Results 11 to 20 of about 24,579,074 (168)
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. [PDF]
PLoS ONE, 2015 The endocannabinoid system is expressed in bone, although its role in the regulation of bone growth is controversial. Many studies have examined the effect of endocannabinoids directly on osteoclast function, but few have examined their role in human ...
Marie Smith +5 more
doaj +2 more sources
Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats [PDF]
Frontiers in Pharmacology, 2022 Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinction,
William G. Warren +5 more
doaj +2 more sources
Serum contents of endocannabinoids are correlated with blood pressure in depressed women [PDF]
Lipids in Health and Disease, 2012 Background Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in ...
Ho WS Vanessa +4 more
doaj +2 more sources
Photorelease of 2-Arachidonoylglycerol in Live Cells. [PDF]
J Am Chem Soc, 2019 2-Arachidonoylglycerol (2-AG) is acting as a full agonist of cannabinoid receptor 1 and 2. Direct manipulation of 2-AG levels is a challenging task. The amphiphilic properties and the instability of 2-AG in aqueous media complicate its use as a drug-like
Laguerre A +4 more
europepmc +2 more sources
Frontiers in Pain Research, 2023 IntroductionThe high prevalence and severe symptoms of migraines in humans emphasizes the need to identify underlying mechanisms that can be targeted for therapeutic benefit.
Erika Liktor-Busa +8 more
doaj +1 more source
Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. [PDF]
PLoS ONE, 2013 Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms.
Peter M Zygmunt +12 more
doaj +1 more source
European Psychiatry, 2021 Introduction Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) play a pivotal role in food intake and reward aspects of feeding. Aberrant functioning in the endocannabinoid system has been observed in patients with eating disorders (EDs).
I. Baenas-Soto +16 more
doaj +1 more source
Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures
Frontiers in Neural Circuits, 2022 Research on endocannabinoid signaling has greatly advanced our understanding of how the excitability of neural circuits is controlled in health and disease.
Yuki Sugaya +3 more
doaj +1 more source
The Journal of Headache and Pain, 2023 Background Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide (AEA), was proposed as a ...
Adriana Della Pietra +9 more
doaj +1 more source
BMC Endocrine Disorders, 2022 Background The role of the Endocannabinoids (ECs) in insulin resistance, and their association with visceral obesity and metabolic profile have been studied extensively.
Hadi Bazyar +7 more
doaj +1 more source