Results 21 to 30 of about 17,658,570 (203)

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Progress in Lipid Research, 2018
2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation ...
Baggelaar, M.P., Maccarrone, M., Stelt, M. van der   +2 more
openaire   +6 more sources

Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway

Journal of Cellular Biochemistry, 2011
The endogenous cannabinoid 2-arachidonoylglycerol (2-AG) is described as a platelet agonist able to induce aggregation and to increase intracellular calcium. In the present report we have confirmed these data and demonstrated that the inhibitor of p38MAPK SB203580 and the inhibitor of cPLA(2) metabolism ETYA affect both these parameters. Thus, we aimed
SIGNORELLO, MARIA GRAZIA, Giacobbe, E, LEONCINI, GIULIANA   +2 more
openaire   +3 more sources

Inhibiting degradation of 2-arachidonoylglycerol as a therapeutic strategy for neurodegenerative diseases. [PDF]

Pharmacol Ther, 2023
Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most abundant endocannabinoid and is a full agonist of G-protein-coupled cannabinoid receptors (CB1R and CB2R), which are targets of Δ9-tetrahydrocannabinol (Δ9-THC), the main ...
Chen C.
europepmc   +3 more sources

ABHD6 and MAGL control 2-AG levels in the PAG and allodynia in a CSD-induced periorbital model of headache

Frontiers in Pain Research, 2023
IntroductionThe high prevalence and severe symptoms of migraines in humans emphasizes the need to identify underlying mechanisms that can be targeted for therapeutic benefit.
Erika Liktor-Busa, Aidan A. Levine, Seph M. Palomino, Simar Singh, Jared Wahl, Todd W. Vanderah, Nephi Stella, Nephi Stella, Tally M. Largent-Milnes   +8 more
doaj   +1 more source

Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. [PDF]

PLoS ONE, 2013
Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms.
Peter M Zygmunt, Anna Ermund, Pouya Movahed, David A Andersson, Charlotte Simonsen, Bo A G Jönsson, Anders Blomgren, Bryndis Birnir, Stuart Bevan, Alain Eschalier, Christophe Mallet, Ana Gomis, Edward D Högestätt   +12 more
doaj   +1 more source

2-Arachidonoylglycerol [PDF]

Cancer Research, 2004
Abstract Endocannabinoids have been implicated in cancer. Increasing endogenous 2-arachidonoylglycerol (2-AG) by blocking its metabolism inhibits invasion of androgen-independent prostate cancer (PC-3 and DU-145) cells. Noladin ether (a stable 2-AG analog) and exogenous CB1 receptor agonists possess similar effects.
Kasem Nithipatikom, Michael P. Endsley, Marilyn A. Isbell, John R. Falck, Yoshiki Iwamoto, Cecilia J. Hillard, William B. Campbell   +6 more
openaire   +1 more source

Peripheral endocannabinoids in eating disorders and obesity and its relationship with clinical and anthropometric variables

European Psychiatry, 2021
Introduction Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) play a pivotal role in food intake and reward aspects of feeding. Aberrant functioning in the endocannabinoid system has been observed in patients with eating disorders (EDs).
I. Baenas-Soto, R. Miranda-Olivos, L. Vos, R. Granero, I. Sánchez, N. Riesco, A. Del Pino-Gutiérrez, E. Codina, J. A. Fernández-Formoso, N. Vilarrasa, N. Virgili, R. Lopez-Urdiales, A. Pastor, R. De La Torrre, S. Jimenez-Murcia, C. Soriano-Mas, F. Fernandez-Aranda   +16 more
doaj   +1 more source

Conformationally constrained analogues of 2-arachidonoylglycerol [PDF]

Bioorganic & Medicinal Chemistry Letters, 2007
Novel monocyclic analogues of 2-arachidonoylglycerol (2-AG) were designed in order to explore the pharmacophoric conformations of this endocannabinoid ligand at the key cannabinergic proteins. All 2-arachidonoyl esters of 1,2,3-cyclohexanetriol [meso-7 (AM5504), (+/-)-8 (AM5503), and meso-9 (AM5505)] were synthesized by regioselective acylation of 2,3 ...
Subramanian K, Vadivel, Sundararaman, Vardarajan, Richard I, Duclos, JodiAnne T, Wood, Jianxin, Guo, Alexandros, Makriyannis   +5 more
openaire   +2 more sources

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

The Journal of Headache and Pain, 2023
Background Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide (AEA), was proposed as a ...
Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M. J. M. van den Maagdenberg, Juha Savinainen, Rashid Giniatullin   +9 more
doaj   +1 more source

Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures

Frontiers in Neural Circuits, 2022
Research on endocannabinoid signaling has greatly advanced our understanding of how the excitability of neural circuits is controlled in health and disease.
Yuki Sugaya, Yuki Sugaya, Masanobu Kano, Masanobu Kano   +3 more
doaj   +1 more source