Results 121 to 130 of about 17,658,570 (203)

Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration

, 2001
Endogenous cannabinoid receptor ligands (endocannabinoids) may rescue neurons from glutamate excitotoxicity. As these substances also accumulate in cultured immature neurons following neuronal damage, elevated endocannabinoid concentrations may be ...
Patricia C. Schmid, Javier Fernández-Ruiz, J., Henrik H. Hansen, Manzanares, J., Schmid, P.C., Bittigau, P., Isabel Lastres‐Becker, Hansen, H.H., Petra Bittigau, Harald S. Hansen, Lastres-Becker, I., Fernando Berrendero, Schmid, H.H.O., Jorge Manzanares, Hansen, Harald S., Harald H. O. Schmid, Chrysanthy Ikonomidou, Ikonomidou, C., Berrendero, F., J. Javier Fernández‐Ruiz   +19 more
core   +1 more source

2-Arachidonoylglycerol Synthesis: Facile and Handy Enzymatic Method That Allows to Avoid Isomerization. [PDF]

Molecules, 2022
Ottria R, Casati S, Rota P, Ciuffreda P.
europepmc   +1 more source

RNA interference suggests a primary role for monoacylglycerol lipase in degradation of the endocannabinoid 2-arachidonoylglycerol.

, 2004
The endogenous cannabinoid, 2-arachidonoylglycerol (2-AG), is produced by neurons and other cells in a stimulus-dependent manner and undergoes rapid biological inactivation through transport into cells and catalytic hydrolysis.
Thien P Dinh, Satish Kathuria, Daniele Piomelli   +2 more
core  

Identifying Potential Human Monoacylglycerol Lipase Inhibitors from the Phytoconstituents of Morinda Citrifolia L. Fruits by in silico Pharmacology and in vitro Study

Journal of Experimental Pharmacology
Asman Sadino,1,2,* Nyi Mekar Saptarini,3 Jutti Levita,4,* Dwi Syah Fitra Ramadhan,5 Adryan Fristiohady,6 Supat Jiranusornkul7 1Doctoral Program in Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, 45363, Indonesia ...
Sadino A, Saptarini NM, Levita J, Ramadhan DSF, Fristiohady A, Jiranusornkul S   +5 more
doaj  

2-Arachidonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice. [PDF]

Alcohol Clin Exp Res, 2022
Morgan A, Adank D, Johnson K, Butler E, Patel S.   +4 more
europepmc   +1 more source

Differential inhibitory effects of endocannabinoids on neuronal firing of mouse meningeal afferents

The Journal of Headache and Pain
Background Increasing endocannabinoids (endoCBs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG), through inhibition of the degrading hydrolase enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively, has been ...
Georgii Krivoshein, Adriana Della Pietra, Juha Savinainen, Arn M. J. M. van den Maagdenberg, Rashid Giniatullin   +4 more
doaj   +1 more source

Augmentation of 2-arachidonoylglycerol signaling in astrocytes maintains synaptic functionality by regulation of miRNA-30b. [PDF]

Exp Neurol, 2023
Zhu D, Zhang J, Gao F, Hu M, Hashem J, Chen C.   +5 more
europepmc   +1 more source

A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways

, 2015
A basal tone of the endocannabinoid 2-arachidonoylglycerol (2-AG) enhances late oligodendrocyte progenitor cell (OPC) differentiation. Here, we investigated whether endogenous 2-AG may also promote OPC proliferation in earlier stages.
Ortega-Gutierrez, Silvia, Sanchez-Rodriguez, Maria A., Guaza, Carmen, Molina-Holgado, Francisco, Vazquez-Villa, Henar, Gomez, Oscar, Molina-Holgado, Eduardo   +6 more
core   +1 more source

Preparation of 2-Arachidonoylglycerol by Enzymatic Alcoholysis: Effects of Solvent and Water Activity on Acyl Migration. [PDF]

Foods, 2022
Wang X, Liu K, Wang Y, Huang Z, Wang X.
europepmc   +1 more source

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

, 2008
2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that, for anandamide, is mediated by fatty acid amide hydrolase (
Dana E. Selley, Li, Weiwei, Antonia M. Serrano, Joel E. Schlosburg, Loren H Parsons, Joel E Schlosburg, Dana E Selley, Long, Jonathan Z, Aron H. Lichtman, Jonathan Z. Long, James J Burston, Antonia M Serrano, Aron H Lichtman, Schlosburg, Joel E, James J. Burston, Cravatt, Benjamin F, Booker, Lamont, Selley, Dana E, Parsons, Loren H, Steven G Kinsey, Weiwei Li, Lamont Booker, Benjamin F Cravatt, Benjamin F. Cravatt, Franciso J. Pavón, Pavón, Franciso J, Lichtman, Aron H, Jonathan Z Long, Serrano, Antonia M, Kinsey, Steven G, Loren H, Franciso J Pavón, Burston, James J, Steven G. Kinsey   +33 more
core   +1 more source