Results 61 to 70 of about 17,658,570 (203)

A Methodology for Radiolabeling of the Endocannabinoid 2-Arachidonoylglycerol (2-AG)

, 2016
The metabolic intermediate and endocannabinoid signaling lipid 2-arachidonoylglycerol (2-AG) has not been readily labeled, primarily because of its instability toward rearrangement.
Alexandros Makriyannis (32548), Sherrye T. Glaser (479290), Subramanian K. Vadivel (309316), Meghan Johnston (2216059), S. John Gatley (1749211), Richard I. Duclos (1749199)   +5 more
core   +1 more source

A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α

Journal of Lipid Research, 2015
The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase α (DAGL-α) in the CNS. Selective inhibitors of DAGL-α will provide valuable insights in the role of 2-AG in endocannabinoid signaling ...
Tom van der Wel, Freek J. Janssen, Marc P. Baggelaar, Hui Deng, Hans den Dulk, Herman S. Overkleeft, Mario van der Stelt   +6 more
doaj   +1 more source

Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells

Brain Pathology, Volume 36, Issue 4, July 2026.
Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son, Suji Kim, Min‐Tae Jeon, Moonseok Choi, Kyu‐Sung Kim, Suji Lee, Seung‐Yeol Nah, Do‐Geun Kim   +7 more
wiley   +1 more source

Placental DAGLbeta Regulates 2-arachidonoylglycerol Levels and Is Involved in Pregnancy Induced Inflammation

, 2021
Diacylglycerollipase alpha/beta (DAGLa/b) are two sequencerelated serine hydrolases, biosynthesizing 2-arachidonoylglycerol (2-AG). 2-AG, one of the main endocannabinoids, and its esterified fatty acid arachidonic acid serve as substrates for pro ...
Zimmermann, R., Hirschmugl, Birgit, Wadsack, Christian, Berger, Natascha, Gindlhuber, Juergen, Birner-Grünberger, Ruth   +5 more
core   +1 more source

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects

Nutrition & Metabolism, 2011
We have previously shown that krill oil (KO), more efficiently than fish oil, was able to downregulate the endocannabinoid system in different tissues of obese zucker rats.
Giordano Elena, Cordeddu Lina, Murru Elisabetta, Carta Gianfranca, Banni Sebastiano, Sirigu Anna, Berge Kjetil, Vik Hogne, Maki Kevin C, Di Marzo Vincenzo, Griinari Mikko   +10 more
doaj   +1 more source

Cannabigerol Alleviates Obesity‐Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Graphical overview of the effects of the high‐fat, high‐sucrose (HFHS) diet regime and 2‐week cannabigerol (CBG) treatment on the intramuscular long‐chain fatty acids (LCFAs) trafficking and lipid metabolism, with subsequent implications for mitochondrial cardiolipin (CL) composition in the red gastrocnemius muscle.
Patrycja Bielawiec, Karolina Konstantynowicz‐Nowicka, Adrian Chabowski, Ewa Harasim‐Symbor   +3 more
wiley   +1 more source

Effect of environmental temperature on oxidative status, inflammatory response and endocannabinoid system at oestrus in dairy cows

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Heat stress (HS) poses a significant challenge to dairy production under climate change, as it compromises fertility, productivity and overall health in cows. This seasonal observational cross‐sectional study investigated how environmental temperature affects oxidative status, inflammatory responses and endocannabinoid system (ECS ...
Alice Carbonari, Lorenza Frattina, Matteo Burgio, Vincenzo Cicirelli, Michal Andrzej Kosior, Alessandra Sfacteria, Bianca Gasparrini, Gabriele Marino, Roberta Verde, Fabiana Piscitelli, Annalisa Rizzo   +10 more
wiley   +1 more source

Distinct serum endocannabinoid profiles in treatment-naïve Han Chinese children with ADHD: a case–control pilot study

Frontiers in Neurology
ObjectiveAlthough peripheral endocannabinoid system (ECS) signatures have been implicated in ADHD among European and American populations, evidence from Asian pediatric cohorts remains scarce.
Wenjuan Liao, Xiaobin Tan, Jinhai Lin, Yuchen Wu, Qi Guo, Qucheng Huang, Longhe Yang, Yan Peng   +7 more
doaj   +1 more source

Oxyradical Stress, Endocannabinoids, and Atherosclerosis

Toxics, 2015
Atherosclerosis is responsible for most cardiovascular disease (CVD) and is caused by several factors including hypertension, hypercholesterolemia, and chronic inflammation.
Anberitha T. Matthews, Matthew K. Ross
doaj   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source