Results 11 to 20 of about 17,658,570 (203)

Photorelease of 2-Arachidonoylglycerol in Live Cells. [PDF]

J Am Chem Soc, 2019
2-Arachidonoylglycerol (2-AG) is acting as a full agonist of cannabinoid receptor 1 and 2. Direct manipulation of 2-AG levels is a challenging task. The amphiphilic properties and the instability of 2-AG in aqueous media complicate its use as a drug-like molecule.
Laguerre A, Hauke S, Qiu J, Kelly MJ, Schultz C.   +4 more
europepmc   +5 more sources

The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. [PDF]

PLoS ONE, 2015
The endocannabinoid system is expressed in bone, although its role in the regulation of bone growth is controversial. Many studies have examined the effect of endocannabinoids directly on osteoclast function, but few have examined their role in human ...
Marie Smith, Richard Wilson, Sally O'Brien, Cristina Tufarelli, Susan I Anderson, Saoirse Elizabeth O'Sullivan   +5 more
doaj   +2 more sources

Chemical tools to modulate 2‐arachidonoylglycerol biosynthesis

Biotechnology and Applied Biochemistry, 2017
Abstract2‐Arachidonoylglycerol (2‐AG) is an important endogenous signaling lipid that activates the cannabinoid receptors (CB1R and CB2R), thereby regulating a diverse range of physiological processes including anxiety, appetite, inflammation, memory, pain sensation, and nociception.
Deng, H., Stelt, M. van der
openaire   +6 more sources

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats

Frontiers in Pharmacology, 2022
Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinction,
William G. Warren, Eleni P. Papagianni, Ed Hale, Rebecca A. Brociek, Helen J. Cassaday, Carl W. Stevenson   +5 more
doaj   +3 more sources

Tetrahydrolipstatin Analogues as Modulators of Endocannabinoid 2-Arachidonoylglycerol Metabolism [PDF]

Journal of Medicinal Chemistry, 2008
A series of 21 analogues of tetrahydrolipstatin (THL, 1) were synthesized and tested as inhibitors of the formation or hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). Three of the novel compounds, i.e., 11, 13, and 15, inhibited 2-AG formation via the diacylglycerol lipase alpha (DAGLalpha) with IC 50 values lower than 50 nM (IC 50 of ...
Giorgio Ortar, Tiziana Bisogno, Alessia Ligresti, Enrico Morera, Marianna Nalli, Vincenzo Di Marzo   +5 more
openaire   +4 more sources

Production of the endocannabinoids anandamide and 2‐arachidonoylglycerol by endothelial progenitor cells [PDF]

FEBS Letters, 2007
Recent studies have highlighted the importance of paracrine growth factors as mediators of pro‐angiogenic effects by endothelial progenitor cells (EPCs), but little is known about the release of lipid‐based factors like endocannabinoids by EPCs. In the current study, the release of the endocannabinoids anandamide and 2‐arachidonoylglycerol by distinct ...
Opitz, Christiane A., Rimmerman, Neta, Zhang, Yanmin, Mead, Laura E., Yoder, Mervin C., Ingram, David A., Walker, J. Michael, Rehman, Jalees   +7 more
openaire   +3 more sources

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +4 more sources

Determination of 2-Arachidonoylglycerol by μSPE-LC-MS/MS

, 2016
LC-MS/MS is a powerful analytical technique that provides unequivocal identification and reliable quantification of the analytes, using Selected Reaction Monitoring or Multi Reaction Monitoring acquisition mode.2-Arachidonoylglycerol (2-AG) is the most abundant endocannabinoid, which plays a major role in a wide variety of physiological and ...
BATTISTA, Natalia, SERGI, Manuel
openaire   +5 more sources

Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy

Drug Discovery Today, 2014
The endocannabinoid system is implicated in, and regulates, several physiological processes, ranging from food intake and energy balance to pain and inflammation. 2-Arachidonoylglycerol (2-AG) is a full agonist at the cannabinoid receptors which classically mediate its effects. The activity of this bioactive lipid is dependent on its endogenous levels,
Mireille, Alhouayek, Julien, Masquelier, Giulio G, Muccioli   +2 more
openaire   +3 more sources

Serum contents of endocannabinoids are correlated with blood pressure in depressed women

Lipids in Health and Disease, 2012
Background Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in ...
Ho WS Vanessa, Hill Matthew N, Miller Gregory E, Gorzalka Boris B, Hillard Cecilia J   +4 more
doaj   +2 more sources