Results 41 to 50 of about 3,153 (172)

Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy [PDF]

British Journal of Clinical Pharmacology, 2016
Palmitoylethanolamide (PEA) has been suggested to have useful analgesic properties and to be devoid of unwanted effects. Here, we have examined critically this contention, and discussed available data concerning the pharmacokinetics of PEA and its formulation.
Gabrielsson, Linda, Mattsson, Sofia, Fowler, Christopher J.   +2 more
openaire   +3 more sources

Palmitoylethanolamide Ameliorates Hippocampal Damage and Behavioral Dysfunction After Perinatal Asphyxia in the Immature Rat Brain

Frontiers in Neuroscience, 2018
Perinatal asphyxia (PA) is an obstetric complication associated with an impaired gas exchange. This health problem continues to be a determinant of neonatal mortality and neurodevelopmental disorders.
María I. Herrera, María I. Herrera, Lucas D. Udovin, Nicolás Toro-Urrego, Carlos F. Kusnier, Juan P. Luaces, Francisco Capani, Francisco Capani, Francisco Capani   +8 more
doaj   +1 more source

Antioxidant and Anti-Inflammatory Activity of Combined Phycocyanin and Palmitoylethanolamide in Human Lung and Prostate Epithelial Cells

Antioxidants, 2022
Inflammation involving the innate and adaptive immune systems is a normal response to infection; however, when allowed to continue unchecked, inflammation may result in several pathologies. Natural molecules with antioxidant properties can target the key
Loredana Bergandi, Giulia Apprato, Francesca Silvagno   +2 more
doaj   +1 more source

First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury

Biomolecules, 2022
Acute respiratory distress syndrome (ARDS) is a serious inflammatory lung disorder and a complication of SARS-CoV-2 infection. In patients with severe SARS-CoV-2 infection, the transition to ARDS is principally due to the occurrence of a cytokine storm ...
Aniello Schiano Moriello, Fiorentina Roviezzo, Fabio Arturo Iannotti, Giuseppina Rea, Marco Allarà, Rosa Camerlingo, Roberta Verde, Vincenzo Di Marzo, Stefania Petrosino   +8 more
doaj   +1 more source

Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes [PDF]

Journal of Biological Chemistry, 1997
Anandamide (arachidonoylethanolamide, AnNH) and palmitoylethanolamide (PEA) have been proposed as the physiological ligands, respectively, of central and peripheral cannabinoid receptors. Both of these receptors are expressed in immune cells, including macrophages and mast cells/basophils, where immunomodulatory and/or anti-inflammatory actions of AnNH
Bisogno T, Maurelli S, Melck D, De Petrocellis L, Di Marzo V   +4 more
openaire   +4 more sources

Co-Ultramicronized Palmitoylethanolamide/Luteolin Restores Oligodendrocyte Homeostasis via Peroxisome Proliferator-Activated Receptor-α in an In Vitro Model of Alzheimer’s Disease

Biomedicines, 2022
Oligodendrocytes are cells fundamental for brain functions as they form the myelin sheath and feed axons. They perform these critical functions thanks to the cooperation with other glial cells, mainly astrocytes.
Roberta Facchinetti, Marta Valenza, Chiara Gomiero, Giulia Federica Mancini, Luca Steardo, Patrizia Campolongo, Caterina Scuderi   +6 more
doaj   +1 more source

Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications

Biomolecules, 2022
Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic acid, is an endogenous lipid compound endowed with a plethora of pharmacological functions, including analgesic, neuroprotective, immune-modulating, and anti ...
Marta Valenza, Roberta Facchinetti, Luca Steardo, Caterina Scuderi   +3 more
doaj   +1 more source

Oral Adelmidrol Administration Up-Regulates Palmitoylethanolamide Production in Mice Colon and Duodenum through a PPAR-γ Independent Action

Metabolites, 2022
Adelmidrol is a promising palmitoylethanolamide (PEA) analog which displayed up-and-coming anti-inflammatory properties in several inflammatory conditions.
Alessandro Del Re, Irene Palenca, Luisa Seguella, Marcella Pesce, Chiara Corpetti, Luca Steardo, Sara Rurgo, Giovanni Sarnelli, Giuseppe Esposito   +8 more
doaj   +1 more source

Possible Anandamide and Palmitoylethanolamide involvement in human stroke [PDF]

Lipids in Health and Disease, 2010
Endocannabinoids (eCBs) are ubiquitous lipid mediators that act on specific (CB1, CB2) and non-specific (TRPV1, PPAR) receptors. Despite many experimental animal studies proved eCB involvement in the pathogenesis of stroke, such evidence is still lacking in human patients.
Naccarato M, Pizzuti D, Petrosino S, Simonetto M, Ferigo L, Grandi FC, Pizzolato G, Di Marzo V   +7 more
openaire   +6 more sources

Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy

Frontiers in Molecular Neuroscience, 2018
Research on the antiepileptic effects of (endo-)cannabinoids has remarkably progressed in the years following the discovery of fundamental role of the endocannabinoid (eCB) system in controlling neural excitability. Moreover, an increasing number of well-
Julia M. Post, Sebastian Loch, Raissa Lerner, Floortje Remmers, Ermelinda Lomazzo, Beat Lutz, Laura Bindila   +6 more
doaj   +1 more source