Results 41 to 50 of about 1,588 (158)

Palmitoylethanolamide Ameliorates Hippocampal Damage and Behavioral Dysfunction After Perinatal Asphyxia in the Immature Rat Brain

Frontiers in Neuroscience, 2018
Perinatal asphyxia (PA) is an obstetric complication associated with an impaired gas exchange. This health problem continues to be a determinant of neonatal mortality and neurodevelopmental disorders.
María I. Herrera, María I. Herrera, Lucas D. Udovin, Nicolás Toro-Urrego, Carlos F. Kusnier, Juan P. Luaces, Francisco Capani, Francisco Capani, Francisco Capani   +8 more
doaj   +1 more source

Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes [PDF]

Journal of Biological Chemistry, 1997
Anandamide (arachidonoylethanolamide, AnNH) and palmitoylethanolamide (PEA) have been proposed as the physiological ligands, respectively, of central and peripheral cannabinoid receptors. Both of these receptors are expressed in immune cells, including macrophages and mast cells/basophils, where immunomodulatory and/or anti-inflammatory actions of AnNH
Bisogno T, Maurelli S, Melck D, De Petrocellis L, Di Marzo V   +4 more
openaire   +4 more sources

Micronized Palmitoylethanolamide Ameliorates Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis via Inhibiting Inflammation and Restoring Autophagy

Frontiers in Pharmacology, 2021
Nonalcoholic steatohepatitis (NASH) has become one of the serious causes of chronic liver diseases, characterized by hepatic steatosis, hepatocellular injury, inflammation and fibrosis, and lack of efficient therapeutic agents. Palmitoylethanolamide (PEA)
Jiaji Hu, Hanglu Ying, Jie Yao, Longhe Yang, Wenhui Jin, Huabin Ma, Long Li, Yufen Zhao   +7 more
doaj   +1 more source

Possible Anandamide and Palmitoylethanolamide involvement in human stroke [PDF]

Lipids in Health and Disease, 2010
Endocannabinoids (eCBs) are ubiquitous lipid mediators that act on specific (CB1, CB2) and non-specific (TRPV1, PPAR) receptors. Despite many experimental animal studies proved eCB involvement in the pathogenesis of stroke, such evidence is still lacking in human patients.
Naccarato M, Pizzuti D, Petrosino S, Simonetto M, Ferigo L, Grandi FC, Pizzolato G, Di Marzo V   +7 more
openaire   +6 more sources

Base- and acid-catalyzed interconversions of O-acyl- and N-acyl-ethanolamines: a cautionary note for lipid analyses

Journal of Lipid Research, 2000
The isolation and quantification of ethanolamine containing lipids from animal tissues may expose neutral lipid extracts to acidic or basic conditions during chromatographic separations or derivatization chemistry.
S.P. Markey, T. Dudding, Tao-Chin L. Wang   +2 more
doaj   +1 more source

Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) hydrolase that catalyses the intracellular deactivation of the endogenous analgesic and anti-inflammatory agent palmitoylethanolamide (PEA). NAAA inhibitors counteract this process
Andrea Ghidini, Laura Scalvini, Francesca Palese, Alessio Lodola, Marco Mor, Daniele Piomelli   +5 more
doaj   +1 more source

To Go Where Nature Leads: Focus on Palmitoylethanolamide and Related ALIAmides As Innovative Approach to Neuroinflammatory and Pain-Related Disease States in Honor of Doctor Francesco Della Valle

, 2023
The primary compound at the core of ALIAmides, known as palmitoyl ethanolamide (PEA), has been recognized as a nutritional substance with protective qualities since the 1950s. Over time, PEA has been identified in a range of plant and animal food sources,

core   +1 more source

Effectiveness of an Oral Supplementation of Phycocyanin and Palmitoylethanolamide for a Short-Term Prophylaxis of Menstrual Migraine: A Retrospective Observational Study

Biomedicines
Background: Menstrual migraine (MM), including pure menstrual migraine (PMM) and menstrually related migraine (MRM), is characterized by attacks occurring in close temporal association with menstruation and is often more severe, longer lasting, and less ...
Gianni Allais, Massimo Autunno, Florindo D’Onofrio, Luisa Fofi, Maria Gabriella Saracco, Fabiola Bergandi, Chiara Benedetto, Francesca Silvagno, Loredana Bergandi   +8 more
doaj   +1 more source

Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2016
Chemotherapy-induced peripheral neuropathy (CIPN) represents a serious complication associated with antineoplastic drugs. Although there are no medications available that effectively prevent CIPN, many classes of drugs have been used to treat this condition, including anticonvulsants, serotonin and noradrenaline reuptake inhibitors, and opioids ...
Giulia, Donvito, Jenny L, Wilkerson, M Imad, Damaj, Aron H, Lichtman   +3 more
openaire   +2 more sources

Design, Characterization, and In Vitro Assays on Muscle Cells of Endocannabinoid-like Molecule Loaded Lipid Nanoparticles for a Therapeutic Anti-Inflammatory Approach to Sarcopenia

Pharmaceutics, 2022
Inflammatory processes play a key role in the pathogenesis of sarcopenia owing to their effects on the balance between muscle protein breakdown and synthesis. Palmitoylethanolamide (PEA), an endocannabinoid-like molecule, has been well documented for its
Eleonora Maretti, Susanna Molinari, Renata Battini, Cecilia Rustichelli, Eleonora Truzzi, Valentina Iannuccelli, Eliana Leo   +6 more
doaj   +1 more source