eye. Technological characterization (e.g., size, charge) of NLC loaded with PEA formulation (PEA-NLC) was performed, and NLC morphology was characterized by electron ...
Carmelo Puglia, Carmelo Puglia, Paolo Blasi, Carmine Ostacolo, Eduardo Sommella, Claudio Bucolo, Claudio Bucolo, Chiara B. M. Platania, Giovanni L. Romano, Federica Geraci, Filippo Drago, Filippo Drago, Debora Santonocito, Barbara Albertini, Pietro Campiglia, Giovanni Puglisi, Giovanni Puglisi, Rosario Pignatello, Rosario Pignatello   +18 more
openaire   +5 more sources

Polydatin Inhibits Neuroinflammation in Cerebral Ischemia–Reperfusion Injury Through Suppressing the CXCL3/CXCR2 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
PD can act on the CXCL3/CXCR2 axis, thereby inhibiting migration and activation of microglia and neutrophils, and thus alleviating the inflammatory response associated with CIRI, highlighting its potential as a therapeutic agent for CIRI. ABSTRACT Aim The aim of this study is to investigate the precise mechanisms by which Polydatin (PD) ameliorates ...
Youxiang Cui, Fangmei Hu, Shixin Wang, Zehua Liu, Jinzhou Chen, Mingyue Cui, Leilei Wang, Yuming Wang, Ning Wang, Yuhong Bian, Shuquan Lv, Huantian Cui   +11 more
wiley   +1 more source

Micronized palmitoylethanolamide/trans-polydatin treatment of endometriosis-related pain: a meta-analysis [PDF]

, 2017
Aim. To demonstrate clinical effectiveness of micronized palmitoylethanolamide-transpolydatin combination in reducing endometriotic chronic pelvic pain. Other endometriotic- pains were also assessed. Methods.
Indraccolo, Salvatore Renato, Indraccolo, Ugo, Mignini, Fiorenzo   +2 more
core   +3 more sources

Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells

Journal of Pain Research, 2013
Jan M Keppel Hesselink,1 David J Kopsky21Institute for Neuropathic Pain, Bosch en Duin, The Netherlands; 2Institute for Neuropathic Pain, Amsterdam, The NetherlandsAbstract: Chronic regional pain syndrome (CRPS) can be intractable to treat and patients ...
Keppel Hesselink JM, Kopsky DJ
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