Results 11 to 20 of about 12,036 (214)
The neuroprotective mechanism of 2-arachidonoylglycerol 2-AG against non-caspase-dependent apoptosis in mice hippocampal neurons following MCAO [PDF]
Neuropsychiatric Disease and Treatment, 2019 He-Ying Zhong, Zhou Yang, Zhen Qiu, Shao-Qing Lei, Zhong-Yuan XiaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of ChinaCorrespondence: Zhong-Yuan XiaDepartment of Anesthesiology, Renmin ...
Zhong HY, Yang Z, Qiu Z, Lei SQ, Xia ZY
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Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]
, 2012 BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen +8 more
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Frontiers in Pain Research, 2023 IntroductionThe high prevalence and severe symptoms of migraines in humans emphasizes the need to identify underlying mechanisms that can be targeted for therapeutic benefit.
Erika Liktor-Busa +8 more
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Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. [PDF]
PLoS ONE, 2013 Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms.
Peter M Zygmunt +12 more
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Cancer Research, 2004 Abstract Endocannabinoids have been implicated in cancer. Increasing endogenous 2-arachidonoylglycerol (2-AG) by blocking its metabolism inhibits invasion of androgen-independent prostate cancer (PC-3 and DU-145) cells. Noladin ether (a stable 2-AG analog) and exogenous CB1 receptor agonists possess similar effects.
Kasem Nithipatikom +6 more
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The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. [PDF]
PLoS ONE, 2015 The endocannabinoid system is expressed in bone, although its role in the regulation of bone growth is controversial. Many studies have examined the effect of endocannabinoids directly on osteoclast function, but few have examined their role in human ...
Marie Smith +5 more
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European Psychiatry, 2021 Introduction Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) play a pivotal role in food intake and reward aspects of feeding. Aberrant functioning in the endocannabinoid system has been observed in patients with eating disorders (EDs).
I. Baenas-Soto +16 more
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Conformationally constrained analogues of 2-arachidonoylglycerol [PDF]
Bioorganic & Medicinal Chemistry Letters, 2007 Novel monocyclic analogues of 2-arachidonoylglycerol (2-AG) were designed in order to explore the pharmacophoric conformations of this endocannabinoid ligand at the key cannabinergic proteins. All 2-arachidonoyl esters of 1,2,3-cyclohexanetriol [meso-7 (AM5504), (+/-)-8 (AM5503), and meso-9 (AM5505)] were synthesized by regioselective acylation of 2,3 ...
Subramanian K, Vadivel +5 more
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The Journal of Headache and Pain, 2023 Background Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide (AEA), was proposed as a ...
Adriana Della Pietra +9 more
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Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures
Frontiers in Neural Circuits, 2022 Research on endocannabinoid signaling has greatly advanced our understanding of how the excitability of neural circuits is controlled in health and disease.
Yuki Sugaya +3 more
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