Results 61 to 70 of about 54,731 (237)

Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex [PDF]

, 2018
Background Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone “set the
Baker, David A., Cravatt, Benjamin F., Doncheck, Elizabeth M., Graf, Evan N., Hillard, Cecilia J., Li, Yan, Liu, Qing-Song, Mantsch, John R., McReynolds, Jayme R., Ogasawara, Daisuke, Vranjkovic, Oliver   +10 more
core   +1 more source

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua, Gardner, Eliot L, He, Yi, Jordan, Chloe J, Li, Jie, Li, Xia, Peng, Xiao-Qing, Xi, Zheng-Xiong, Yang, Hong-Ju, Zhang, Hai-Ying   +9 more
core   +2 more sources

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy

Nature Communications, 2018
The regenerative capacity of muscle stem cells is impaired in Duchenne muscular dystrophy (DMD). Here, the authors show that the endocannabinoid receptor CB1 is activated by PAX7 in muscle stem cells, and that pharmacological inhibition of CB1 promotes ...
Fabio A. Iannotti, Ester Pagano, Ombretta Guardiola, Simone Adinolfi, Valentina Saccone, Silvia Consalvi, Fabiana Piscitelli, Elisabetta Gazzerro, Giuseppe Busetto, Diego Carrella, Raffaele Capasso, Pier Lorenzo Puri, Gabriella Minchiotti, Vincenzo Di Marzo   +13 more
doaj   +1 more source

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

Palmitoylethanolamide and Related ALIAmides: Prohomeostatic Lipid Compounds for Animal Health and Wellbeing

Veterinary Sciences, 2020
Virtually every cellular process is affected by diet and this represents the foundation of dietary management to a variety of small animal disorders. Special attention is currently being paid to a family of naturally occurring lipid amides acting through
Enrico Gugliandolo, Alessio Filippo Peritore, Cristian Piras, Salvatore Cuzzocrea, Rosalia Crupi   +4 more
doaj   +1 more source

Metabolic Messengers: endocannabinoids

Nature Metabolism, 2022
We also thank all the members of A.B.-G.’s, J.P.B.’s and G.M.’s labs for useful discussions and for their invaluable support. The work of A.B.-G. is supported by: Agencia Estatal de Investigación-FEDER (RTI2018-093667-A-100); the ERC starting Grant (HighMemory, #948217); the IBRO Return Home Fellowships 2019 and the Ramon y Cajal programme (RYC-2017 ...
Arnau Busquets-García, Juan P. Bolaños, Giovanni Marsicano   +2 more
openaire   +4 more sources

New Synthetic Endocannabinoid as Anti-Inflammaging Cosmetic Active: an In Vitro Study on a Reconstructed Skin Model [PDF]

, 2019
Endocannabinoids have been recently appointed as interesting cosmetic actives in regulating inflammaging, a state of chronic low-grade inflammation, known for being involved in many senescence\u2019s manifestations, included skin aging.
Caviola, E, Galizia, G and Baratto G, Meloni, M, Semenzato, A   +3 more
core  

Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit [PDF]

, 2016
Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction.
Caioli, Silvia, De Bartolo, Paola, LARICCHIUTA, DANIELA, PETROSINI, Laura, Saba, Luana, Zona, Cristina   +5 more
core   +1 more source

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

Andrology, EarlyView.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik, Jessica M. Snyder, Haley A. Martin, John K. Amory   +3 more
wiley   +1 more source