Results 61 to 70 of about 12,036 (214)

Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol [PDF]

, 2002
Cb2 is a novel protooncogene encoding the peripheral cannabinoid receptor. Previous studies demonstrated that 2 distinct noncoding first exons exist: exon-1A and exon-1B, which both splice to protein-coding exon-2.
Alberich-Jorda, M. (Meritxell), Delwel, H.R. (Ruud), Finazzi-Agro, A., Löwenberg, B. (Bob), Maccarrone, M. (Mauro), Valk, P.J.M. (Peter), Vankan-Berkhoudt, Y.V. (Yolanda), Verbakel, S.E. (Sandra)   +7 more
core   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels [PDF]

Bioorganic & Medicinal Chemistry Letters, 2008
The structure-activity relationships of organophosphorus (OP) and organosulfur compounds were examined in vitro and in vivo as inhibitors of mouse brain monoacylglycerol lipase (MAGL) hydrolysis of 2-arachidonoylglycerol (2-AG) and agonist binding at the CB1 receptor.
Nomura, Daniel K, Hudak, Carolyn S S, Ward, Anna M, Burston, James J, Issa, Roger S, Fisher, Karl J, Abood, Mary E, Wiley, Jenny L, Lichtman, Aron H, Casida, John E   +9 more
openaire   +2 more sources

Endocannabinoids and the Processing of Value-Related Signals [PDF]

, 2012
Endocannabinoids serve as retrograde signaling molecules at many synapses within the CNS, particularly GABAergic and glutamatergic synapses. Synapses onto midbrain dopamine (DA) neurons in the ventral tegmental area (VTA) make no exception to this rule ...
Miriam eMelis, Miriam eMelis, Anna Lisa eMuntoni, Anna Lisa eMuntoni, Marco ePistis, Marco ePistis, Marco ePistis   +6 more
core   +2 more sources

Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study

Addiction, Volume 121, Issue 5, Page 1179-1189, May 2026.
Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
María Salud García‐Gutiérrez, Abraham Bailén Torregrosa, Francisco Navarrete, Auxiliadora Aracil‐Fernández, Gabriel Rubio, Jorge Manzanares   +5 more
wiley   +1 more source

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects

Nutrition & Metabolism, 2011
We have previously shown that krill oil (KO), more efficiently than fish oil, was able to downregulate the endocannabinoid system in different tissues of obese zucker rats.
Giordano Elena, Cordeddu Lina, Murru Elisabetta, Carta Gianfranca, Banni Sebastiano, Sirigu Anna, Berge Kjetil, Vik Hogne, Maki Kevin C, Di Marzo Vincenzo, Griinari Mikko   +10 more
doaj   +1 more source

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Cell Reports, 2020
Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj   +1 more source

Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging

Experimental Gerontology, 2014
2-Arachidonoylglycerol (2-AG) is one of the principal endocannabinoids involved in the protection against neurodegenerative processes. Cannabinoids primarily interact with the seven-segment transmembrane cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), both of which are expressed in the central nervous system (CNS).
Ana C, Pascual, Virginia L, Gaveglio, Norma M, Giusto, Susana J, Pasquaré   +3 more
openaire   +2 more sources

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects [PDF]

Nature Chemical Biology, 2008
2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (FAAH), and for 2-AG is thought to involve monoacylglycerol lipase (MAGL). FAAH inhibitors produce
Long, Jonathan Z., Li, Weiwei, Booker, Lamont, Burston, James J., Kinsey, Steven G., Schlosburg, Joel E., Pavón, Franciso J., Serrano, Antonia M., Selley, Dana E., Parsons, Loren H., Lichtman, Aron H., Cravatt, Benjamin F.   +11 more
openaire   +2 more sources

Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study. [PDF]

, 2016
Gonadotropin-releasing hormone (GnRH) neurons are controlled by 17beta-estradiol (E2) contributing to the steroid feedback regulation of the reproductive axis.
Bálint, Flóra, Farkas, Imre, Liposits, Zsolt   +2 more
core   +1 more source