Results 21 to 30 of about 24,579,074 (168)

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

Nature Communications, 2022
2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism ...
Zhenhua Liu, Nannan Yang, Jie Dong, Wotu Tian, Lisa Chang, Jinghong Ma, Jifeng Guo, Jieqiong Tan, Ao Dong, Kaikai He, Jingheng Zhou, Resat Cinar, Junbing Wu, Armando G. Salinas, Lixin Sun, Mantosh Kumar, Breanna T. Sullivan, Braden B. Oldham, Vanessa Pitz, Mary B. Makarious, Jinhui Ding, Justin Kung, Chengsong Xie, Sarah L. Hawes, Lupeng Wang, Tao Wang, Piu Chan, Zhuohua Zhang, Weidong Le, Shengdi Chen, David M. Lovinger, Cornelis Blauwendraat, Andrew B. Singleton, Guohong Cui, Yulong Li, Huaibin Cai, Beisha Tang   +36 more
doaj   +1 more source

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Geisslinger, Gerd, Gerd Geisslinger, Nowicki, Marcin, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Marcin Nowicki (109802), Ingo Bechmann (109810), Faramarz Dehghani (109822), Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Bechmann, Ingo, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Constance Hobusch, Ingo Bechmann, Kallendrusch, Sonja, Bechmann, Ingo Jürgen, Marcin Nowicki, Marco Koch, Angela Ehrlich (109799)   +27 more
core   +2 more sources

Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain

Molecules, 2021
The cannabinoid system is independently affected by stress and chronic ethanol exposure. However, the extent to which co-occurrence of traumatic stress and chronic ethanol exposure modulates the cannabinoid system remains unclear.
Veronica M. Piggott, Scott C. Lloyd, James I. Matchynski, Shane A. Perrine, Alana C. Conti   +4 more
doaj   +1 more source

Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand [PDF]

, 1997
Two endogenous ligands for cannabinoid receptors, anandamide (arachidonylethanolamide) and 2-arachidonoylglycerol, lose their biological activities by enzymatic hydrolysis.
Hiroko Yamaguchi, Goparaju, Sravan Kumar, Yamamoto, Shozo, Shozo Yamamoto, Sravan Kumar Goparaju, Natsuo Ueda, Ueda, Natsuo, Yamaguchi, Hiroko   +7 more
core   +1 more source

Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. [PDF]

PLoS ONE, 2012
In this study, we examined alterations in the hypothalamic reward system related to high-fat diet (HFD) preferences. We previously reported that hypothalamic 2-arachidonoylglycerol (2-AG) and glial fibrillary acid protein (GFAP) were increased after ...
Sei Higuchi, Keiichi Irie, Ryuji Yamaguchi, Mai Katsuki, Maiko Araki, Makiko Ohji, Kazuhide Hayakawa, Shohei Mishima, Yoshiharu Akitake, Kiyoshi Matsuyama, Kenji Mishima, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara   +13 more
doaj   +1 more source

Circulating Endocannabinoids as Diagnostic Markers of Canine Chronic Enteropathies: A Pilot Study

Frontiers in Veterinary Science, 2021
Chronic enteropathies (CEs) in dogs, according to the treatment response to consecutive trials, are classified as food-responsive (FRE), antibiotic-responsive (ARE), and immunosuppressive-responsive (IRE) enteropathy.
Elettra Febo, Paolo Emidio Crisi, Sergio Oddi, Sergio Oddi, Marco Pietra, Giorgia Galiazzo, Fabiana Piscitelli, Alessandro Gramenzi, Roberta Di Prinzio, Morena Di Tommaso, Nicola Bernabò, Nicola Bernabò, Tiziana Bisogno, Mauro Maccarrone, Mauro Maccarrone, Andrea Boari   +15 more
doaj   +1 more source

Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs[S]

Journal of Lipid Research, 2014
The analysis of peripheral endocannabinoids (ECs) is a good biomarker of the EC system. Their concentrations, from clinical studies, strongly depend on sample collection and time processing conditions taking place in clinical and laboratory settings. The
Antoni Pastor, Magí Farré, Montserrat Fitó, Fernando Fernandez-Aranda, Rafael de la Torre   +4 more
doaj   +1 more source

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer ...
Klaudia Barabas, Yanagawa, Yuchio, Harkany, Tibor, Giuseppe Tortoriello, Masaaki Torii, Cameron, Gary, Yuchio Yanagawa, Tortoriello, Giuseppe, Gary Cameron, Morozov, Yury M, Watanabe, Masahiko, Masahiko Watanabe, Barabas, Klaudia, Erik Keimpema, Ken Mackie, Keimpema, Erik, Tibor Harkany, Yury M. Morozov, Torii, Masaaki, Mackie, Ken, Watanabe, M, Harkany, T,, Cameron, G, Torii, M, Mackie, K, Tortoriello, G,, Keimpema, E,, Barabas, K, Yanagawa, Y, Morozov, YM   +29 more
core   +1 more source

Chemical tools to modulate 2-arachidonoylglycerol biosynthesis [PDF]

, 2017
2‐Arachidonoylglycerol (2‐AG) is an important endogenous signaling lipid that activates the cannabinoid receptors (CB1R and CB2R), thereby regulating a diverse range of physiological processes including anxiety, appetite, inflammation, memory, pain ...
Stelt, M. van der, Hui Deng, Mario van der Stelt, Deng, H.   +3 more
core   +1 more source

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]

, 2012
Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Andres Beiras Fernandez, Roland Toth, Markus Giehl, Weis, Florian, Erich Kilger, Beiras-Fernandez, Andres, Campolongo, Patrizia, Giehl, Markus, Schelling, Gustav, Florian Weis, Strewe, Claudia, Toth, Roland, Mirjam Schopp, Gustav Schelling, Daniela Hauer, Kilger, Erich, Schopp, Mirjam, Hauer, Daniela, Claudia Strewe   +18 more
core   +1 more source