Results 21 to 30 of about 12,036 (214)

Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain

Molecules, 2021
The cannabinoid system is independently affected by stress and chronic ethanol exposure. However, the extent to which co-occurrence of traumatic stress and chronic ethanol exposure modulates the cannabinoid system remains unclear.
Veronica M. Piggott, Scott C. Lloyd, James I. Matchynski, Shane A. Perrine, Alana C. Conti   +4 more
doaj   +1 more source

2-Arachidonoylglycerol (2-AG) membrane transport: History and outlook [PDF]

The AAPS Journal, 2006
Only a few studies have addressed the transport of 2-arachidonoylglycerol (2-AG), a naturally occurring agonist for cannabinoid receptors. Based upon saturation kinetics, these early reports have proposed that 2-AG enters the cell by a specific 2-AG transporter, via the putative anandamide transporter, or by simple diffusion. In this review, the uptake
Anita, Hermann, Martin, Kaczocha, Dale G, Deutsch   +2 more
openaire   +2 more sources

Circulating endocannabinoid levels in pregnant women with gestational diabetes mellitus: a case–control study

BMC Endocrine Disorders, 2022
Background The role of the Endocannabinoids (ECs) in insulin resistance, and their association with visceral obesity and metabolic profile have been studied extensively.
Hadi Bazyar, Khadijeh Nasiri, Parisa Ghanbari, Elahe Mohammadi, Neda Lotfi Yagin, Maryam Khazdouz, Vahideh Aghamohammadi, Shafagh Ali Asgarzadeh   +7 more
doaj   +1 more source

Circulating Endocannabinoids as Diagnostic Markers of Canine Chronic Enteropathies: A Pilot Study

Frontiers in Veterinary Science, 2021
Chronic enteropathies (CEs) in dogs, according to the treatment response to consecutive trials, are classified as food-responsive (FRE), antibiotic-responsive (ARE), and immunosuppressive-responsive (IRE) enteropathy.
Elettra Febo, Paolo Emidio Crisi, Sergio Oddi, Sergio Oddi, Marco Pietra, Giorgia Galiazzo, Fabiana Piscitelli, Alessandro Gramenzi, Roberta Di Prinzio, Morena Di Tommaso, Nicola Bernabò, Nicola Bernabò, Tiziana Bisogno, Mauro Maccarrone, Mauro Maccarrone, Andrea Boari   +15 more
doaj   +1 more source

2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts [PDF]

Cell Cycle, 2014
Platelets modulate vascular system integrity, and their loss is critical in haematological pathologies and after chemotherapy. Therefore, identification of molecules enhancing platelet production would be useful to counteract thrombocytopenia. We have previously shown that 2-arachidonoylglycerol (2-AG) acts as a true agonist of platelets, as well as it
GASPERI, VALERIA, AVIGLIANO, LUCIANA, Evangelista, D, Oddi, S, Chiurchiù, V, Lanuti, M, Maccarrone, M, CATANI, MARIA VALERIA   +7 more
openaire   +3 more sources

The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation [PDF]

, 2011
Several mechanisms have been proposed for the positive health effects associated with dietary consumption of long-chain n-3 PUFA (n-3 LC-PUFA) including DHA (22 : 6n-3) and EPA (20 : 5n-3).
Attya, M., Balvers, M.G.J., Gabriele, B., Gruppen, H., Meijerink, J., Plastina, P., Poland, M.C.R., Vincken, J.P., Witkamp, R.F.   +8 more
core   +7 more sources

2-arachidonoylglycerol signaling impairs short-term fear extinction [PDF]

Translational Psychiatry, 2016
AbstractImpairments in fear extinction are thought to be central to the psychopathology of posttraumatic stress disorder, and endocannabinoid (eCB) signaling has been strongly implicated in extinction learning. Here we utilized the monoacylglycerol lipase inhibitor JZL184 to selectively augment brain 2-AG levels combined with an auditory cue fear ...
Hartley, ND, Gunduz-Cinar, O, Halladay, L, Bukalo, O, Holmes, A, Patel, S   +5 more
openaire   +3 more sources

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]

, 2012
Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Beiras-Fernandez, Andres, Campolongo, Patrizia, Giehl, Markus, Hauer, Daniela, Kilger, Erich, Schelling, Gustav, Schopp, Mirjam, Strewe, Claudia, Toth, Roland, Weis, Florian   +9 more
core   +1 more source

Endocannabinoid system and anticancer properties of cannabinoids [PDF]

, 2016
Cannabinoids impact human body by binding to cannabinoids receptors (CB1 and CB2). The two main phytocannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).
Nowak, Agnieszka, Słomski, Ryszard, Zeyland, Joanna, Śledziński, Paweł   +3 more
core   +2 more sources

New Perspectives in the Studies on Endocannabinoid and Cannabis: 2-Arachidonoylglycerol as a Possible Novel Mediator of Inflammation

Journal of Pharmacological Sciences, 2004
2-Arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors. To date, two types of cannabinoid receptors (CB1 and CB2) have been identified. The CB1 receptor is assumed to be involved in the attenuation of synaptic transmission.
Takayuki Sugiura, Saori Oka, Maiko Gokoh, Seishi Kishimoto, Keizo Waku   +4 more
doaj   +1 more source